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check_url/66657?article_type=b
Identifying Drugs that Affect Polymerization of Bacterial Cytoskeletal Proteins
April 26, 2024
check_url/66657?article_type=b
裂变酵母作为靶向细菌细胞骨架蛋白的抗菌药物筛选平台
01:18 min
•
check_url/66657?article_type=b
靶向
在裂殖酵
母中表达的 GFP 标记的细菌细胞骨架蛋白和聚合物的显微成像
04:40 min
•
Sakshi Mahesh Poddar
2
,
Srijita Roy
2
,
Ajay Kumar Sharma
2
,
Ramanujam Srinivasan
2
1
School of Biological Sciences
,
National Institute of Science Education and Research
,
2
Homi Bhabha National Institutes
Summary
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裂变酵母在这里用作异源宿主,将细菌细胞骨架蛋白(如 FtsZ 和 MreB)表达为具有 GFP 的翻译融合蛋白,以可视化其聚合。此外,通过使用荧光显微镜进行成像来识别影响聚合的化合物。
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