Tomohiro Miyasaka Department of Neuropathology, Faculty of Life and Medical Sciences Doshisha University Biography Publications Institution JoVE Articles Tomohiro Miyasaka has not added a biography. If you are Tomohiro Miyasaka and would like to personalize this page please email our Author Liaison for assistance. Publications Mass Spectrometry Imaging in Alzheimer's Disease Brain Connectivity. Aug, 2023 | Pubmed ID: 36905365 The Senile Plaque: Morphological Differences in APP Knock-in Mice Brains by Fixatives Brain and Behavior. Apr, 2023 | Pubmed ID: 36879381 Identification of Tau Protein As a Novel Marker for Maturation and Pathological Changes of Oligodendrocytes Glia. Apr, 2023 | Pubmed ID: 36565228 The Organization of Microtubules and Tau in Oligodendrocytes: Tau Pathology in Damaged Oligodendrocytes Frontiers in Cell and Developmental Biology. 2022 | Pubmed ID: 36274848 Quantum-dot-labeled Synuclein Seed Assay Identifies Drugs Modulating the Experimental Prion-like Transmission Communications Biology. Jun, 2022 | Pubmed ID: 35768587 Microtubule Assembly by Tau Impairs Endocytosis and Neurotransmission Via Dynamin Sequestration in Alzheimer's Disease Synapse Model ELife. Apr, 2022 | Pubmed ID: 35471147 Therapeutic Effect of a Novel Curcumin Derivative GT863 on a Mouse Model of Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. Nov, 2022 | Pubmed ID: 34894926 Disulfide Bond Formation in Microtubule-associated Tau Protein Promotes Tau Accumulation and Toxicity in Vivo Human Molecular Genetics. Oct, 2021 | Pubmed ID: 34137825 Quantitative Fractionation of Tissue Microtubules with Distinct Biochemical Properties Reflecting Their Stability and Lability Biochemical and Biophysical Research Communications. Jun, 2021 | Pubmed ID: 33992960 A Potential Defense Mechanism Against Amyloid Deposition in Cerebellum Biochemical and Biophysical Research Communications. Jan, 2021 | Pubmed ID: 33340762 The Inducible Amphisome Isolates Viral Hemagglutinin and Defends Against Influenza A Virus Infection Nature Communications. Jan, 2020 | Pubmed ID: 31919357 Inhibition of Microtubule Assembly Competent Tubulin Synthesis Leads to Accumulation of Phosphorylated Tau in Neuronal Cell Bodies Biochemical and Biophysical Research Communications. Jan, 2020 | Pubmed ID: 31699369 Regulatory Mechanisms for the Axonal Localization of Tau Protein in Neurons Molecular Biology of the Cell. Sep, 2019 | Pubmed ID: 31364926 Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2019 | Pubmed ID: 31235644 Distribution of Endogenous Normal Tau in the Mouse Brain The Journal of Comparative Neurology. Apr, 2019 | Pubmed ID: 30408165 Distribution of Oxidized DJ-1 in Parkinson's Disease-related Sites in the Brain and in the Peripheral Tissues: Effects of Aging and a Neurotoxin Scientific Reports. Aug, 2018 | Pubmed ID: 30104666 Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in Models of Tauopathy Frontiers in Neuroscience. 2018 | Pubmed ID: 29973863 Isoform-independent and -dependent Phosphorylation of Microtubule-associated Protein Tau in Mouse Brain During Postnatal Development The Journal of Biological Chemistry. 02, 2018 | Pubmed ID: 29196605 Distinct Deposition of Amyloid-β Species in Brains with Alzheimer's Disease Pathology Visualized with MALDI Imaging Mass Spectrometry Acta Neuropathologica Communications. 10, 2017 | Pubmed ID: 29037261 The Role of the Carboxyl-Terminal Sequence of Tau and MAP2 in the Pathogenesis of Dementia Frontiers in Molecular Neuroscience. 2016 | Pubmed ID: 28082867 Curcumin Improves Tau-induced Neuronal Dysfunction of Nematodes Neurobiology of Aging. Mar, 2016 | Pubmed ID: 26923403 Toxic Tau Oligomer Formation Blocked by Capping of Cysteine Residues with 1,2-dihydroxybenzene Groups Nature Communications. Dec, 2015 | Pubmed ID: 26671725 Identification of Key Amino Acids Responsible for the Distinct Aggregation Properties of Microtubule-associated Protein 2 and Tau Journal of Neurochemistry. Oct, 2015 | Pubmed ID: 26134402 Immunostaining of Oxidized DJ-1 in Human and Mouse Brains Journal of Neuropathology and Experimental Neurology. Jul, 2014 | Pubmed ID: 24918637 The Homologous Carboxyl-terminal Domains of Microtubule-associated Protein 2 and TAU Induce Neuronal Dysfunction and Have Differential Fates in the Evolution of Neurofibrillary Tangles PloS One. 2014 | Pubmed ID: 24587039 Substrate Ectodomain is Critical for Substrate Preference and Inhibition of γ-secretase Nature Communications. 2013 | Pubmed ID: 24108142 Central Nervous System-specific Deletion of Transcription Factor Nrf1 Causes Progressive Motor Neuronal Dysfunction Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Jun, 2011 | Pubmed ID: 21554501 Microtubule Destruction Induces Tau Liberation and Its Subsequent Phosphorylation FEBS Letters. Jul, 2010 | Pubmed ID: 20561519 Anesthesia-induced Hyperphosphorylation Detaches 3-repeat Tau from Microtubules Without Affecting Their Stability in Vivo The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2008 | Pubmed ID: 19036972 Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived IPSCs Stem Cell Reports. | Pubmed ID: 31543469 Kwantitatieve fractioneringstechniek voor microtubuli om stabiele microtubuli, labiele microtubuli en vrije tubuline in muizenweefsels te scheiden Ayaka Hagita-Tatsumoto1,2, Tomohiro Miyasaka1,2,3 1Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, 2Center for Research in Neurodegenerative Diseases, Doshisha University, 3Laboratory of Physiology and Anatomy, School of Pharmacy, Nihon University JoVE 63358 Biochemistry Visualisatie van amyloïde β-deposito's in de menselijke hersenen met Laser Matrix-bijgewoonde desorptie/ionisatie massaspectrometrie Imaging Masaya Ikegawa*1, Takashi Nirasawa*2, Nobuto Kakuda1, Tomohiro Miyasaka1, Yuki Kuzuhara1, Shigeo Murayama3, Yasuo Ihara4 1Department of Life and Medical Systems, Doshisha University, 2Bruker Daltonics K.K., 3The Brain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 4Graduate School of Brain Science, Doshisha University JoVE 57645 Neuroscience
Kwantitatieve fractioneringstechniek voor microtubuli om stabiele microtubuli, labiele microtubuli en vrije tubuline in muizenweefsels te scheiden Ayaka Hagita-Tatsumoto1,2, Tomohiro Miyasaka1,2,3 1Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, 2Center for Research in Neurodegenerative Diseases, Doshisha University, 3Laboratory of Physiology and Anatomy, School of Pharmacy, Nihon University JoVE 63358 Biochemistry
Visualisatie van amyloïde β-deposito's in de menselijke hersenen met Laser Matrix-bijgewoonde desorptie/ionisatie massaspectrometrie Imaging Masaya Ikegawa*1, Takashi Nirasawa*2, Nobuto Kakuda1, Tomohiro Miyasaka1, Yuki Kuzuhara1, Shigeo Murayama3, Yasuo Ihara4 1Department of Life and Medical Systems, Doshisha University, 2Bruker Daltonics K.K., 3The Brain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 4Graduate School of Brain Science, Doshisha University JoVE 57645 Neuroscience