Advancing Lung Transplantation with PolyhHb-Based Perfusion in Rat EVLP Models

June 14, 2024

Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats

Doug A. Gouchoe*^1,2, Yong Gyu Lee*^1,2, Alisyn Greenfield, Clayton Cuddington, Jung-Lye Kim², Sylvester M. Black, Andre F. Palmer, Bryan A. Whitson²

¹COPPER Laboratory, Department of Surgery,The Ohio State University Wexner Medical Center, ²Division of Cardiac Surgery, Department of Surgery,The Ohio State University Wexner Medical Center, ³William G. Lowrie Department of Chemical and Biomolecular Engineering, College of Engineering,The Ohio State University

Summary

Here, we describe the application of a polymerized human hemoglobin (PolyhHb)-based oxygen carrier as a perfusate and the protocol in which this perfusion solution can be tested in a model of rat ex vivo lung perfusion.

Advancing Lung Transplantation with PolyhHb-Based Perfusion in Rat EVLP Models

Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats

Summary

Article