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Understanding Tendon Impingement – Murine Explant Model for Studying Mechanobiology

December 08, 2023
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Unraveling the Mechanobiology of Tendon Impingement – A Multiaxial Murine Hind Limb Explant Model (Video) | JoVE

01:32 min
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Explant Dissection to Generate Murine Hind Limb Explant Model to Study Tendon Impingement (Video) | JoVE

02:27 min
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Explant Culture and Platforms Loading to Study the Biologic Sequelae of Tendon Impingement (Video) | JoVE

04:26 min
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1Department of Biomedical Engineering,University of Rochester, 2Department of Orthopaedics, Center for Musculoskeletal Research,University of Rochester Medical Center, 3Department of Pharmacology and Physiology,University of Rochester Medical Center

Summary

Automatic Translation

We present a custom experimental platform and tissue culture protocol that recreates fibrocartilaginous change driven by impingement of the Achilles tendon insertion in murine hind limb explants with sustained cell viability, providing a model suitable for exploring the mechanobiology of tendon impingement.

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