Investigating HFpEF Pathophysiology in a Hyperlipidemia-Induced Mouse Model

March 29, 2024

射血分数保留的高脂血症诱导心力衰竭小鼠模型

诱导高脂血症以表征 HFpEF 小鼠舒张功能障碍

Monique Williams², Ali Kamiar³, Jose Manuel Condor Capcha², Monica Anne Rasmussen, Qusai Alitter, Rosemeire Kanashiro Takeuchi³, Lauro Mitsuru Takeuchi, Joshua M. Hare², Lina A. Shehadeh²

¹Department of Medicine, Division of Cardiology,University of Miami Leonard M. Miller School of Medicine, ²Interdisciplinary Stem Cell Institute,University of Miami Leonard M. Miller School of Medicine, ³Department of Molecular and Cellular Pharmacology,University of Miami Leonard M. Miller School of Medicine, ⁴Department of Medical Education,University of Miami Leonard M. Miller School of Medicine

Summary

该协议提出了一种详细的方法，用于复制高脂血症诱导的射血分数保留（HFpEF）的小鼠模型。该设计结合了腺相关病毒 9-心肌肌钙蛋白 T 低密度脂蛋白受体（AAV9-cTnT-LDLR）和泊洛沙姆-407 （P-407）的给药。

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