Yossef Av-Gay Department of Medicine University of British Columbia Biography Publications Institution JoVE Articles Yossef Av-Gay has not added a biography. If you are Yossef Av-Gay and would like to personalize this page please email our Author Liaison for assistance. Publications Epigenetic Phosphorylation Control of Mycobacterium Tuberculosis Infection and Persistence Microbiology Spectrum. Mar, 2017 | Pubmed ID: 28281439 Aminorifamycins and Sporalactams Produced in Culture by a Micromonospora Sp. Isolated from a Northeastern-Pacific Marine Sediment Are Potent Antibiotics Organic Letters. Feb, 2017 | Pubmed ID: 28164711 Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium Tuberculosis Cell Reports. Jan, 2016 | Pubmed ID: 26774486 Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms Microbiology Spectrum. Dec, 2015 | Pubmed ID: 27337278 Development of an Intracellular Screen for New Compounds Able To Inhibit Mycobacterium Tuberculosis Growth in Human Macrophages Antimicrobial Agents and Chemotherapy. Oct, 2015 | Pubmed ID: 26503663 Phosphorylation of Mycobacterium Tuberculosis Protein Tyrosine Kinase A PtkA by Ser/Thr Protein Kinases Biochemical and Biophysical Research Communications. Nov, 2015 | Pubmed ID: 26417687 Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium Tuberculosis Growth and Infectivity The Journal of Biological Chemistry. Sep, 2015 | Pubmed ID: 26229105 Immunoevasion and Immunosuppression of the Macrophage by Mycobacterium Tuberculosis Immunological Reviews. Mar, 2015 | Pubmed ID: 25703562 Phosphorylation Control of Protein Tyrosine Phosphatase A Activity in Mycobacterium Tuberculosis FEBS Letters. Jan, 2015 | Pubmed ID: 25535696 Mycobacterium Tuberculosis Promotes Anti-apoptotic Activity of the Macrophage by PtpA Protein-dependent Dephosphorylation of Host GSK3α The Journal of Biological Chemistry. Oct, 2014 | Pubmed ID: 25187516 Microbial Protein-tyrosine Kinases The Journal of Biological Chemistry. Apr, 2014 | Pubmed ID: 24554699 Mycobacterium Tuberculosis Nucleoside Diphosphate Kinase Inactivates Small GTPases Leading to Evasion of Innate Immunity PLoS Pathogens. 2013 | Pubmed ID: 23874203 Gaseous Nitric Oxide Reduces Influenza Infectivity in Vitro Nitric Oxide : Biology and Chemistry. May, 2013 | Pubmed ID: 23562771 Antimicrobial Activity, Cytotoxicity and Inflammatory Response of Novel Plastics Embedded with Silver Nanoparticles Future Microbiology. Mar, 2013 | Pubmed ID: 23464375 Disruption of the Serine/threonine Protein Kinase H Affects Phthiocerol Dimycocerosates Synthesis in Mycobacterium Tuberculosis Microbiology (Reading, England). Apr, 2013 | Pubmed ID: 23412844 Mycobacterium Tuberculosis-secreted Phosphatases: from Pathogenesis to Targets for TB Drug Development Trends in Microbiology. Feb, 2013 | Pubmed ID: 23084287 Chemical Constituents, Anti-inflammatory and Antioxidant Activities of Bark Extracts from Prunus Tucumanensis Lillo Natural Product Research. 2013 | Pubmed ID: 22889184 Mycobacterium Tuberculosis Modulators of the Macrophage's Cellular Events Microbes and Infection. Nov, 2012 | Pubmed ID: 22841679 Antimicrobial, Anti-inflammatory, Antiparasitic, and Cytotoxic Activities of Laennecia Confusa TheScientificWorldJournal. 2012 | Pubmed ID: 22623891 Nitazoxanide Stimulates Autophagy and Inhibits MTORC1 Signaling and Intracellular Proliferation of Mycobacterium Tuberculosis PLoS Pathogens. 2012 | Pubmed ID: 22589723 A Phase I Clinical Study of Inhaled Nitric Oxide in Healthy Adults Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. Jul, 2012 | Pubmed ID: 22520076 The Mycobacterial Transcriptional Regulator WhiB7 Gene Links Redox Homeostasis and Intrinsic Antibiotic Resistance The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22069311 Antibacterial Activity, Inflammatory Response, Coagulation and Cytotoxicity Effects of Silver Nanoparticles Nanomedicine : Nanotechnology, Biology, and Medicine. Apr, 2012 | Pubmed ID: 21718674 Mycobacterium Tuberculosis Protein Tyrosine Phosphatase (PtpA) Excludes Host Vacuolar-H+-ATPase to Inhibit Phagosome Acidification Proceedings of the National Academy of Sciences of the United States of America. Nov, 2011 | Pubmed ID: 22087003 Antimicrobial Activities of Sesquiterpene Lactones and Inositol Derivatives from Hymenoxys Robusta Phytochemistry. Dec, 2011 | Pubmed ID: 21963130 Comparative Efficacy of Commercially Available and Emerging Antimicrobial Urinary Catheters Against Bacteriuria Caused by E. Coli in Vitro Urology. Aug, 2011 | Pubmed ID: 21820571 Coresistance to Isoniazid and Ethionamide Maps to Mycothiol Biosynthetic Genes in Mycobacterium Bovis Antimicrobial Agents and Chemotherapy. Sep, 2011 | Pubmed ID: 21709101 Antimicrobial, Anti-inflammatory, Antiparasitic, and Cytotoxic Activities of Galium Mexicanum Journal of Ethnopharmacology. Sep, 2011 | Pubmed ID: 21586319 Synergistic Drug Combinations for Tuberculosis Therapy Identified by a Novel High-throughput Screen Antimicrobial Agents and Chemotherapy. Aug, 2011 | Pubmed ID: 21576426 Precise Null Deletion Mutations of the Mycothiol Synthesis Genes Reveal Their Role in Isoniazid and Ethionamide Resistance in Mycobacterium Smegmatis Antimicrobial Agents and Chemotherapy. Jul, 2011 | Pubmed ID: 21502624 Antibacterial and Cytotoxic Activities of the Sesquiterpene Lactones Cnicin and Onopordopicrin Natural Product Communications. Feb, 2011 | Pubmed ID: 21425665 MmpS4 Promotes Glycopeptidolipids Biosynthesis and Export in Mycobacterium Smegmatis Molecular Microbiology. Nov, 2010 | Pubmed ID: 21062372 Antimycobacterial Activity of UDP-galactopyranose Mutase Inhibitors International Journal of Antimicrobial Agents. Oct, 2010 | Pubmed ID: 20678902 Convergence of Ser/Thr and Two-component Signaling to Coordinate Expression of the Dormancy Regulon in Mycobacterium Tuberculosis The Journal of Biological Chemistry. Sep, 2010 | Pubmed ID: 20630871 Inhibition of Mycobacterium Tuberculosis Tyrosine Phosphatase PtpA by Synthetic Chalcones: Kinetics, Molecular Modeling, Toxicity and Effect on Growth Bioorganic & Medicinal Chemistry. Jun, 2010 | Pubmed ID: 20462762 Synthesis, Characterization, and Evaluation of Antimicrobial and Cytotoxic Effect of Silver and Titanium Nanoparticles Nanomedicine : Nanotechnology, Biology, and Medicine. Oct, 2010 | Pubmed ID: 20215045 Inositol Monophosphate Phosphatase Genes of Mycobacterium Tuberculosis BMC Microbiology. 2010 | Pubmed ID: 20167072 Slow Release of Nitric Oxide from Charged Catheters and Its Effect on Biofilm Formation by Escherichia Coli Antimicrobial Agents and Chemotherapy. Jan, 2010 | Pubmed ID: 19884372 Protein Kinase and Phosphatase Signaling in Mycobacterium Tuberculosis Physiology and Pathogenesis Biochimica Et Biophysica Acta. Mar, 2010 | Pubmed ID: 19766738 Glutathione Disulfide and S-nitrosoglutathione Detoxification by Mycobacterium Tuberculosis Thioredoxin System FEBS Letters. Oct, 2009 | Pubmed ID: 19737561 Mycobacterium Tuberculosis PtkA is a Novel Protein Tyrosine Kinase Whose Substrate is PtpA The Biochemical Journal. May, 2009 | Pubmed ID: 19366344 The Serine/threonine Protein Kinase PknI Controls the Growth of Mycobacterium Tuberculosis Upon Infection FEMS Microbiology Letters. Jun, 2009 | Pubmed ID: 19341393 Gaseous Nitric Oxide Bactericidal Activity Retained During Intermittent High-dose Short Duration Exposure Nitric Oxide : Biology and Chemistry. Feb, 2009 | Pubmed ID: 18789393 Mycothiol Biosynthesis is Essential for Ethionamide Susceptibility in Mycobacterium Tuberculosis Molecular Microbiology. Sep, 2008 | Pubmed ID: 18651841 Mycobacterium Tuberculosis Virulence is Mediated by PtpA Dephosphorylation of Human Vacuolar Protein Sorting 33B Cell Host & Microbe. May, 2008 | Pubmed ID: 18474358 Molecular Cloning and Biochemical Characterization of a Serine Threonine Protein Kinase, PknL, from Mycobacterium Tuberculosis Protein Expression and Purification. Apr, 2008 | Pubmed ID: 18276158 Mycobacterium Smegmatis Biofilm Formation and Sliding Motility Are Affected by the Serine/threonine Protein Kinase PknF FEMS Microbiology Letters. Jan, 2008 | Pubmed ID: 18031532 Mycobacterium Bovis Bacillus Calmette-Guérin Secreting Active Cathepsin S Stimulates Expression of Mature MHC Class II Molecules and Antigen Presentation in Human Macrophages Journal of Immunology (Baltimore, Md. : 1950). Oct, 2007 | Pubmed ID: 17911599 Comparative Analysis of Mutants in the Mycothiol Biosynthesis Pathway in Mycobacterium Smegmatis Biochemical and Biophysical Research Communications. Nov, 2007 | Pubmed ID: 17826740 Lipoamide Dehydrogenase Mediates Retention of Coronin-1 on BCG Vacuoles, Leading to Arrest in Phagosome Maturation Journal of Cell Science. Aug, 2007 | Pubmed ID: 17652161 Innate Protection of Mycobacterium Smegmatis Against the Antimicrobial Activity of Nitric Oxide is Provided by Mycothiol Antimicrobial Agents and Chemotherapy. Sep, 2007 | Pubmed ID: 17638697 Novel Substrates of Mycobacterium Tuberculosis PknH Ser/Thr Kinase Biochemical and Biophysical Research Communications. Mar, 2007 | Pubmed ID: 17286964 Mycothiol-dependent Proteins in Actinomycetes FEMS Microbiology Reviews. Apr, 2007 | Pubmed ID: 17286835 Mycobacterium Avium Subsp. Paratuberculosis PtpA is an Endogenous Tyrosine Phosphatase Secreted During Infection Infection and Immunity. Dec, 2006 | Pubmed ID: 16982836 Mycobacterium Tuberculosis Transporter MmpL7 is a Potential Substrate for Kinase PknD Biochemical and Biophysical Research Communications. Sep, 2006 | Pubmed ID: 16879801 Mycothiol-dependent Mycobacterial Response to Oxidative Stress FEBS Letters. May, 2006 | Pubmed ID: 16643903 Purification and Characterization of Mycobacterium Tuberculosis 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside Deacetylase, MshB, a Mycothiol Biosynthetic Enzyme Protein Expression and Purification. Jun, 2006 | Pubmed ID: 16630724 In Vitro Properties of Antimicrobial Bromotyrosine Alkaloids Journal of Medical Microbiology. Apr, 2006 | Pubmed ID: 16533988 Mycobacterium Bovis BCG Attenuates Surface Expression of Mature Class II Molecules Through IL-10-dependent Inhibition of Cathepsin S Journal of Immunology (Baltimore, Md. : 1950). Oct, 2005 | Pubmed ID: 16210638 Deletion of the Mycobacterium Tuberculosis PknH Gene Confers a Higher Bacillary Load During the Chronic Phase of Infection in BALB/c Mice Journal of Bacteriology. Aug, 2005 | Pubmed ID: 16077122 Mycobacterial Manipulation of the Host Cell FEMS Microbiology Reviews. Nov, 2005 | Pubmed ID: 16040149 Thiol Specific Oxidative Stress Response in Mycobacteria FEMS Microbiology Letters. Aug, 2005 | Pubmed ID: 16006064 Screening of Compounds Toxicity Against Human Monocytic Cell Line-THP-1 by Flow Cytometry Biological Procedures Online. 2004 | Pubmed ID: 15472722 Targeted Mutagenesis of the Mycobacterium Smegmatis Mca Gene, Encoding a Mycothiol-dependent Detoxification Protein Journal of Bacteriology. Sep, 2004 | Pubmed ID: 15342574 The Mycobacterium Tuberculosis Protein Serine/threonine Kinase PknG is Linked to Cellular Glutamate/glutamine Levels and is Important for Growth in Vivo Molecular Microbiology. Jun, 2004 | Pubmed ID: 15186418 Development of a Liposome Formulation of Ethambutol Antimicrobial Agents and Chemotherapy. May, 2004 | Pubmed ID: 15105152 The Mycobacterium Tuberculosis Ino1 Gene is Essential for Growth and Virulence Molecular Microbiology. Feb, 2004 | Pubmed ID: 14763976 Characterization of Mycobacterium Tuberculosis Mycothiol S-conjugate Amidase Biochemistry. Oct, 2003 | Pubmed ID: 14556638 Kinome Analysis of Host Response to Mycobacterial Infection: a Novel Technique in Proteomics Infection and Immunity. Oct, 2003 | Pubmed ID: 14500469 The Crystal Structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside Deacetylase (MshB) from Mycobacterium Tuberculosis Reveals a Zinc Hydrolase with a Lactate Dehydrogenase Fold The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12958317 The Glycosyltransferase Gene Encoding the Enzyme Catalyzing the First Step of Mycothiol Biosynthesis (mshA) Journal of Bacteriology. Jun, 2003 | Pubmed ID: 12754249 Inactivation of MshB, a Key Gene in the Mycothiol Biosynthesis Pathway in Mycobacterium Smegmatis Microbiology (Reading, England). May, 2003 | Pubmed ID: 12724395 Identification and Characterization of a Diamide Sensitive Mutant of Mycobacterium Smegmatis FEMS Microbiology Letters. Mar, 2003 | Pubmed ID: 12670676 Mycothiol-deficient Mycobacterium Smegmatis Mutants Are Hypersensitive to Alkylating Agents, Free Radicals, and Antibiotics Antimicrobial Agents and Chemotherapy. Nov, 2002 | Pubmed ID: 12384335 Evidence That Plant-like Genes in Chlamydia Species Reflect an Ancestral Relationship Between Chlamydiaceae, Cyanobacteria, and the Chloroplast Genome Research. Aug, 2002 | Pubmed ID: 12176923 Expression and Localization of the Mycobacterium Tuberculosis Protein Tyrosine Phosphatase PtpA Research in Microbiology. May, 2002 | Pubmed ID: 12066895 System for Effekt og Cytotoksisitet Screening av inhibitorer målretting Intracellulær Xingji Zheng1, Yossef Av-Gay1 1Department of Medicine, University of British Columbia JoVE 55273 Immunology and Infection
System for Effekt og Cytotoksisitet Screening av inhibitorer målretting Intracellulær Xingji Zheng1, Yossef Av-Gay1 1Department of Medicine, University of British Columbia JoVE 55273 Immunology and Infection