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Journal / Bioengineering / An Injectable and Drug-loaded Supramolecular…
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Bioengineering

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JoVE Journal Bioengineering
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
 

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Article DOI: 10.3791/52450-v • 10:28 min • June 7th, 2015
June 7th, 2015 •
*1, *1, 2, 1, 2, 2, 2, 1
1Institute for Complex Molecular Systems, Department of Biomedical Engineering, Laboratory of Chemical Biology, Eindhoven University of Technology, 2Department of Cardiology, Division Heart and Lungs, Interuniversity Cardiology Institute of the Netherlands (ICIN), University Medical Center Utrecht
* These authors contributed equally

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Supramolecular hydrogelators based on ureido-pyrimidinones allow full control over the macroscopic gel properties and the sol–gel switching behavior using pH. Here, we present a protocol for formulating and injecting such a supramolecular hydrogelator via a catheter delivery system for local delivery directly in relevant areas in the pig heart.

Tags

Injectable Drug-loaded Supramolecular Hydrogel Local Catheter Injection Pig Heart Myocardium Regeneration Chronic Ischemic Heart Failure Donor Hearts Local Drug Delivery Bioactives Hydrogel Formulation Non-invasive Injection Side-specific Treatment 3-D Electromechanical Mapping Catheter Use Ureido-pyrimidinone Modified Poly(ethylene Glycol) Newtonian Fluid Gel To Solution State Switching Bioactive Drugs Growth Factors Exosomes In Vitro Experiments In Vivo Experiments
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