Exploring HR-Dependent Cardiac Performance Using an Atrial-Pacing Protocol

July 21, 2023

Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach (Video) | JoVE

01:24 min

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Instrument and Animal Preparation for Catheterization in a Murine Heart Failure Model (Video) | JoVE

01:29 min

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Surgical Procedure for Left Ventricular Catheterization (Open Chest Approach) in a Murine Heart Failure Model (Video) | JoVE

01:11 min

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Determining the End-Systolic and End-Diastolic Pressure-Volume Relationships in a Murine Heart Failure Model and Transesophageal Pacing

03:15 min

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Saline Calibration and Aortic Flow Calibration in a Murine Heart Failure Model (Video) | JoVE

01:14 min

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Genri Numata², Eiki Takimoto³

¹Department of Cardiovascular Medicine,The University of Tokyo Hospital, ²Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine,The University of Tokyo, ³Division of Cardiology, Department of Medicine,The Johns Hopkins Medical Institutions

Summary

The present protocol describes obtaining the pressure-volume relationship through transesophageal pacing, which serves as a valuable tool in evaluating diastolic function in mouse models of heart failure.