Wilhelm Haas Massachusetts General Hospital Cancer Center Biography Publications Institution JoVE Articles Wilhelm Haas has not added a biography. If you are Wilhelm Haas and would like to personalize this page please email our Author Liaison for assistance. Publications MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression Across Cancer Cell Line Proteomes Analytical Chemistry. Jun, 2014 | Pubmed ID: 24927332 Grating-based X-ray Phase-contrast Imaging with a Multi Energy-channel Photon-counting Pixel Detector Optics Express. Nov, 2013 | Pubmed ID: 24216793 Quantitative Comparison of the Fasted and Re-fed Mouse Liver Phosphoproteomes Using Lower PH Reductive Dimethylation Methods (San Diego, Calif.). Jun, 2013 | Pubmed ID: 23567750 On a Dark-field Signal Generated by Micrometer-sized Calcifications in Phase-contrast Mammography Physics in Medicine and Biology. Apr, 2013 | Pubmed ID: 23552903 Grating-based Darkfield Imaging of Human Breast Tissue Zeitschrift Für Medizinische Physik. Sep, 2013 | Pubmed ID: 23380071 SUMOylation of Pancreatic Glucokinase Regulates Its Cellular Stability and Activity The Journal of Biological Chemistry. Feb, 2013 | Pubmed ID: 23297408 Accurate Multiplexed Proteomics at the MS2 Level Using the Complement Reporter Ion Cluster Analytical Chemistry. Nov, 2012 | Pubmed ID: 23098179 Increasing the Multiplexing Capacity of TMTs Using Reporter Ion Isotopologues with Isobaric Masses Analytical Chemistry. Sep, 2012 | Pubmed ID: 22880955 Multiplexed in Vivo His-tagging of Enzyme Pathways for in Vitro Single-pot Multienzyme Catalysis ACS Synthetic Biology. Feb, 2012 | Pubmed ID: 22737598 Yin Yang 1 Deficiency in Skeletal Muscle Protects Against Rapamycin-induced Diabetic-like Symptoms Through Activation of Insulin/IGF Signaling Cell Metabolism. Apr, 2012 | Pubmed ID: 22482732 MS3 Eliminates Ratio Distortion in Isobaric Multiplexed Quantitative Proteomics Nature Methods. Nov, 2011 | Pubmed ID: 21963607 Evaluation of HCD- and CID-type Fragmentation Within Their Respective Detection Platforms for Murine Phosphoproteomics Molecular & Cellular Proteomics : MCP. Dec, 2011 | Pubmed ID: 21917720 Noise in X-ray Grating-based Phase-contrast Imaging Medical Physics. Jul, 2011 | Pubmed ID: 21859014 Succinate Dehydrogenase is a Direct Target of Sirtuin 3 Deacetylase Activity PloS One. 2011 | Pubmed ID: 21858060 A Large-scale Method to Measure Absolute Protein Phosphorylation Stoichiometries Nature Methods. Aug, 2011 | Pubmed ID: 21725298 Correct Interpretation of Comprehensive Phosphorylation Dynamics Requires Normalization by Protein Expression Changes Molecular & Cellular Proteomics : MCP. Aug, 2011 | Pubmed ID: 21551504 Proteome-wide Systems Analysis of a Cellulosic Biofuel-producing Microbe Molecular Systems Biology. Jan, 2011 | Pubmed ID: 21245846 A Tissue-specific Atlas of Mouse Protein Phosphorylation and Expression Cell. Dec, 2010 | Pubmed ID: 21183079 Global Phosphorylation Analysis of Beta-arrestin-mediated Signaling Downstream of a Seven Transmembrane Receptor (7TMR) Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010 | Pubmed ID: 20686112 Gas-phase Rearrangements Do Not Affect Site Localization Reliability in Phosphoproteomics Data Sets Journal of Proteome Research. Jun, 2010 | Pubmed ID: 20377248 WDR20 Regulates Activity of the USP12 X UAF1 Deubiquitinating Enzyme Complex The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20147737 Cdc2-like Kinase 2 is an Insulin-regulated Suppressor of Hepatic Gluconeogenesis Cell Metabolism. Jan, 2010 | Pubmed ID: 20074525 GCN5-mediated Transcriptional Control of the Metabolic Coactivator PGC-1beta Through Lysine Acetylation The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19491097 Chaperone-mediated Pathway of Proteasome Regulatory Particle Assembly Nature. Jun, 2009 | Pubmed ID: 19412159 Isolation of Mammalian 26S Proteasomes and P97/VCP Complexes Using the Ubiquitin-like Domain from HHR23B Reveals Novel Proteasome-associated Proteins Biochemistry. Mar, 2009 | Pubmed ID: 19182904 UAF1 is a Subunit of Multiple Deubiquitinating Enzyme Complexes The Journal of Biological Chemistry. Feb, 2009 | Pubmed ID: 19075014 The Impact of Peptide Abundance and Dynamic Range on Stable-isotope-based Quantitative Proteomic Analyses Journal of Proteome Research. Nov, 2008 | Pubmed ID: 18798661 In Situ Observation of Protein Phosphorylation by High-resolution NMR Spectroscopy Nature Structural & Molecular Biology. Mar, 2008 | Pubmed ID: 18297086 A UAF1-containing Multisubunit Protein Complex Regulates the Fanconi Anemia Pathway Molecular Cell. Dec, 2007 | Pubmed ID: 18082604 The Effects of Mass Accuracy, Data Acquisition Speed, and Search Algorithm Choice on Peptide Identification Rates in Phosphoproteomics Analytical and Bioanalytical Chemistry. Nov, 2007 | Pubmed ID: 17874083 Assessing Enzyme Activities Using Stable Isotope Labeling and Mass Spectrometry Molecular & Cellular Proteomics : MCP. Oct, 2007 | Pubmed ID: 17627935 RNAi-dependent and -independent RNA Turnover Mechanisms Contribute to Heterochromatic Gene Silencing Cell. May, 2007 | Pubmed ID: 17512405 Large-scale Phosphorylation Analysis of Alpha-factor-arrested Saccharomyces Cerevisiae Journal of Proteome Research. Mar, 2007 | Pubmed ID: 17330950 Optimization and Use of Peptide Mass Measurement Accuracy in Shotgun Proteomics Molecular & Cellular Proteomics : MCP. Jul, 2006 | Pubmed ID: 16635985 Regulation of Monoubiquitinated PCNA by DUB Autocleavage Nature Cell Biology. Apr, 2006 | Pubmed ID: 16531995 Cdc28-dependent Regulation of the Cdc5/Polo Kinase Current Biology : CB. Nov, 2005 | Pubmed ID: 16303563 Comparative Evaluation of Mass Spectrometry Platforms Used in Large-scale Proteomics Investigations Nature Methods. Sep, 2005 | Pubmed ID: 16118637 Cdk1-dependent Regulation of the Mitotic Inhibitor Wee1 Cell. Aug, 2005 | Pubmed ID: 16096060 The HEAT Repeat Protein Blm10 Regulates the Yeast Proteasome by Capping the Core Particle Nature Structural & Molecular Biology. Apr, 2005 | Pubmed ID: 15778719 Nutrient Control of Glucose Homeostasis Through a Complex of PGC-1alpha and SIRT1 Nature. Mar, 2005 | Pubmed ID: 15744310 Novel 12-deoxy-16-hydroxyphorbol Diesters Isolated from the Seed Oil of Jatropha Curcas Journal of Natural Products. Oct, 2002 | Pubmed ID: 12398539 Traceless Solid-phase Synthesis of Bicyclic Dihydropyrimidones Using Multidirectional Cyclization Cleavage Journal of Combinatorial Chemistry. Sep-Oct, 2002 | Pubmed ID: 12217023 Quantitative Proteomics Using Reductive Dimethylation for Stable Isotope Labeling Andrew C. Tolonen1,2,3, Wilhelm Haas4 1CEA, DSV, IG, Genoscope, 2CNRS-UMR8030, Évry, France, 3Université d'Évry Val d'Essonne, 4Massachusetts General Hospital Cancer Center JoVE 51416 Chemistry
Quantitative Proteomics Using Reductive Dimethylation for Stable Isotope Labeling Andrew C. Tolonen1,2,3, Wilhelm Haas4 1CEA, DSV, IG, Genoscope, 2CNRS-UMR8030, Évry, France, 3Université d'Évry Val d'Essonne, 4Massachusetts General Hospital Cancer Center JoVE 51416 Chemistry