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局部性乳酸酶诱导下降胸腔主动脉瘤的毛尿外科模型

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JoVE 杂志医学

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

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局部性乳酸酶诱导下降胸腔主动脉瘤的毛尿外科模型

DOI:

10.3791/60105-v

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00:08 min

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August 24, 2019

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Zachary Tyerman, Jolian Dahl, Alexander Shannon, W. Forrest Johnston, Nicholas H. Pope, Guanyi Lu, Gilbert R. Upchurch Jr., Gorav Ailawadi⁴, Morgan Salmon

¹Department of Surgery,University of Virginia School of Medicine, ²Department of Surgery,Ochsner Medical Center, ³Department of Surgery,University of Florida, ⁴The Robert M. Berne Cardiovascular Research Center,University of Virginia School of Medicine

Chapters

00:04Title
00:33Mouse Position Preparation
01:09Thorax Entry
02:24Aortic Exposure
03:04Elastase Exposure
03:48Chest Closure and Recovery
04:28Thoracic Aortic Aneurysm (TAA) Harvest
06:58Results: Representative Effects of TAA Formation
07:54Conclusion

Summary

自动翻译

我们描述了一个手术方案，以持续诱导小鼠强健的胸主动脉瘤。手术包括左胸切除术、胸主动脉暴露，以及将浸泡在猪胰腺内酶的海绵放在主动脉壁上。

Tags

Keywords: Murine Surgical Model Topical Elastase Descending Thoracic Aortic Aneurysm C57 Black Six Mouse Thoracotomy Aortic Dissection Porcine Pancreatic Elastase

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