Alexander Quaas Institute of Pathology University Hospital Cologne Biography Publications Institution JoVE Articles Alexander Quaas has not added a biography. If you are Alexander Quaas and would like to personalize this page please email our Author Liaison for assistance. Publications Hemangiosis Carcinomatosa As an Independent Risk Factor for Long-term Survival in Non-Small Cell Lung Cancer Patients Surgical Oncology. Jun, 2022 | Pubmed ID: 35738083 Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response, Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice International Journal of Molecular Sciences. May, 2022 | Pubmed ID: 35628414 Influence of Patient Sex on Outcomes After Pancreatic Surgery: Multicentre Study The British Journal of Surgery. May, 2022 | Pubmed ID: 35574811 Fructose-1,6-bisphosphatase 1 (FBP1) is an Independent Biomarker Associated with a Favorable Prognosis in Esophageal Adenocarcinoma Journal of Cancer Research and Clinical Oncology. Apr, 2022 | Pubmed ID: 35477823 COVID-19 Infection Induce MiR-371a-3p Upregulation Resulting in Influence on Male Fertility Biomedicines. Apr, 2022 | Pubmed ID: 35453608 Long-Term Outcome After Histopathological Complete Response with and Without Nodal Metastases Following Multimodal Treatment of Esophageal Cancer Annals of Surgical Oncology. Apr, 2022 | Pubmed ID: 35403919 Organ Manifestations of COVID-19: What Have We Learned So Far (not Only) from Autopsies? Virchows Archiv : an International Journal of Pathology. Apr, 2022 | Pubmed ID: 35364700 International Tumor Budding Consensus Conference Criteria Determine the Prognosis of Oesophageal Adenocarcinoma with Poor Response to Neoadjuvant Treatment Pathology, Research and Practice. Apr, 2022 | Pubmed ID: 35316631 Expression of Neighbor of Punc E11 (NOPE) in Early Stage Esophageal Adenocarcinoma is Associated with Reduced Survival Scientific Reports. 03, 2022 | Pubmed ID: 35246597 Post-transplant Malignancies Show Reduced T-cell Abundance and Tertiary Lymphoid Structures As Correlates of Impaired Cancer Immunosurveillance Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 04, 2022 | Pubmed ID: 35191474 Deep Learning Based on Hematoxylin-eosin Staining Outperforms Immunohistochemistry in Predicting Molecular Subtypes of Gastric Adenocarcinoma The Journal of Pathology. 06, 2022 | Pubmed ID: 35119111 Placental Growth Factor Promotes Tumour Desmoplasia and Treatment Resistance in Intrahepatic Cholangiocarcinoma Gut. 01, 2022 | Pubmed ID: 33431577 Genotype Distribution and Prevalence of Human Papillomavirus in Head and Neck Cancer Samples from Istanbul, Turkey Pathogens (Basel, Switzerland). Nov, 2021 | Pubmed ID: 34959488 IL-17B/RB Activation in Pancreatic Stellate Cells Promotes Pancreatic Cancer Metabolism and Growth Cancers. Oct, 2021 | Pubmed ID: 34771503 A Novel Hybrid Stent with Endoscopic Vacuum Therapy for Treating Leaks of the Upper Gastrointestinal Tract Visceral Medicine. Oct, 2021 | Pubmed ID: 34722723 MAPK-pathway Inhibition Mediates Inflammatory Reprogramming and Sensitizes Tumors to Targeted Activation of Innate Immunity Sensor RIG-I Nature Communications. 09, 2021 | Pubmed ID: 34535668 Genomic and Transcriptomic Characteristics of Esophageal Adenocarcinoma Cancers. Aug, 2021 | Pubmed ID: 34503107 Development and Validation of Deep Learning Classifiers to Detect Epstein-Barr Virus and Microsatellite Instability Status in Gastric Cancer: a Retrospective Multicentre Cohort Study The Lancet. Digital Health. 10, 2021 | Pubmed ID: 34417147 Occurrence of High Microsatellite-Instability/Mismatch Repair Deficiency in Nearly 2,000 Human Adenocarcinomas of the Gastrointestinal Tract, Pancreas, and Bile Ducts: A Study From a Large German Comprehensive Cancer Center Frontiers in Oncology. 2021 | Pubmed ID: 34367937 Quality Control Stress Test for Deep Learning-based Diagnostic Model in Digital Pathology Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. 12, 2021 | Pubmed ID: 34168282 First Description of Hematogenously Metastasized Sclerosing Epithelioid Fibrosarcoma Arising in the Uterine Cervix Gynecologic Oncology Reports. Aug, 2021 | Pubmed ID: 34159243 CD86 Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses Cancer Immunology Research. 09, 2021 | Pubmed ID: 34155067 Cancer-specific Immune Evasion and Substantial Heterogeneity Within Cancer Types Provide Evidence for Personalized Immunotherapy NPJ Precision Oncology. Jun, 2021 | Pubmed ID: 34135436 Maternal Exercise Mediates Hepatic Metabolic Programming Via Activation of AMPK-PGC1α Axis in the Offspring of Obese Mothers Cells. 05, 2021 | Pubmed ID: 34069390 Sex-specific Prognostic Effect of CD66b-positive Tumor-infiltrating Neutrophils (TANs) in Gastric and Esophageal Adenocarcinoma Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 11, 2021 | Pubmed ID: 34009535 Optimized PD-L1 Scoring of Gastric Cancer Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 09, 2021 | Pubmed ID: 33954872 Trophoblast Cell Surface Antigen 2 (Trop-2) Protein is Highly Expressed in Salivary Gland Carcinomas and Represents a Potential Therapeutic Target Head and Neck Pathology. Dec, 2021 | Pubmed ID: 33886073 Protein-loss of SWI/SNF-complex Core Subunits Influences Prognosis Dependent on Histological Subtypes of Intra- and Extrahepatic Cholangiocarcinoma Oncology Letters. May, 2021 | Pubmed ID: 33747206 Tumor Infiltrating Lymphocyte Clusters Are Associated with Response to Immune Checkpoint Inhibition in BRAF V600 Mutated Malignant Melanomas Scientific Reports. 01, 2021 | Pubmed ID: 33469107 Deep Learning Predicts HPV Association in Oropharyngeal Squamous Cell Carcinomas and Identifies Patients with a Favorable Prognosis Using Regular H&E Stains Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 02, 2021 | Pubmed ID: 33262137 Microwave Ablation Enhances Tumor-specific Immune Response in Patients with Hepatocellular Carcinoma Cancer Immunology, Immunotherapy : CII. Apr, 2021 | Pubmed ID: 33006650 Tumor Budding Assessed According to the Criteria of the International Tumor Budding Consensus Conference Determines Prognosis in Resected Esophageal Adenocarcinoma Virchows Archiv : an International Journal of Pathology. Mar, 2021 | Pubmed ID: 32761393 LAG-3, TIM-3 and VISTA Expression on Tumor-Infiltrating Lymphocytes in Oropharyngeal Squamous Cell Carcinoma-Potential Biomarkers for Targeted Therapy Concepts International Journal of Molecular Sciences. Dec, 2020 | Pubmed ID: 33396515 Deep Learning for Sensitive Detection of Helicobacter Pylori in Gastric Biopsies BMC Gastroenterology. Dec, 2020 | Pubmed ID: 33308189 GATA Binding Protein 6 (GATA6) is Co-amplified with PIK3CA in Patients with Esophageal Adenocarcinoma and is Linked to Neoadjuvant Therapy Journal of Cancer Research and Clinical Oncology. Dec, 2020 | Pubmed ID: 33300112 Regorafenib Combined with PD1 Blockade Increases CD8 T-cell Infiltration by Inducing CXCL10 Expression in Hepatocellular Carcinoma Journal for Immunotherapy of Cancer. 11, 2020 | Pubmed ID: 33234602 Interferon-Induced Protein With Multiple Tetratricopeptide Repeats 3 Is Associated With Response to Chemotherapy and Recurrence but Not With Survival Pancreas. Nov/Dec, 2020 | Pubmed ID: 33122518 ATP Synthase Modulation Leads to an Increase of Spare Respiratory Capacity in HPV Associated Cancers Scientific Reports. 10, 2020 | Pubmed ID: 33060693 Indoleamine 2,3-Dioxygenase (IDO) Expression Is an Independent Prognostic Marker in Esophageal Adenocarcinoma Journal of Immunology Research. 2020 | Pubmed ID: 33029538 Maternal Exercise Conveys Protection Against NAFLD in the Offspring Via Hepatic Metabolic Programming Scientific Reports. 09, 2020 | Pubmed ID: 32963289 Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 11, 2020 | Pubmed ID: 32817080 PD-L1 Expression and a High Tumor Infiltrate of CD8+ Lymphocytes Predict Outcome in Patients with Oropharyngeal Squamous Cells Carcinoma International Journal of Molecular Sciences. Jul, 2020 | Pubmed ID: 32718057 Y Chromosome Loss is a Frequent Event in Barrett's Adenocarcinoma and Associated with Poor Outcome Cancers. Jun, 2020 | Pubmed ID: 32629877 Amplification of KRAS and Its Heterogeneity in Non-Asian Gastric Adenocarcinomas BMC Cancer. Jun, 2020 | Pubmed ID: 32571252 Cell Type-specific Transcriptomics of Esophageal Adenocarcinoma As a Scalable Alternative for Single Cell Transcriptomics Molecular Oncology. 06, 2020 | Pubmed ID: 32255255 Immune Profile and Immunosurveillance in Treatment-naive and Neoadjuvantly Treated Esophageal Adenocarcinoma Cancer Immunology, Immunotherapy : CII. Apr, 2020 | Pubmed ID: 31960110 Diagnostic Challenges and Treatment Options for Cutaneous T Cell Pseudolymphoma: A Case Study with Rituximab Treatment The American Journal of Case Reports. Jan, 2020 | Pubmed ID: 31919337 PIK3CA and KRAS Amplification In Esophageal Adenocarcinoma and Their Impact on the Inflammatory Tumor Microenvironment and Prognosis Translational Oncology. Feb, 2020 | Pubmed ID: 31865178 First Report on Two Cases of Pleomorphic Dermal Sarcoma Successfully Treated with Immune Checkpoint Inhibitors Oncoimmunology. 2019 | Pubmed ID: 31741767 Upregulation of MiR-17-92 Cluster is Associated with Progression and Lymph Node Metastasis in Oesophageal Adenocarcinoma Scientific Reports. 08, 2019 | Pubmed ID: 31431687 Immune-phenotyping of Pleomorphic Dermal Sarcomas Suggests This Entity As a Potential Candidate for Immunotherapy Cancer Immunology, Immunotherapy : CII. Jun, 2019 | Pubmed ID: 30963193 Successful Use of TNFα Blockade in a Severe Case of Idiopathic Non-granulomatous Ulcerative Jejunoileitis Associated with Thrombotic Thrombocytopenic Purpura BMJ Open Gastroenterology. 2019 | Pubmed ID: 30899536 P53 Overexpression is a Prognosticator of Poor Outcome in Esophageal Cancer Oncology Letters. Apr, 2019 | Pubmed ID: 30881503 Tumor-associated B Cells and Humoral Immune Response in Head and Neck Squamous Cell Carcinoma Oncoimmunology. 2019 | Pubmed ID: 30723574 Alterations in ERBB2 and BRCA and Microsatellite Instability As New Personalized Treatment Options in Small Bowel Carcinoma BMC Gastroenterology. Feb, 2019 | Pubmed ID: 30717682 HER2/neu (ERBB2) Expression and Gene Amplification Correlates with Better Survival in Esophageal Adenocarcinoma BMC Cancer. Jan, 2019 | Pubmed ID: 30621632 Genomic Characterization of TP53-Wild-Type Esophageal Carcinoma Translational Oncology. Jan, 2019 | Pubmed ID: 30317074 Somatic Alterations in Circulating Cell-free DNA of Oesophageal Carcinoma Patients During Primary Staging Are Indicative for Post-surgical Tumour Recurrence Scientific Reports. 10, 2018 | Pubmed ID: 30297788 Immunohistochemical Expression of Melanocytic and Myofibroblastic Markers and Their Molecular Correlation in Atypical Fibroxanthomas and Pleomorphic Dermal Sarcomas Journal of Cutaneous Pathology. Dec, 2018 | Pubmed ID: 30155964 Therapy Susceptible Germline-related BRCA 1-mutation in a Case of Metastasized Mixed Adeno-neuroendocrine Carcinoma (MANEC) of the Small Bowel BMC Gastroenterology. May, 2018 | Pubmed ID: 29855275 Gene Amplification is a Rare Event in Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma Oncotarget. Apr, 2018 | Pubmed ID: 29765529 Low SOX2 Expression Marks a Distinct Subset of Adenoid Cystic Carcinoma of the Head and Neck and is Associated with an Advanced Tumor Stage PloS One. 2018 | Pubmed ID: 29596469 Copy Number Variations in Atypical Fibroxanthomas and Pleomorphic Dermal Sarcomas Oncotarget. Dec, 2017 | Pubmed ID: 29312620 New Concepts of Personalized Therapy in Salivary Gland Carcinomas Oral Oncology. 05, 2017 | Pubmed ID: 28325631 MDM2 and CDK4 Amplifications Are Rare Events in Salivary Duct Carcinomas Oncotarget. Nov, 2016 | Pubmed ID: 27662657 Oncogene and Therapeutic Target Analyses in Atypical Fibroxanthomas and Pleomorphic Dermal Sarcomas Oncotarget. Apr, 2016 | Pubmed ID: 26943575 Sous-culture et cryoconservation des organoïdes de l’adénocarcinome œsophagien: avantages et inconvénients de la digestion unicellulaire Ningbo Fan*1, Lisa Raatz*1, Seung-Hun Chon1, Alexander Quaas2, Christiane Bruns1, Yue Zhao1 1Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, 2Institute of Pathology, University Hospital Cologne JoVE 63281 Krebsforschung
Sous-culture et cryoconservation des organoïdes de l’adénocarcinome œsophagien: avantages et inconvénients de la digestion unicellulaire Ningbo Fan*1, Lisa Raatz*1, Seung-Hun Chon1, Alexander Quaas2, Christiane Bruns1, Yue Zhao1 1Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, 2Institute of Pathology, University Hospital Cologne JoVE 63281 Krebsforschung