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Using Chick Embryo Brain as a Model to Study Human Glioblastoma Cell Behavior

May 26, 2023
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Using the Chick Embryo Brain as a Model for In Vivo and Ex Vivo Analyses of Human Glioblastoma Cell Behavior (Video) | JoVE

02:02 min
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Injection of Glioblastoma (GBM) Cells into E5 Optic Tectum In Ovo (Video) | JoVE

02:20 min
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Live Chick Embryo Brain Dissection and Vibratome Slicing (Video) | JoVE

03:52 min
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1Department of Biological Sciences,University of Delaware, 2Helen F. Graham Cancer Center and Research Institute, Christiana Care, 3Department of Neurosurgery, Winthrop P. Rockefeller Cancer Institute,University of Arkansas for Medical Sciences

Summary

Automatic Translation

Chick embryos are used for studying human glioblastoma (GBM) brain tumors in ovo and in ex vivo brain slice co-cultures. GBM cell behavior can be recorded by time-lapse microscopy in ex vivo co-cultures, and both preparations can be analyzed at the experimental endpoint by detailed 3D confocal analysis.

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