Assam El-Osta Department of Pathology The University of Melbourne Biography Publications Institution JoVE Articles Assam El-Osta has not added a biography. If you are Assam El-Osta and would like to personalize this page please email our Author Liaison for assistance. Publications Microparticles: Major Transport Vehicles for Distinct MicroRNAs in Circulation Cardiovascular Research. Feb, 2012 | Pubmed ID: 22258631 Influence of Natural and Synthetic Histone Deacetylase Inhibitors on Chromatin Antioxidants & Redox Signaling. Feb, 2012 | Pubmed ID: 22229817 Glycemic Memory Current Opinion in Lipidology. Feb, 2012 | Pubmed ID: 22186662 Molecular Model of Naphthalene-induced DNA Damage in the Murine Lung Human & Experimental Toxicology. Jan, 2012 | Pubmed ID: 21508073 Utility of γH2AX As a Molecular Marker of DNA Double-Strand Breaks in Nuclear Medicine: Applications to Radionuclide Therapy Employing Auger Electron-Emitting Isotopes Current Radiopharmaceuticals. Jan, 2011 | Pubmed ID: 22191615 Protective Effects of Valproic Acid Against Airway Hyperresponsiveness and Airway Remodeling in a Mouse Model of Allergic Airways Disease Epigenetics : Official Journal of the DNA Methylation Society. Dec, 2011 | Pubmed ID: 22139576 Investigation into the Biological Properties of the Olive Polyphenol, Hydroxytyrosol: Mechanistic Insights by Genome-wide MRNA-Seq Analysis Genes & Nutrition. Sep, 2011 | Pubmed ID: 21953375 Genetic Examination of SETD7 and SUV39H1/H2 Methyltransferases and the Risk of Diabetes Complications in Patients with Type 1 Diabetes Diabetes. Nov, 2011 | Pubmed ID: 21896933 Genome-wide Analysis Distinguishes Hyperglycemia Regulated Epigenetic Signatures of Primary Vascular Cells Genome Research. Oct, 2011 | Pubmed ID: 21890681 New Insights into the Pathogenesis of Beckwith-Wiedemann and Silver-Russell Syndromes: Contribution of Small Copy Number Variations to 11p15 Imprinting Defects Human Mutation. Oct, 2011 | Pubmed ID: 21780245 Chromatin Modifying Agents - the Cutting Edge of Anticancer Therapy Drug Discovery Today. Jul, 2011 | Pubmed ID: 21664485 Remodeling is at the Heart of Chromatin: the Heartaches of Chromatin Epigenetics : Official Journal of the DNA Methylation Society. Jul, 2011 | Pubmed ID: 21646860 Cardiac Genes Show Contextual SWI/SNF Interactions with Distinguishable Gene Activities Epigenetics : Official Journal of the DNA Methylation Society. Jun, 2011 | Pubmed ID: 21586902 Histone Deacetylase Inhibitors Augment Doxorubicin-induced DNA Damage in Cardiomyocytes Cellular and Molecular Life Sciences : CMLS. Dec, 2011 | Pubmed ID: 21584806 Evaluation of the Efficacy of Radiation-modifying Compounds Using γH2AX As a Molecular Marker of DNA Double-strand Breaks Genome Integrity. 2011 | Pubmed ID: 21261999 Phosphoinositide 3-kinase As a Novel Functional Target for the Regulation of the Insulin Signaling Pathway by SIRT1 Molecular and Cellular Endocrinology. Mar, 2011 | Pubmed ID: 21241768 Double-strand Breaks and the Concept of Short- and Long-term Epigenetic Memory Chromosoma. Apr, 2011 | Pubmed ID: 21174214 Genetic and Epigenetic Events in Diabetic Wound Healing International Wound Journal. Feb, 2011 | Pubmed ID: 21159125 Atherogenic Factors and Their Epigenetic Relationships International Journal of Vascular Medicine. 2010 | Pubmed ID: 21152193 Epigenetics: Mechanisms and Implications for Diabetic Complications Circulation Research. Dec, 2010 | Pubmed ID: 21148447 Histone Modifications Regulate the Norepinephrine Transporter Gene Cell Cycle (Georgetown, Tex.). Nov, 2010 | Pubmed ID: 21088495 Epigenetic Phenomena Linked to Diabetic Complications Nature Reviews. Endocrinology. Dec, 2010 | Pubmed ID: 21045787 Trichostatin A Accentuates Doxorubicin-induced Hypertrophy in Cardiac Myocytes Aging. Oct, 2010 | Pubmed ID: 20930262 Glycemic Memory Associated Epigenetic Changes Biochemical Pharmacology. Dec, 2010 | Pubmed ID: 20599797 Metabolic Memory and Diabetic Nephropathy: Potential Role for Epigenetic Mechanisms Nature Reviews. Nephrology. Jun, 2010 | Pubmed ID: 20421885 Downstream Targets of Methyl CpG Binding Protein 2 and Their Abnormal Expression in the Frontal Cortex of the Human Rett Syndrome Brain BMC Neuroscience. 2010 | Pubmed ID: 20420693 GammaH2AX As a Molecular Marker of Aging and Disease Epigenetics : Official Journal of the DNA Methylation Society. Feb, 2010 | Pubmed ID: 20150765 Alleviating Transcriptional Inhibition of the Norepinephrine Slc6a2 Transporter Gene in Depolarized Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2010 | Pubmed ID: 20107077 Cardiac Ventricular Chambers Are Epigenetically Distinguishable Cell Cycle (Georgetown, Tex.). Feb, 2010 | Pubmed ID: 20090419 Analysis of the IGF2/H19 Imprinting Control Region Uncovers New Genetic Defects, Including Mutations of OCT-binding Sequences, in Patients with 11p15 Fetal Growth Disorders Human Molecular Genetics. Mar, 2010 | Pubmed ID: 20007505 Epigenetic Regulation of Multidrug Resistance 1 Gene Expression: Profiling CpG Methylation Status Using Bisulphite Sequencing Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 19949925 Gamma-radiation-induced GammaH2AX Formation Occurs Preferentially in Actively Transcribing Euchromatic Loci Cellular and Molecular Life Sciences : CMLS. Jan, 2010 | Pubmed ID: 19859659 The Emerging Role of Epigenetic Modifications and Chromatin Remodeling in Spinal Muscular Atrophy Journal of Neurochemistry. Jun, 2009 | Pubmed ID: 19383090 Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated with Gene-activating Epigenetic Marks That Coexist on the Lysine Tail Diabetes. May, 2009 | Pubmed ID: 19208907 Survival Motor Neuron Gene 2 Silencing by DNA Methylation Correlates with Spinal Muscular Atrophy Disease Severity and Can Be Bypassed by Histone Deacetylase Inhibition Human Molecular Genetics. Jan, 2009 | Pubmed ID: 18971205 Human Sympathetic Nerve Biology: Parallel Influences of Stress and Epigenetics in Essential Hypertension and Panic Disorder Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19120127 Transient High Glucose Causes Persistent Epigenetic Changes and Altered Gene Expression During Subsequent Normoglycemia The Journal of Experimental Medicine. Sep, 2008 | Pubmed ID: 18809715 Epigenetic Regulation and Fetal Programming Best Practice & Research. Clinical Endocrinology & Metabolism. Feb, 2008 | Pubmed ID: 18279777 Effect of Valproic Acid on Radiation-induced DNA Damage in Euchromatic and Heterochromatic Compartments Cell Cycle (Georgetown, Tex.). Feb, 2008 | Pubmed ID: 18239454 FOXO1 Regulates the Expression of 4E-BP1 and Inhibits MTOR Signaling in Mammalian Skeletal Muscle The Journal of Biological Chemistry. Jul, 2007 | Pubmed ID: 17510058 The Epigenetic Modifier, Valproic Acid, Enhances Radiation Sensitivity Epigenetics : Official Journal of the DNA Methylation Society. Jul-Sep, 2006 | Pubmed ID: 17965607 Clinical Potential of Histone Deacetylase Inhibitors As Stand Alone Therapeutics and in Combination with Other Chemotherapeutics or Radiotherapy for Cancer Epigenetics : Official Journal of the DNA Methylation Society. Jul-Sep, 2006 | Pubmed ID: 17965606 The Neuronal Noradrenaline Transporter, Anxiety and Cardiovascular Disease Journal of Psychopharmacology (Oxford, England). Jul, 2006 | Pubmed ID: 16785272 The Paradox of Histone Deacetylase Inhibitor-mediated Modulation of Cellular Responses to Radiation Cell Cycle (Georgetown, Tex.). Feb, 2006 | Pubmed ID: 16418577 Mechanisms of Abnormal Gene Expression in Tumor Cells EXS. 2006 | Pubmed ID: 16383026 Epigenetic Changes to the MDR1 Locus in Response to Chemotherapeutic Drugs Oncogene. Dec, 2005 | Pubmed ID: 16091741 The Histone Deacetylase Inhibitor, Trichostatin A, Enhances Radiation Sensitivity and Accumulation of GammaH2A.X Cancer Biology & Therapy. Jul, 2005 | Pubmed ID: 16082178 Modulation of Soluble Receptor for Advanced Glycation End Products by Angiotensin-converting Enzyme-1 Inhibition in Diabetic Nephropathy Journal of the American Society of Nephrology : JASN. Aug, 2005 | Pubmed ID: 15930093 RNA Interference and Potential Therapeutic Applications of Short Interfering RNAs Cancer Gene Therapy. Oct, 2005 | Pubmed ID: 15891770 Brahma Links the SWI/SNF Chromatin-remodeling Complex with MeCP2-dependent Transcriptional Silencing Nature Genetics. Mar, 2005 | Pubmed ID: 15696166 DNA Damage Detection and Repair, and the Involvement of Epigenetic States Human Mutation. Feb, 2005 | Pubmed ID: 15643607 Demethylation Using the Epigenetic Modifier, 5-azacytidine, Increases the Efficiency of Transient Transfection of Macrophages Journal of Lipid Research. Feb, 2005 | Pubmed ID: 15520456 SiRNAs: Mechanism of RNA Interference, in Vivo and Potential Clinical Applications Cancer Biology & Therapy. Nov, 2004 | Pubmed ID: 15539939 Expression Analysis of the Epigenetic Methyltransferases and Methyl-CpG Binding Protein Families in the Normal B-cell and B-cell Chronic Lymphocytic Leukemia (CLL) Cancer Biology & Therapy. Oct, 2004 | Pubmed ID: 15467427 MDR1, Chemotherapy and Chromatin Remodeling Cancer Biology & Therapy. Sep, 2004 | Pubmed ID: 15326379 Understanding the Consequences of Epigenetic Mechanisms and Its Effects on Transcription in Health and Disease Cancer Biology & Therapy. Sep, 2004 | Pubmed ID: 15326369 Epigenetic Changes Activate Widespread Signals in Response to Double-strand Breaks Cancer Biology & Therapy. Jul, 2004 | Pubmed ID: 15136760 The Rise and Fall of Genomic Methylation in Cancer Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K. Feb, 2004 | Pubmed ID: 14628069 DNMT Cooperativity--the Developing Links Between Methylation, Chromatin Structure and Cancer BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Nov, 2003 | Pubmed ID: 14579248 The Rise of DNA Methylation and the Importance of Chromatin on Multidrug Resistance in Cancer Experimental Cell Research. Nov, 2003 | Pubmed ID: 14567978 On the Use of DNA Methylation Inhibitors and the Reversal of Transcriptional Silencing Blood. Feb, 2003 | Pubmed ID: 12560246 FMR1 Silencing and the Signals to Chromatin: a Unified Model of Transcriptional Regulation Biochemical and Biophysical Research Communications. Jul, 2002 | Pubmed ID: 12099676 Precipitous Release of Methyl-CpG Binding Protein 2 and Histone Deacetylase 1 from the Methylated Human Multidrug Resistance Gene (MDR1) on Activation Molecular and Cellular Biology. Mar, 2002 | Pubmed ID: 11865062 Clonogenic Assay: Adherent Cells Haloom Rafehi1,2, Christian Orlowski1,2,3, George T. Georgiadis1, Katherine Ververis1,4, Assam El-Osta2,3, Tom C. Karagiannis1,2 1Epigenomic Medicine, BakerIDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 2Department of Pathology, The University of Melbourne, 3Epigenetics in Human Health and Disease, BakerIDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 4Department of Anatomy and Cellular Biology, The University of Melbourne JoVE 2573 生物学 Evaluation of the Spatial Distribution of γH2AX following Ionizing Radiation Raja S. Vasireddy1,2,3, Michelle M. Tang1,2, Li-Jeen Mah2,3, George T. Georgiadis2, Assam El-Osta1,3, Tom C. Karagiannis2,3 1Epigenetics in Human Health and Disease, BakerIDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 2Epigenomic Medicine, BakerIDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 3Department of Pathology, University of Melbourne JoVE 2203 生物学 Quantitation of γH2AX Foci in Tissue Samples Michelle M. Tang1,2, Li-Jeen Mah1,3, Raja S. Vasireddy1,2,3, George T. Georgiadis1, Assam El-Osta2,3, Simon G. Royce3,4,5, Tom C. Karagiannis1,3 1Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 2Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 3Department of Pathology, The University of Melbourne, 4Department of Allergy and Immunology, Murdoch Children's Research Institute, Royal Children's Hospital, 5Department of Pediatrics, The University of Melbourne JoVE 2063 生物学 Quantification of γH2AX Foci in Response to Ionising Radiation Li-Jeen Mah1,2, Raja S. Vasireddy1,2,3, Michelle M. Tang1,3, George T. Georgiadis1, Assam El-Osta2,3, Tom C. Karagiannis1,2 1Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 2Department of Pathology, The University of Melbourne, 3Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct JoVE 1957 生物学
Clonogenic Assay: Adherent Cells Haloom Rafehi1,2, Christian Orlowski1,2,3, George T. Georgiadis1, Katherine Ververis1,4, Assam El-Osta2,3, Tom C. Karagiannis1,2 1Epigenomic Medicine, BakerIDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 2Department of Pathology, The University of Melbourne, 3Epigenetics in Human Health and Disease, BakerIDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 4Department of Anatomy and Cellular Biology, The University of Melbourne JoVE 2573 生物学
Evaluation of the Spatial Distribution of γH2AX following Ionizing Radiation Raja S. Vasireddy1,2,3, Michelle M. Tang1,2, Li-Jeen Mah2,3, George T. Georgiadis2, Assam El-Osta1,3, Tom C. Karagiannis2,3 1Epigenetics in Human Health and Disease, BakerIDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 2Epigenomic Medicine, BakerIDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 3Department of Pathology, University of Melbourne JoVE 2203 生物学
Quantitation of γH2AX Foci in Tissue Samples Michelle M. Tang1,2, Li-Jeen Mah1,3, Raja S. Vasireddy1,2,3, George T. Georgiadis1, Assam El-Osta2,3, Simon G. Royce3,4,5, Tom C. Karagiannis1,3 1Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 2Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 3Department of Pathology, The University of Melbourne, 4Department of Allergy and Immunology, Murdoch Children's Research Institute, Royal Children's Hospital, 5Department of Pediatrics, The University of Melbourne JoVE 2063 生物学
Quantification of γH2AX Foci in Response to Ionising Radiation Li-Jeen Mah1,2, Raja S. Vasireddy1,2,3, Michelle M. Tang1,3, George T. Georgiadis1, Assam El-Osta2,3, Tom C. Karagiannis1,2 1Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 2Department of Pathology, The University of Melbourne, 3Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct JoVE 1957 生物学