Ulrik Gether Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen Biography Publications Institution JoVE Articles Ulrik Gether has not added a biography. If you are Ulrik Gether and would like to personalize this page please email our Author Liaison for assistance. Publications Subjective Perception of Cocaine Reward in Mice Assessed by a Single Exposure Place Preference (sePP) Paradigm Journal of Neuroscience Methods. Sep, 2017 | Pubmed ID: 28711378 Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research Basic & Clinical Pharmacology & Toxicology. Jun, 2017 | Pubmed ID: 28609587 Investigating the Molecular Mechanism of Positive and Negative Allosteric Modulators in the Calcium-sensing Receptor Dimer Scientific Reports. Apr, 2017 | Pubmed ID: 28417952 The GPRC6A Receptor Displays Constitutive Internalization and Sorting to the Slow Recycling Pathway The Journal of Biological Chemistry. Apr, 2017 | Pubmed ID: 28280242 Direct Assessment of Substrate Binding to the Neurotransmitter:Sodium Symporter LeuT by Solid State NMR ELife. Jan, 2017 | Pubmed ID: 28117663 Preserved Dopaminergic Homeostasis and Dopamine-related Behaviour in Hemizygous TH-Cre Mice The European Journal of Neuroscience. Jan, 2017 | Pubmed ID: 27453291 The Environment Shapes the Inner Vestibule of LeuT PLoS Computational Biology. Nov, 2016 | Pubmed ID: 27835643 Transition Metal Ion FRET Uncovers K(+) Regulation of a Neurotransmitter/sodium Symporter Nature Communications. Sep, 2016 | Pubmed ID: 27678200 Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290 The Journal of Biological Chemistry. Sep, 2016 | Pubmed ID: 27474737 Structural Biology: Antidepressants at Work Nature. Apr, 2016 | Pubmed ID: 27049942 A Kinome Wide Screen Identifies Novel Kinases Involved in Regulation of Monoamine Transporter Function Neurochemistry International. Sep, 2016 | Pubmed ID: 27020406 Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini The Journal of Biological Chemistry. Mar, 2016 | Pubmed ID: 26786096 Effect of Escitalopram Versus Placebo on GRα Messenger RNA Expression in Peripheral Blood Cells of Healthy Individuals with a Family History of Depression - a Secondary Outcome Analysis from the Randomized AGENDA Trial Nordic Journal of Psychiatry. 2016 | Pubmed ID: 26752119 Structure-activity Relationship Studies of Citalopram Derivatives: Examining Substituents Conferring Selectivity for the Allosteric Site in the 5-HT Transporter British Journal of Pharmacology. Mar, 2016 | Pubmed ID: 26699847 No Effect of Escitalopram Versus Placebo on Brain-derived Neurotrophic Factor in Healthy Individuals: a Randomised Trial Acta Neuropsychiatrica. Apr, 2016 | Pubmed ID: 26573431 Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:sodium Symporter The Journal of Biological Chemistry. Oct, 2015 | Pubmed ID: 26363074 [Optogenetics Brings Hidden Neural Mechanisms into the Light and Could Become a Future Therapy] Ugeskrift for Laeger. Aug, 2015 | Pubmed ID: 26320592 A Novel Dopamine Transporter Transgenic Mouse Line for Identification and Purification of Midbrain Dopaminergic Neurons Reveals Midbrain Heterogeneity The European Journal of Neuroscience. Oct, 2015 | Pubmed ID: 26286107 Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering Structure (London, England : 1993). Jul, 2015 | Pubmed ID: 26073603 Amphetamine Action at the Cocaine- and Antidepressant-sensitive Serotonin Transporter is Modulated by αCaMKII The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2015 | Pubmed ID: 26019340 Mechanism of the Association Between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters The Journal of Biological Chemistry. May, 2015 | Pubmed ID: 25869126 Rare Autism-associated Variants Implicate Syntaxin 1 (STX1 R26Q) Phosphorylation and the Dopamine Transporter (hDAT R51W) in Dopamine Neurotransmission and Behaviors EBioMedicine. Feb, 2015 | Pubmed ID: 25774383 Akt-mediated Regulation of Antidepressant-sensitive Serotonin Transporter Function, Cell-surface Expression and Phosphorylation The Biochemical Journal. May, 2015 | Pubmed ID: 25761794 The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2014 | Pubmed ID: 25100601 The Second Sodium Site in the Dopamine Transporter Controls Cation Permeation and is Regulated by Chloride The Journal of Biological Chemistry. Sep, 2014 | Pubmed ID: 25063810 Protein Interacting with C-kinase 1 (PICK1) Binding Promiscuity Relies on Unconventional PSD-95/discs-large/ZO-1 Homology (PDZ) Binding Modes for Nonclass II PDZ Ligands The Journal of Biological Chemistry. Sep, 2014 | Pubmed ID: 25023278 The Serotonin Transporter Undergoes Constitutive Internalization and is Primarily Sorted to Late Endosomes and Lysosomal Degradation The Journal of Biological Chemistry. Aug, 2014 | Pubmed ID: 24973209 Novel and High Affinity Fluorescent Ligands for the Serotonin Transporter Based on (s)-citalopram ACS Medicinal Chemistry Letters. Jun, 2014 | Pubmed ID: 24944746 Missense Dopamine Transporter Mutations Associate with Adult Parkinsonism and ADHD The Journal of Clinical Investigation. Jul, 2014 | Pubmed ID: 24911152 In Vivo Amphetamine Action is Contingent on αCaMKII Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Oct, 2014 | Pubmed ID: 24871545 Reply to Wilkinson Et Al.: Concerning the Use of PHluorin-tagged GluA2 As a Reporter for NMDA-induced AMPA Receptor Recycling Proceedings of the National Academy of Sciences of the United States of America. Jan, 2014 | Pubmed ID: 24596955 Serotonin-induced Down-regulation of Cell Surface Serotonin Transporter Neurochemistry International. Jul, 2014 | Pubmed ID: 24462583 Novel Tripod Amphiphiles for Membrane Protein Analysis Chemistry (Weinheim an Der Bergstrasse, Germany). Nov, 2013 | Pubmed ID: 24123610 AMPA Receptor PHluorin-GluA2 Reports NMDA Receptor-induced Intracellular Acidification in Hippocampal Neurons Proceedings of the National Academy of Sciences of the United States of America. Aug, 2013 | Pubmed ID: 23940334 Membrane-permeable C-terminal Dopamine Transporter Peptides Attenuate Amphetamine-evoked Dopamine Release The Journal of Biological Chemistry. Sep, 2013 | Pubmed ID: 23884410 Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort PloS One. 2013 | Pubmed ID: 23823136 PICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose Tolerance PLoS Biology. 2013 | Pubmed ID: 23630454 A C-terminal PDZ Domain-binding Sequence is Required for Striatal Distribution of the Dopamine Transporter Nature Communications. 2013 | Pubmed ID: 23481388 Glucose-Neopentyl Glycol (GNG) Amphiphiles for Membrane Protein Study Chemical Communications (Cambridge, England). Feb, 2013 | Pubmed ID: 23165475 Association of the Leucine-7 to Proline-7 Variation in the Signal Sequence of Neuropeptide Y with Major Depression Acta Neuropsychiatrica. Apr, 2012 | Pubmed ID: 26952950 Steric Hindrance Mutagenesis in the Conserved Extracellular Vestibule Impedes Allosteric Binding of Antidepressants to the Serotonin Transporter The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 23007398 A Virtual High-throughput Screening Approach to the Discovery of Novel Inhibitors of the Bacterial Leucine Transporter, LeuT Molecular Membrane Biology. Aug, 2012 | Pubmed ID: 22908980 A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins Chemistry (Weinheim an Der Bergstrasse, Germany). Jul, 2012 | Pubmed ID: 22730191 The Effect of Escitalopram Versus Placebo on Perceived Stress and Salivary Cortisol in Healthy First-degree Relatives of Patients with Depression-A Randomised Trial Psychiatry Research. Dec, 2012 | Pubmed ID: 22703642 The Solute Carrier 6 Family of Transporters British Journal of Pharmacology. Sep, 2012 | Pubmed ID: 22519513 Effect of Chronic Escitalopram Versus Placebo on Personality Traits in Healthy First-degree Relatives of Patients with Depression: a Randomized Trial PloS One. 2012 | Pubmed ID: 22393376 Protein Interacting with C Kinase 1 (PICK1) Reduces Reinsertion Rates of Interaction Partners Sorted to Rab11-dependent Slow Recycling Pathway The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22303009 Serine 77 in the PDZ Domain of PICK1 is a Protein Kinase Cα Phosphorylation Site Regulated by Lipid Membrane Binding Biochemistry. Jan, 2012 | Pubmed ID: 22129425 A Randomized Trial of the Effect of Escitalopram Versus Placebo on Cognitive Function in Healthy First-degree Relatives of Patients with Depression Therapeutic Advances in Psychopharmacology. Oct, 2011 | Pubmed ID: 23983938 Brain-derived Neurotrophic Factor (BDNF) Enhances GABA Transport by Modulating the Trafficking of GABA Transporter-1 (GAT-1) from the Plasma Membrane of Rat Cortical Astrocytes The Journal of Biological Chemistry. Nov, 2011 | Pubmed ID: 21969376 Differences Between Early and Late Onset Adult Depression Clinical Practice and Epidemiology in Mental Health : CP & EMH. 2011 | Pubmed ID: 21866230 SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation Pharmacological Reviews. Sep, 2011 | Pubmed ID: 21752877 Escitalopram and Neuroendocrine Response in Healthy First-degree Relatives to Depressed Patients--a Randomized Placebo-controlled Trial PloS One. 2011 | Pubmed ID: 21738622 A Fluorescence Polarization Based Screening Assay for Identification of Small Molecule Inhibitors of the PICK1 PDZ Domain Combinatorial Chemistry & High Throughput Screening. Aug, 2011 | Pubmed ID: 21534917 Copy Number Variations in Affective Disorders and Meta-analysis Psychiatric Genetics. Dec, 2011 | Pubmed ID: 21451435 The Binding Sites for Benztropines and Dopamine in the Dopamine Transporter Overlap Neuropharmacology. Jan, 2011 | Pubmed ID: 20816875 Tandem Facial Amphiphiles for Membrane Protein Stabilization Journal of the American Chemical Society. Dec, 2010 | Pubmed ID: 21049926 Maltose-neopentyl Glycol (MNG) Amphiphiles for Solubilization, Stabilization and Crystallization of Membrane Proteins Nature Methods. Dec, 2010 | Pubmed ID: 21037590 Structure-activity Relationships of a Small-molecule Inhibitor of the PDZ Domain of PICK1 Organic & Biomolecular Chemistry. Oct, 2010 | Pubmed ID: 20668766 Clinical Utility of Standardised Assessment of Personality - Abbreviated Scale (SAPAS) Among Patients with First Episode Depression Journal of Affective Disorders. Dec, 2010 | Pubmed ID: 20579743 Postendocytic Sorting of Constitutively Internalized Dopamine Transporter in Cell Lines and Dopaminergic Neurons The Journal of Biological Chemistry. Aug, 2010 | Pubmed ID: 20551317 David Versus Goliath Nanomedicine : Nanotechnology, Biology, and Medicine. Aug, 2010 | Pubmed ID: 20417315 The Influence of Comorbid Personality Disorder and Neuroticism on Treatment Outcome in First Episode Depression Psychopathology. 2010 | Pubmed ID: 20375542 Gender Differences Among Patients with a Single Depressive Episode Psychopathology. 2010 | Pubmed ID: 20197709 The N Terminus of Monoamine Transporters is a Lever Required for the Action of Amphetamines The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20118234 Regulation of Dopamine Transporter Function by Protein-protein Interactions: New Discoveries and Methodological Challenges Journal of Neurochemistry. Apr, 2010 | Pubmed ID: 20085610 No Interactions Between Genetic Polymorphisms and Stressful Life Events on Outcome of Antidepressant Treatment European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. May, 2010 | Pubmed ID: 20022223 Identification of a Small-molecule Inhibitor of the PICK1 PDZ Domain That Inhibits Hippocampal LTP and LTD Proceedings of the National Academy of Sciences of the United States of America. Jan, 2010 | Pubmed ID: 20018661 Does Bereavement-related First Episode Depression Differ from Other Kinds of First Depressions? Social Psychiatry and Psychiatric Epidemiology. Aug, 2010 | Pubmed ID: 19693418 Amphipathic Motifs in BAR Domains Are Essential for Membrane Curvature Sensing The EMBO Journal. Nov, 2009 | Pubmed ID: 19816406 PICK1 Expression in the Drosophila Central Nervous System Primarily Occurs in the Neuroendocrine System The Journal of Comparative Neurology. Nov, 2009 | Pubmed ID: 19757495 How Curved Membranes Recruit Amphipathic Helices and Protein Anchoring Motifs Nature Chemical Biology. Nov, 2009 | Pubmed ID: 19749743 Rationale and Design of the Participant, Investigator, Observer, and Data-analyst-blinded Randomized AGENDA Trial on Associations Between Gene-polymorphisms, Endophenotypes for Depression and Antidepressive Intervention: the Effect of Escitalopram Versus Placebo on the Combined Dexamethasone-corticotrophine Releasing Hormone Test and Other Potential Endophenotypes in Healthy First-degree Relatives of Persons with Depression Trials. Aug, 2009 | Pubmed ID: 19671139 A Single Nucleotide Polymorphism in the Human Serotonin Transporter Introduces a New Site for N-linked Glycosylation Neuropharmacology. Sep, 2009 | Pubmed ID: 19500602 Visualization of Dopamine Transporter Trafficking in Live Neurons by Use of Fluorescent Cocaine Analogs The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2009 | Pubmed ID: 19474307 Elucidating Conformational Changes in the Gamma-aminobutyric Acid Transporter-1 The Journal of Biological Chemistry. Jun, 2009 | Pubmed ID: 19363027 Interaction Between Genetic Polymorphisms and Stressful Life Events in First Episode Depression Journal of Affective Disorders. Dec, 2009 | Pubmed ID: 19339052 Validity of the Diagnosis of a Single Depressive Episode in a Case Register Clinical Practice and Epidemiology in Mental Health : CP & EMH. Feb, 2009 | Pubmed ID: 19216741 Do Stressful Life Events Predict Medical Treatment Outcome in First Episode of Depression? Social Psychiatry and Psychiatric Epidemiology. Sep, 2009 | Pubmed ID: 19209372 An Evaluation of the Genetic-matched Pair Study Design Using Genome-wide SNP Data from the European Population European Journal of Human Genetics : EJHG. Jul, 2009 | Pubmed ID: 19156175 Correlation Between Genetic and Geographic Structure in Europe Current Biology : CB. Aug, 2008 | Pubmed ID: 18691889 Syntaxin 1A Interaction with the Dopamine Transporter Promotes Amphetamine-induced Dopamine Efflux Molecular Pharmacology. Oct, 2008 | Pubmed ID: 18617632 The Binding Sites for Cocaine and Dopamine in the Dopamine Transporter Overlap Nature Neuroscience. Jul, 2008 | Pubmed ID: 18568020 Membrane Localization is Critical for Activation of the PICK1 BAR Domain Traffic (Copenhagen, Denmark). Aug, 2008 | Pubmed ID: 18466293 Recruitment of Beta-arrestin2 to the Dopamine D2 Receptor: Insights into Anti-psychotic and Anti-parkinsonian Drug Receptor Signaling Neuropharmacology. Jun, 2008 | Pubmed ID: 18455202 An Intracellular Interaction Network Regulates Conformational Transitions in the Dopamine Transporter The Journal of Biological Chemistry. Jun, 2008 | Pubmed ID: 18426798 Glycine Transporter Dimers: Evidence for Occurrence in the Plasma Membrane The Journal of Biological Chemistry. Apr, 2008 | Pubmed ID: 18252709 Interaction Between the Glutamate Transporter GLT1b and the Synaptic PDZ Domain Protein PICK1 The European Journal of Neuroscience. Jan, 2008 | Pubmed ID: 18184314 Relationship Between Conformational Changes in the Dopamine Transporter and Cocaine-like Subjective Effects of Uptake Inhibitors Molecular Pharmacology. Mar, 2008 | Pubmed ID: 17978168 Membrane Mobility and Microdomain Association of the Dopamine Transporter Studied with Fluorescence Correlation Spectroscopy and Fluorescence Recovery After Photobleaching Biochemistry. Sep, 2007 | Pubmed ID: 17711354 Allosteric Effects of R- and S-citalopram on the Human 5-HT Transporter: Evidence for Distinct High- and Low-affinity Binding Sites European Journal of Pharmacology. Jul, 2007 | Pubmed ID: 17499240 Calmodulin Kinase II Interacts with the Dopamine Transporter C Terminus to Regulate Amphetamine-induced Reverse Transport Neuron. Aug, 2006 | Pubmed ID: 16908408 Neurotransmitter Transporters: Molecular Function of Important Drug Targets Trends in Pharmacological Sciences. Jul, 2006 | Pubmed ID: 16762425 Phosphorylation of the Norepinephrine Transporter at Threonine 258 and Serine 259 is Linked to Protein Kinase C-mediated Transporter Internalization The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16740633 Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine Molecular Pharmacology. Aug, 2006 | Pubmed ID: 16684900 Cooperative Transcription Activation by Nurr1 and Pitx3 Induces Embryonic Stem Cell Maturation to the Midbrain Dopamine Neuron Phenotype Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16477036 Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane Analogues As High-affinity Fluorescent Probes for the Dopamine Transporter Journal of Medicinal Chemistry. Dec, 2005 | Pubmed ID: 16302792 Intramolecular Cross-linking in a Bacterial Homolog of Mammalian SLC6 Neurotransmitter Transporters Suggests an Evolutionary Conserved Role of Transmembrane Segments 7 and 8 Neuropharmacology. Nov, 2005 | Pubmed ID: 16129457 Identification of Intra- and Intermolecular Disulfide Bridges in the Multidrug Resistance Transporter ABCG2 The Journal of Biological Chemistry. Nov, 2005 | Pubmed ID: 16107343 Molecular Determinants for the Complex Binding Specificity of the PDZ Domain in PICK1 The Journal of Biological Chemistry. May, 2005 | Pubmed ID: 15774468 Effect of Walker A Mutation (K86M) on Oligomerization and Surface Targeting of the Multidrug Resistance Transporter ABCG2 Journal of Cell Science. Apr, 2005 | Pubmed ID: 15769853 Purification and Fluorescent Labeling of the Human Serotonin Transporter Biochemistry. Mar, 2005 | Pubmed ID: 15736959 Zinc Potentiates an Uncoupled Anion Conductance Associated with the Dopamine Transporter The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15358780 Surface Targeting of the Dopamine Transporter Involves Discrete Epitopes in the Distal C Terminus but Does Not Require Canonical PDZ Domain Interactions The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2004 | Pubmed ID: 15295038 Identification of Intracellular Residues in the Dopamine Transporter Critical for Regulation of Transporter Conformation and Cocaine Binding The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14597628 Probing Dopamine Transporter Structure and Function by Zn2+-site Engineering European Journal of Pharmacology. Oct, 2003 | Pubmed ID: 14612149 Structural and Functional Probing of the Biogenic Amine Transporters by Fluorescence Spectroscopy European Journal of Pharmacology. Oct, 2003 | Pubmed ID: 14612134 Evidence for Distinct Sodium-, Dopamine-, and Cocaine-dependent Conformational Changes in Transmembrane Segments 7 and 8 of the Dopamine Transporter The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12773538 Residues in the Extracellular Loop 4 Are Critical for Maintaining the Conformational Equilibrium of the Gamma-aminobutyric Acid Transporter-1 The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12764157 N-terminal Truncation of the Dopamine Transporter Abolishes Phorbol Ester- and Substance P Receptor-stimulated Phosphorylation Without Impairing Transporter Internalization The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12464618 Structural Basis for Activation of G-protein-coupled Receptors Pharmacology & Toxicology. Dec, 2002 | Pubmed ID: 12688373 Conformational Basis for the Li(+)-induced Leak Current in the Rat Gamma-aminobutyric Acid (GABA) Transporter-1 The Journal of Physiology. Oct, 2002 | Pubmed ID: 12381817 Passive Water and Urea Permeability of a Human Na(+)-glutamate Cotransporter Expressed in Xenopus Oocytes The Journal of Physiology. Aug, 2002 | Pubmed ID: 12154181 Zn(2+) Site Engineering at the Oligomeric Interface of the Dopamine Transporter FEBS Letters. Jul, 2002 | Pubmed ID: 12135746 The Role of Zinc Ions in Reverse Transport Mediated by Monoamine Transporters The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11940571 Generation of an Activating Zn(2+) Switch in the Dopamine Transporter: Mutation of an Intracellular Tyrosine Constitutively Alters the Conformational Equilibrium of the Transport Cycle Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11818545 Use of Fluorescence Spectroscopy to Study Conformational Changes in the Beta 2-adrenoceptor Methods in Enzymology. 2002 | Pubmed ID: 11665566 Оценка дофаминергической гомеостаза у мышей с использованием высокопроизводительных жидкостной хроматографии анализа и поглощение синаптосомальных допамина Kathrine L. Jensen1, Annika H. Runegaard1, Pia Weikop2, Ulrik Gether1, Mattias Rickhag1 1Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen and Department of Neuroscience and Pharmacology, University of Copenhagen JoVE 56093 Neuroscience
Оценка дофаминергической гомеостаза у мышей с использованием высокопроизводительных жидкостной хроматографии анализа и поглощение синаптосомальных допамина Kathrine L. Jensen1, Annika H. Runegaard1, Pia Weikop2, Ulrik Gether1, Mattias Rickhag1 1Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen and Department of Neuroscience and Pharmacology, University of Copenhagen JoVE 56093 Neuroscience