Cerebrospinal Fluid and Blood Withdrawal from Rats with Concurrent EEG Recording

September 01, 2023

Obtaining High-Quality CSF and Blood Samples for Epilepsy Biomarker Discovery (Video) | JoVE

02:18 min

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Tethered Video-EEG in Epileptic Rats for Analyses of Seizure Activity (Video) | JoVE

02:11 min

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Collection of Blood from the Tail Vein of Rats During EEG Recordings (Video) | JoVE

03:18 min

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Collection of Cerebrospinal Fluid from Rat Cisterna Magna During EEG Recordings (Video) | JoVE

03:11 min

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Marie Soukupová, Annunziata Guarino, Laila Asth, Pietro Marino, Mario Barbieri, Michele Simonato, Silvia Zucchini

¹Department of Neuroscience and Rehabilitation, Section of Pharmacology,Universita degli Studi di Ferrara

Summary

The protocol shows repeated cerebrospinal fluid and blood collections from epileptic rats performed in parallel with continuous video-electroencephalogram (EEG) monitoring. These are instrumental for exploring possible links between changes in various body fluid molecules and seizure activity.