Tommy Alain Goodman Cancer Centre and Department of Biochemistry McGill University Biography Publications Institution JoVE Articles Tommy Alain has not added a biography. If you are Tommy Alain and would like to personalize this page please email our Author Liaison for assistance. Publications Multifaceted Regulation of Somatic Cell Reprogramming by MRNA Translational Control Cell Stem Cell. May, 2014 | Pubmed ID: 24630793 Control of Paip1-eukayrotic Translation Initiation Factor 3 Interaction by Amino Acids Through S6 Kinase Molecular and Cellular Biology. Mar, 2014 | Pubmed ID: 24396066 MTORC1 Controls Mitochondrial Activity and Biogenesis Through 4E-BP-dependent Translational Regulation Cell Metabolism. Nov, 2013 | Pubmed ID: 24206664 Translational Control of Entrainment and Synchrony of the Suprachiasmatic Circadian Clock by MTOR/4E-BP1 Signaling Neuron. Aug, 2013 | Pubmed ID: 23972597 Control of Translation and MiRNA-dependent Repression by a Novel Poly(A) Binding Protein, HnRNP-Q PLoS Biology. 2013 | Pubmed ID: 23700384 Degradation of Newly Synthesized Polypeptides by Ribosome-associated RACK1/c-Jun N-terminal Kinase/eukaryotic Elongation Factor 1A2 Complex Molecular and Cellular Biology. Jul, 2013 | Pubmed ID: 23608534 MTOR Inhibitor Efficacy is Determined by the EIF4E/4E-BP Ratio Oncotarget. Dec, 2012 | Pubmed ID: 23455427 EIF4E/4E-BP Ratio Predicts the Efficacy of MTOR Targeted Therapies Cancer Research. Dec, 2012 | Pubmed ID: 23100465 A Novel 4EHP-GIGYF2 Translational Repressor Complex is Essential for Mammalian Development Molecular and Cellular Biology. Sep, 2012 | Pubmed ID: 22751931 Distinct Perturbation of the Translatome by the Antidiabetic Drug Metformin Proceedings of the National Academy of Sciences of the United States of America. Jun, 2012 | Pubmed ID: 22611195 Translational Control of the Activation of Transcription Factor NF-κB and Production of Type I Interferon by Phosphorylation of the Translation Factor EIF4E Nature Immunology. Jun, 2012 | Pubmed ID: 22544393 Structure-activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic PH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling The Journal of Biological Chemistry. May, 2012 | Pubmed ID: 22474287 IL-15 Can Signal Via IL-15Rα, JNK, and NF-κB to Drive RANTES Production by Myeloid Cells Journal of Immunology (Baltimore, Md. : 1950). May, 2012 | Pubmed ID: 22447977 Virus-tumor Interactome Screen Reveals ER Stress Response Can Reprogram Resistant Cancers for Oncolytic Virus-triggered Caspase-2 Cell Death Cancer Cell. Oct, 2011 | Pubmed ID: 22014571 Pharmacological and Genetic Evaluation of Proposed Roles of Mitogen-activated Protein Kinase/extracellular Signal-regulated Kinase Kinase (MEK), Extracellular Signal-regulated Kinase (ERK), and P90(RSK) in the Control of MTORC1 Protein Signaling by Phorbol Esters The Journal of Biological Chemistry. Aug, 2011 | Pubmed ID: 21659537 MTORC1-mediated Cell Proliferation, but Not Cell Growth, Controlled by the 4E-BPs Science (New York, N.Y.). May, 2010 | Pubmed ID: 20508131 Synergistic Effects Between Analogs of DNA and RNA Improve the Potency of SiRNA-mediated Gene Silencing Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20413581 Vesicular Stomatitis Virus Oncolysis is Potentiated by Impairing MTORC1-dependent Type I IFN Production Proceedings of the National Academy of Sciences of the United States of America. Jan, 2010 | Pubmed ID: 20080710 Myxoma Virus Virotherapy for Glioma in Immunocompetent Animal Models: Optimizing Administration Routes and Synergy with Rapamycin Cancer Research. Jan, 2010 | Pubmed ID: 20068158 Susceptibility of Mantle Cell Lymphomas to Reovirus Oncolysis Leukemia Research. Jan, 2010 | Pubmed ID: 19651440 The Helicase Protein DHX29 Promotes Translation Initiation, Cell Proliferation, and Tumorigenesis Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 20018725 P53-dependent Translational Control of Senescence and Transformation Via 4E-BPs Cancer Cell. Nov, 2009 | Pubmed ID: 19878875 Transcription Factors Down-stream of Ras As Molecular Indicators for Targeting Malignancies with Oncolytic Herpes Virus Molecular Oncology. Dec, 2009 | Pubmed ID: 19766068 Targeting Human Medulloblastoma: Oncolytic Virotherapy with Myxoma Virus is Enhanced by Rapamycin Cancer Research. Sep, 2007 | Pubmed ID: 17875723 Proteolytic Disassembly is a Critical Determinant for Reovirus Oncolysis Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2007 | Pubmed ID: 17519890 Effects of Intravenously Administered Recombinant Vesicular Stomatitis Virus (VSV(deltaM51)) on Multifocal and Invasive Gliomas Journal of the National Cancer Institute. Nov, 2006 | Pubmed ID: 17077357 Myxoma Virus is a Novel Oncolytic Virus with Significant Antitumor Activity Against Experimental Human Gliomas Cancer Research. Nov, 2005 | Pubmed ID: 16267023 Stromelysin-2 (matrix Metalloproteinase 10) is Inducible in Lymphoma Cells and Accelerates the Growth of Lymphoid Tumors in Vivo Journal of Immunology (Baltimore, Md. : 1950). Sep, 2004 | Pubmed ID: 15356104 Lymphomas and Oncolytic Virus Therapy Clinical Lymphoma. Sep, 2003 | Pubmed ID: 14556682 Reovirus Therapy of Lymphoid Malignancies Blood. Dec, 2002 | Pubmed ID: 12393565 Oncolytic Reovirus Against Ovarian and Colon Cancer Cancer Research. Mar, 2002 | Pubmed ID: 11912142 Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale Valentina Gandin1, Kristina Sikström2, Tommy Alain3, Masahiro Morita3, Shannon McLaughlan1, Ola Larsson2, Ivan Topisirovic1 1Lady Davis Institute and Department of Oncology, McGill University, 2Department of Oncology-Pathology, Karolinska Institutet, 3Goodman Cancer Centre and Department of Biochemistry, McGill University JoVE 51455 Biology
Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale Valentina Gandin1, Kristina Sikström2, Tommy Alain3, Masahiro Morita3, Shannon McLaughlan1, Ola Larsson2, Ivan Topisirovic1 1Lady Davis Institute and Department of Oncology, McGill University, 2Department of Oncology-Pathology, Karolinska Institutet, 3Goodman Cancer Centre and Department of Biochemistry, McGill University JoVE 51455 Biology