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Cancer Research

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JoVE Journal Cancer Research
Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
 

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Article DOI: 10.3791/56327-v • 06:44 min • September 8th, 2017
September 8th, 2017 •
1, 1, 1, 1, 1, 1,2
1Department of Pathology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 2Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai

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Resistance to cancer therapies contributes to disease progression and death. Determining the mechanistic underpinnings of resistance is crucial for improving therapeutic response. This manuscript details the protocol to generate taxane-resistant cell models of prostate cancer (PC) to help dissecting the pathways involved in progression to Docetaxel resistance in PC patients.

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Prostate Cancer Cell Models Resistance Anti-mitotic Agent Docetaxel Cancer Cell Biology Genomic Fields Signaling Pathways Disease Progression Targetable Strategies Experimental Models Anti-cancer Drug Responses Patient Tumor Samples Animal Models DU145 Cells 22Rv1 Cells Nanomolar Concentration Clones Appearance PBS Trypsin-EDTA
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