Tiziana Bonaldi Department of Experimental Oncology European Institute of Oncology IRCCS (IEO) Biography Publications Institution JoVE Articles Tiziana Bonaldi has not added a biography. If you are Tiziana Bonaldi and would like to personalize this page please email our Author Liaison for assistance. Publications Pharmacological Inhibition of LSD1 Triggers Myeloid Differentiation by Targeting GSE1 Oncogenic Functions in AML Oncogene. 02, 2022 | Pubmed ID: 34862459 Native Chromatin Proteomics (N-ChroP) to Characterize Histone Post-translational Modification (PTM) Combinatorics at Distinct Genomic Regions Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 34382194 Spatial Epi-proteomics Enabled by Histone Post-translational Modification Analysis from Low-abundance Clinical Samples Clinical Epigenetics. 07, 2021 | Pubmed ID: 34315505 Software Options for the Analysis of MS-Proteomic Data Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 34236654 Microbiota Derived Short Chain Fatty Acids Promote Histone Crotonylation in the Colon Through Histone Deacetylases Nature Communications. 01, 2018 | Pubmed ID: 29317660 Quantitative Chemical Proteomics Identifies Novel Targets of the Anti-cancer Multi-kinase Inhibitor E-3810 Molecular & Cellular Proteomics : MCP. Apr, 2014 | Pubmed ID: 24696502 Biochemical Systems Approaches for the Analysis of Histone Modification Readout Biochimica Et Biophysica Acta. Mar, 2014 | Pubmed ID: 24681439 Polycomb-dependent H3K27me1 and H3K27me2 Regulate Active Transcription and Enhancer Fidelity Molecular Cell. Jan, 2014 | Pubmed ID: 24289921 Threshold-controlled Ubiquitination of the EGFR Directs Receptor Fate The EMBO Journal. Jul, 2013 | Pubmed ID: 23799367 Mass Spectrometry-based Identification and Characterisation of Lysine and Arginine Methylation in the Human Proteome Molecular BioSystems. Sep, 2013 | Pubmed ID: 23748837 Cell Reprogramming Requires Silencing of a Core Subset of Polycomb Targets PLoS Genetics. 2013 | Pubmed ID: 23468641 Mass Spectrometry-based Proteomics for the Analysis of Chromatin Structure and Dynamics International Journal of Molecular Sciences. 2013 | Pubmed ID: 23466885 Reply to "Chaetocin is a Nonspecific Inhibitor of Histone Lysine Methyltransferases" Nature Chemical Biology. Mar, 2013 | Pubmed ID: 23416388 Tet Proteins Connect the O-linked N-acetylglucosamine Transferase Ogt to Chromatin in Embryonic Stem Cells Molecular Cell. Feb, 2013 | Pubmed ID: 23352454 The Proteomic Investigation of Chromatin Functional Domains Reveals Novel Synergisms Among Distinct Heterochromatin Components Molecular & Cellular Proteomics : MCP. Mar, 2013 | Pubmed ID: 23319141 Methylation of CenH3 Arginine 37 Regulates Kinetochore Integrity and Chromosome Segregation Proceedings of the National Academy of Sciences of the United States of America. Jun, 2012 | Pubmed ID: 22615363 Yin Yang 1 Extends the Myc-related Transcription Factors Network in Embryonic Stem Cells Nucleic Acids Research. Apr, 2012 | Pubmed ID: 22210892 Substantial Histone Reduction Modulates Genomewide Nucleosomal Occupancy and Global Transcriptional Output PLoS Biology. Jun, 2011 | Pubmed ID: 21738444 SILAC-based Proteomic Analysis to Dissect the "histone Modification Signature" of Human Breast Cancer Cells Amino Acids. Jul, 2011 | Pubmed ID: 20617350 Systems Biology "on-the-fly": SILAC-based Quantitative Proteomics and RNAi Approach in Drosophila Melanogaster Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20824466 Il Complesso HP1alpha-CAF1-SetDB1-contenente Fornisce H3K9me1 Per K9me3 Suv39-mediata in Pericentrica Eterocromatina EMBO Reports. Jul, 2009 | Pubmed ID: 19498464 Systems-wide Analysis of a Phosphatase Knock-down by Quantitative Proteomics and Phosphoproteomics Molecular & Cellular Proteomics : MCP. Aug, 2009 | Pubmed ID: 19429919 Combined Use of RNAi and Quantitative Proteomics to Study Gene Function in Drosophila Molecular Cell. Sep, 2008 | Pubmed ID: 18775334 Quantitative Proteomics As a New Piece of the Systems Biology Puzzle Journal of Proteomics. Aug, 2008 | Pubmed ID: 18640294 Iodoacetamide-induced Artifact Mimics Ubiquitination in Mass Spectrometry Nature Methods. Jun, 2008 | Pubmed ID: 18511913 Site-specific Acetylation of ISWI by GCN5 BMC Molecular Biology. 2007 | Pubmed ID: 17760996 PTMs on H3 Variants Before Chromatin Assembly Potentiate Their Final Epigenetic State Molecular Cell. Oct, 2006 | Pubmed ID: 17052464 "Chromatomics" the Analysis of the Chromatome Molecular BioSystems. Jul, 2005 | Pubmed ID: 16880972 Identification of a Specific Inhibitor of the Histone Methyltransferase SU(VAR)3-9 Nature Chemical Biology. Aug, 2005 | Pubmed ID: 16408017 Loss of Acetylation at Lys16 and Trimethylation at Lys20 of Histone H4 is a Common Hallmark of Human Cancer Nature Genetics. Apr, 2005 | Pubmed ID: 15765097 The Long Acidic Tail of High Mobility Group Box 1 (HMGB1) Protein Forms an Extended and Flexible Structure That Interacts with Specific Residues Within and Between the HMG Boxes Biochemistry. Sep, 2004 | Pubmed ID: 15379539 A Combination of Different Mass Spectroscopic Techniques for the Analysis of Dynamic Changes of Histone Modifications Proteomics. May, 2004 | Pubmed ID: 15188406 The N-terminus of Drosophila SU(VAR)3-9 Mediates Dimerization and Regulates Its Methyltransferase Activity Biochemistry. Mar, 2004 | Pubmed ID: 15035645 The Use of Mass Spectrometry for the Analysis of Histone Modifications Methods in Enzymology. 2004 | Pubmed ID: 14979021 Monocytic Cells Hyperacetylate Chromatin Protein HMGB1 to Redirect It Towards Secretion The EMBO Journal. Oct, 2003 | Pubmed ID: 14532127 The DNA Chaperone HMGB1 Facilitates ACF/CHRAC-dependent Nucleosome Sliding The EMBO Journal. Dec, 2002 | Pubmed ID: 12486007 Clinical Application of Mass Spectrometry-Based Proteomics in Lung Cancer Early Diagnosis Proteomics. Clinical Applications. | Pubmed ID: 32418314 Biochemical and Computational Approaches for the Large-Scale Analysis of Protein Arginine Methylation by Mass Spectrometry Current Protein & Peptide Science. | Pubmed ID: 32338214 Targeting the Scaffolding Role of LSD1 (KDM1A) Poises Acute Myeloid Leukemia Cells for Retinoic Acid-induced Differentiation Science Advances. | Pubmed ID: 32284990 PRMT1 Is Recruited Via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin Cell Reports. | Pubmed ID: 31995759 PRMT1-mediated Methylation of the Microprocessor-associated Proteins Regulates MicroRNA Biogenesis Nucleic Acids Research. | Pubmed ID: 31777917 Enrichment of Histones from Patient Samples for Mass Spectrometry-based Analysis of Post-translational Modifications Methods (San Diego, Calif.). | Pubmed ID: 31605746 Epigenetic Drug Target Deconvolution by Mass Spectrometry-based Technologies Nature Structural & Molecular Biology. | Pubmed ID: 31582842 HSWATH: Unlocking SWATH's Full Potential for an Untargeted Histone Perspective Journal of Proteome Research. | Pubmed ID: 31429292 Therapeutic Targeting of RNA Splicing Catalysis Through Inhibition of Protein Arginine Methylation Cancer Cell. | Pubmed ID: 31408619 Profiling of Epigenetic Features in Clinical Samples Reveals Novel Widespread Changes in Cancer Cancers. | Pubmed ID: 31137727 Proteomics Profiling of Arginine Methylation Defines PRMT5 Substrate Specificity Science Signaling. | Pubmed ID: 30940768 HmSEEKER: Identification of HmSILAC Doublets in MaxQuant Output Data Proteomics. | Pubmed ID: 30656827 Alternative Digestion Approaches Improve Histone Modification Mapping by Mass Spectrometry in Clinical Samples Proteomics. Clinical Applications. | Pubmed ID: 30471193 Mass Spectrometry-Based Proteomics to Unveil the Non-coding RNA World Frontiers in Molecular Biosciences. | Pubmed ID: 30467545 The Kinetochore Module Okp1/Ame1 is a Reader for N-terminal Modifications on the Centromeric Histone Cse4 The EMBO Journal. | Pubmed ID: 30389668 Extensive and Systematic Rewiring of Histone Post-translational Modifications in Cancer Model Systems Nucleic Acids Research. | Pubmed ID: 29618087 Zc3h10 is a Novel Mitochondrial Regulator EMBO Reports. | Pubmed ID: 29507079 PARP14 Controls the Nuclear Accumulation of a Subset of Type I IFN-Inducible Proteins Journal of Immunology (Baltimore, Md. : 1950). | Pubmed ID: 29500242 A Role for CENP-A/Cse4 Phosphorylation on Serine 33 in Deposition at the Centromere FEMS Yeast Research. | Pubmed ID: 29272409 Chromatin Proteomics Reveals Novel Combinatorial Histone Modification Signatures That Mark Distinct Subpopulations of Macrophage Enhancers Nucleic Acids Research. | Pubmed ID: 28981749 Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models ACS Medicinal Chemistry Letters. | Pubmed ID: 28835804 PAT-H-MS Coupled with Laser Microdissection to Study Histone Post-translational Modifications in Selected Cell Populations from Pathology Samples Clinical Epigenetics. | Pubmed ID: 28702092 High Constitutive Activity of a Broad Panel of Housekeeping and Tissue-specific -regulatory Elements Depends on a Subset of ETS Proteins Genes & Development. | Pubmed ID: 28275002 SILAC-Based Quantitative Strategies for Accurate Histone Posttranslational Modification Profiling Across Multiple Biological Samples Methods in Molecular Biology (Clifton, N.J.). | Pubmed ID: 27854018 Mass-spectrometry Analysis of Histone Post-translational Modifications in Pathology Tissue Using the PAT-H-MS Approach Data in Brief. | Pubmed ID: 27408908 Quantitative Assessment of Chemical Artefacts Produced by Propionylation of Histones Prior to Mass Spectrometry Analysis Proteomics. | Pubmed ID: 27373704 Spatiotemporal Plasticity of MiRNAs Functions: The MiR-17-92 Case Molecular & Cellular Oncology. | Pubmed ID: 27314099 The EGFR-specific Antibody Cetuximab Combined with Chemotherapy Triggers Immunogenic Cell Death Nature Medicine. | Pubmed ID: 27135741 MYC/miR-17-92 Interplay Maintains B-lymphoma Cell Homeostasis Cell Cycle (Georgetown, Tex.). | Pubmed ID: 27097369 MS-analysis of SILAC-labeled MYC-driven B Lymphoma Cells Overexpressing MiR-17-19b Data in Brief. | Pubmed ID: 26977435 Recent Advances in Mass Spectrometry Analysis of Histone Post-translational Modifications: Potential Clinical Impact of the PAT-H-MS Approach Expert Review of Proteomics. | Pubmed ID: 26822344 The Contribution of Mass Spectrometry-based Proteomics to Understanding Epigenetics Epigenomics. | Pubmed ID: 26606673 MiR-17-92 Fine-tunes MYC Expression and Function to Ensure Optimal B Cell Lymphoma Growth Nature Communications. | Pubmed ID: 26555894 Pathology Tissue-quantitative Mass Spectrometry Analysis to Profile Histone Post-translational Modification Patterns in Patient Samples Molecular & Cellular Proteomics : MCP. | Pubmed ID: 26463340 Extracellular Vesicle-mediated Transfer of CLIC1 Protein is a Novel Mechanism for the Regulation of Glioblastoma Growth Oncotarget. | Pubmed ID: 26429879 ARGONAUTE2 Cooperates with SWI/SNF Complex to Determine Nucleosome Occupancy at Human Transcription Start Sites Nucleic Acids Research. | Pubmed ID: 25605800 Improved Bottom-up Strategy to Efficiently Separate Hypermodified Histone Peptides Through Ultra-HPLC Separation on a Bench Top Orbitrap Instrument Proteomics. | Pubmed ID: 25073962 Proteomics Meets Genetics: SILAC Labeling of Drosophila Melanogaster Larvae and Cells for in Vivo Functional Studies Methods in Molecular Biology (Clifton, N.J.). | Pubmed ID: 25059620 Un approccio proteomico basato sulla spettrometria di massa per l'analisi globale e ad alta confidenza della R-metilazione delle proteine Marianna Maniaci*1,2, Federica Marini*1, Enrico Massignani1,2, Tiziana Bonaldi1 1Department of Experimental Oncology, European Institute of Oncology IRCCS (IEO), 2European School of Molecular Medicine (SEMM), c/o Campus IFOM-IEO JoVE 62409 Biochemistry L'approccio ChroP Combina ChIP e Spettrometria di Massa a sezionare Locus-specifiche proteomica Paesaggi della cromatina Monica Soldi1, Tiziana Bonaldi1 1Department of Experimental Oncology, European Institute of Oncology JoVE 51220 Biology
Un approccio proteomico basato sulla spettrometria di massa per l'analisi globale e ad alta confidenza della R-metilazione delle proteine Marianna Maniaci*1,2, Federica Marini*1, Enrico Massignani1,2, Tiziana Bonaldi1 1Department of Experimental Oncology, European Institute of Oncology IRCCS (IEO), 2European School of Molecular Medicine (SEMM), c/o Campus IFOM-IEO JoVE 62409 Biochemistry
L'approccio ChroP Combina ChIP e Spettrometria di Massa a sezionare Locus-specifiche proteomica Paesaggi della cromatina Monica Soldi1, Tiziana Bonaldi1 1Department of Experimental Oncology, European Institute of Oncology JoVE 51220 Biology