Selective Gene Silencing in the Choroid Plexus

June 16, 2023

Knockdown direcionado de genes no plexo coroide

Knockdown específico de ChP de A_2ARs com AAV2/5-shRNA e sistema Cre/LoxP

Yuwen Yang*¹, Chenxing Qi*¹, Lanxin Hu, Cheng Zheng, Xuhang Li, Wu Zheng, Yiyun Weng, Haiyan Lin⁴

¹State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital,Wenzhou Medical University, ²Department of Neurology,the First Affiliated Hospital of Wenzhou Medical University, ³Rehabilitation Medicine Center,The Second Affiliated Hospital of Wenzhou Medical University, ⁴Integrative & Optimized Medicine Research Center, China-USA Institute for Acupuncture and Rehabilitation,Wenzhou Medical University

Summary

Aqui, descrevemos um método para alterar seletivamente a expressão gênica no plexo coroide, evitando qualquer impacto em outras áreas cerebrais.

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