Alfred Fahr Department of Pharmaceutical Technology Friedrich-Schiller-University Jena Biography Publications Institution JoVE Articles Alfred Fahr has not added a biography. If you are Alfred Fahr and would like to personalize this page please email our Author Liaison for assistance. Publications Spontaneous Encapsulation and Concentration of Biological Macromolecules in Liposomes: an Intriguing Phenomenon and Its Relevance in Origins of Life Journal of Molecular Evolution. Dec, 2014 | Pubmed ID: 25416509 Electron Microscopy and Theoretical Modeling of Cochleates Langmuir : the ACS Journal of Surfaces and Colloids. Nov, 2014 | Pubmed ID: 25318049 Photodynamic Killing of Enterococcus Faecalis in Dentinal Tubules Using MTHPC Incorporated in Liposomes and Invasomes Clinical Oral Investigations. Jun, 2014 | Pubmed ID: 24950607 In Vivo Near-infrared Fluorescence Imaging of FAP-expressing Tumors with Activatable FAP-targeted, Single-chain Fv-immunoliposomes Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2014 | Pubmed ID: 24810115 Asymmetric Flow Field-flow Fractionation in the Field of Nanomedicine Analytical Chemistry. Jun, 2014 | Pubmed ID: 24802650 Study of PK Values and Effective Dielectric Constants of Ionizable Residues in Pentapeptides and in Staphylococcal Nuclease (SNase) Using a Mean-field Approach The Journal of Physical Chemistry. B. Apr, 2014 | Pubmed ID: 24708515 Influence of Massage and Occlusion on the Ex Vivo Skin Penetration of Rigid Liposomes and Invasomes European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Feb, 2014 | Pubmed ID: 24252713 [FeFe]-hydrogenase Models Assembled into Vesicular Structures Journal of Liposome Research. Mar, 2014 | Pubmed ID: 24006843 Novel Insights into Appropriate Encapsulation Methods for Bioactive Compounds into Polymers: a Study with Peptides and HDAC Inhibitors Macromolecular Bioscience. Jan, 2014 | Pubmed ID: 23966296 A Remarkable Self-organization Process As the Origin of Primitive Functional Cells Angewandte Chemie (International Ed. in English). Dec, 2013 | Pubmed ID: 24130192 Lipid Colloidal Carriers for Improvement of Anticancer Activity of Orally Delivered Quercetin: Formulation, Characterization and Establishing in Vitro-in Vivo Advantage Journal of Biomedical Nanotechnology. Jul, 2013 | Pubmed ID: 23909137 Comparative SAXS and DSC Study on Stratum Corneum Structural Organization in an Epidermal Cell Culture Model (ROC): Impact of Cultivation Time European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Dec, 2013 | Pubmed ID: 23770376 Non-invasive Depth Profile Imaging of the Stratum Corneum Using Confocal Raman Microscopy: First Insights into the Method European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Dec, 2013 | Pubmed ID: 23764946 Analysis of Immobilized Artificial Membrane Retention Factors for Both Neutral and Ionic Species Journal of Chromatography. A. Jul, 2013 | Pubmed ID: 23726245 Liposomal Encapsulation of a Near-infrared Fluorophore Enhances Fluorescence Quenching and Reliable Whole Body Optical Imaging Upon Activation in Vivo Small (Weinheim an Der Bergstrasse, Germany). Nov, 2013 | Pubmed ID: 23650267 Transfer of a Lipophilic Drug (temoporfin) Between Small Unilamellar Liposomes and Human Plasma Proteins: Influence of Membrane Composition on Vesicle Integrity and Release Characteristics Journal of Liposome Research. Jun, 2013 | Pubmed ID: 23590339 Pharmacokinetics of Temoporfin-loaded Liposome Formulations: Correlation of Liposome and Temoporfin Blood Concentration Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2013 | Pubmed ID: 23313962 Encapsulation of Ferritin, Ribosomes, and Ribo-peptidic Complexes Inside Liposomes: Insights into the Origin of Metabolism Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life. Oct, 2012 | Pubmed ID: 23080007 Degradation Kinetics of an Aspartyl-tripeptide-derived Diketopiperazine Under Forced Conditions Journal of Pharmaceutical Sciences. Nov, 2012 | Pubmed ID: 22899465 Analysis of Liposomes Using Asymmetrical Flow Field-flow Fractionation: Separation Conditions and Drug/lipid Recovery Journal of Separation Science. Aug, 2012 | Pubmed ID: 22865761 Elastic Vesicles for Transdermal Drug Delivery of Hydrophilic Drugs: a Comparison of Important Physicochemical Characteristics of Different Vesicle Types Journal of Biomedical Nanotechnology. Aug, 2012 | Pubmed ID: 22852471 Liposomes in Topical Photodynamic Therapy Expert Opinion on Drug Delivery. Aug, 2012 | Pubmed ID: 22731896 Selective Partitioning of Cholesterol and a Model Drug into Liposomes of Varying Size Chemistry and Physics of Lipids. Jul, 2012 | Pubmed ID: 22534024 Human Skin Permeation of Neutral Species and Ionic Species: Extended Linear Free-energy Relationship Analyses Journal of Pharmaceutical Sciences. Jun, 2012 | Pubmed ID: 22415339 Interfacial Concentrations of Chloride and Bromide in Zwitterionic Micelles with Opposite Dipoles: Experimental Determination by Chemical Trapping and a Theoretical Description Journal of Colloid and Interface Science. Apr, 2012 | Pubmed ID: 22305573 Wheat Germ Agglutinin Modified Liposomes for the Photodynamic Inactivation of Bacteria Photochemistry and Photobiology. May-Jun, 2012 | Pubmed ID: 21834868 Fast High-throughput Screening of Temoporfin-loaded Liposomal Formulations Prepared by Ethanol Injection Method Journal of Liposome Research. Mar, 2012 | Pubmed ID: 21682653 Lecithin-based Novel Cationic Nanocarriers (LeciPlex) I: Fabrication, Characterization and Evaluation Nanomedicine (London, England). Oct, 2011 | Pubmed ID: 22026377 Drug Delivery Strategies for Poorly Water-soluble Drugs: the Industrial Perspective Expert Opinion on Drug Delivery. Nov, 2011 | Pubmed ID: 21895540 Spontaneous Crowding of Ribosomes and Proteins Inside Vesicles: a Possible Mechanism for the Origin of Cell Metabolism Chembiochem : a European Journal of Chemical Biology. Oct, 2011 | Pubmed ID: 21830290 Antimicrobial Peptide-modified Liposomes for Bacteria Targeted Delivery of Temoporfin in Photodynamic Antimicrobial Chemotherapy Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology. Oct, 2011 | Pubmed ID: 21773628 Modeling the Release Kinetics of Poorly Water-soluble Drug Molecules from Liposomal Nanocarriers Journal of Drug Delivery. 2011 | Pubmed ID: 21773045 [Non-viral Gene Transfer Medicinal Products. Therapy with Synthetic Vectors] Pharmazie in Unserer Zeit. May, 2011 | Pubmed ID: 21698610 Assessment of Fluidity of Different Invasomes by Electron Spin Resonance and Differential Scanning Calorimetry International Journal of Pharmaceutics. Jun, 2011 | Pubmed ID: 21527323 Lecithin-based Novel Cationic Nanocarriers (Leciplex) II: Improving Therapeutic Efficacy of Quercetin on Oral Administration Molecular Pharmaceutics. Jun, 2011 | Pubmed ID: 21480639 The Physical State of Lipid Nanoparticles Influences Their Effect on in Vitro Cell Viability European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Sep, 2011 | Pubmed ID: 21458564 Linear Free Energy Relationship Analysis of Retention Factors in Cerasome Electrokinetic Chromatography Intended for Predicting Drug Skin Permeation Journal of Pharmaceutical Sciences. Aug, 2011 | Pubmed ID: 21455982 Skin Penetration and Deposition of Carboxyfluorescein and Temoporfin from Different Lipid Vesicular Systems: In Vitro Study with Finite and Infinite Dosage Application International Journal of Pharmaceutics. Apr, 2011 | Pubmed ID: 21316430 Lipophilicity and Its Relationship with Passive Drug Permeation Pharmaceutical Research. May, 2011 | Pubmed ID: 21052797 Cellular Uptake and Degradation Behaviour of Biodegradable Poly(ethylene Glycol-graft-methyl Methacrylate) Nanoparticles Crosslinked with Dimethacryloyl Hydroxylamine International Journal of Pharmaceutics. Jan, 2011 | Pubmed ID: 20969936 Transfer Mechanism of Temoporfin Between Liposomal Membranes Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2011 | Pubmed ID: 20888878 Polymersomes Containing Iron Sulfide (FeS) As Primordial Cell Model : for the Investigation of Energy Providing Redox Reactions Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life. Apr, 2011 | Pubmed ID: 20697814 Skin Delivery of Ferulic Acid from Different Vesicular Systems Journal of Biomedical Nanotechnology. Oct, 2010 | Pubmed ID: 21329050 DHPC Strongly Affects the Structure and Oligomerization Propensity of Alzheimer's Aβ(1-40) Peptide Journal of Molecular Biology. Nov, 2010 | Pubmed ID: 20851128 Spontaneous Protein Crowding in Liposomes: a New Vista for the Origin of Cellular Metabolism Chembiochem : a European Journal of Chemical Biology. Sep, 2010 | Pubmed ID: 20806308 Efficacy of Temoporfin-loaded Invasomes in the Photodynamic Therapy in Human Epidermoid and Colorectal Tumour Cell Lines Journal of Photochemistry and Photobiology. B, Biology. Dec, 2010 | Pubmed ID: 20797872 Kinetics of Aspartic Acid Isomerization and Enantiomerization in Model Aspartyl Tripeptides Under Forced Conditions Journal of Pharmaceutical Sciences. Oct, 2010 | Pubmed ID: 20737625 Temoporfin-loaded Liposomes: Physicochemical Characterization European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jul, 2010 | Pubmed ID: 20412853 Flow Cytometry As a New Approach to Investigate Drug Transfer Between Lipid Particles Molecular Pharmaceutics. Apr, 2010 | Pubmed ID: 20063898 Utilization of Liposomes for Studying Drug Transfer and Uptake Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20013385 Micro-structured Smart Hydrogels with Enhanced Protein Loading and Release Efficiency Acta Biomaterialia. Apr, 2010 | Pubmed ID: 19913647 Surface Charged Temoporfin-loaded Flexible Vesicles: in Vitro Skin Penetration Studies and Stability International Journal of Pharmaceutics. Jan, 2010 | Pubmed ID: 19819321 Stability Evaluation of Temoporfin-loaded Liposomal Gels for Topical Application Journal of Liposome Research. Mar, 2010 | Pubmed ID: 19558347 Preservation of Liquid Drug Preparations for Oral Administration Journal of Pharmaceutical Sciences. Jan, 2010 | Pubmed ID: 19499567 Supercooled Smectic Nanoparticles: Influence of the Matrix Composition and in Vitro Cytotoxicity European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Oct, 2009 | Pubmed ID: 19664705 Development of Liposomes Containing Ethanol for Skin Delivery of Temoporfin: Characterization and in Vitro Penetration Studies Colloids and Surfaces. B, Biointerfaces. Nov, 2009 | Pubmed ID: 19651496 Temoporfin-loaded Liposomal Gels: Viscoelastic Properties and in Vitro Skin Penetration International Journal of Pharmaceutics. May, 2009 | Pubmed ID: 19429291 Development of Different Temoporfin-loaded Invasomes-novel Nanocarriers of Temoporfin: Characterization, Stability and in Vitro Skin Penetration Studies Colloids and Surfaces. B, Biointerfaces. May, 2009 | Pubmed ID: 19188048 Efficiency of Cytoplasmic Delivery by Non-cationic Liposomes to Cells in Vitro: a Confocal Laser Scanning Microscopy Study Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB). Jun, 2009 | Pubmed ID: 18590977 Lipophilicity Measurement of Drugs by Reversed Phase HPLC over Wide PH Range Using an Alkaline-resistant Silica-based Stationary Phase, XBridge Shield RP(18) Chemical & Pharmaceutical Bulletin. Oct, 2008 | Pubmed ID: 18827381 Fluorescent Liposomes As Contrast Agents for in Vivo Optical Imaging of Edemas in Mice Small (Weinheim an Der Bergstrasse, Germany). Aug, 2008 | Pubmed ID: 18666163 Topical Application of Temoporfin-loaded Invasomes for Photodynamic Therapy of Subcutaneously Implanted Tumours in Mice: a Pilot Study Journal of Photochemistry and Photobiology. B, Biology. Apr, 2008 | Pubmed ID: 18316200 Permeability Changes in Response to NONOate and NONOate Prodrug Derived Nitric Oxide in a Blood-brain Barrier Model Formed by Primary Porcine Endothelial Cells Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. May, 2008 | Pubmed ID: 18284923 Temoporfin-loaded Invasomes: Development, Characterization and in Vitro Skin Penetration Studies Journal of Controlled Release : Official Journal of the Controlled Release Society. Apr, 2008 | Pubmed ID: 18281119 A Novel Gene Delivery System for Stable Transfection of Thiopurine-S-methyltransferase Gene in Versatile Cell Types European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. May, 2008 | Pubmed ID: 17988843 Interaction of Lipid Nanoparticles with Human Epidermis and an Organotypic Cell Culture Model International Journal of Pharmaceutics. Apr, 2008 | Pubmed ID: 17920216 Using a Modified Shepards Method for Optimization of a Nanoparticulate Cyclosporine a Formulation Prepared by a Static Mixer Technique Journal of Pharmaceutical Sciences. Feb, 2008 | Pubmed ID: 17853428 Drug Delivery Strategies for Poorly Water-soluble Drugs Expert Opinion on Drug Delivery. Jul, 2007 | Pubmed ID: 17683253 Physicochemical Characterization of Solid Dispersions of Three Antiepileptic Drugs Prepared by Solvent Evaporation Method The Journal of Pharmacy and Pharmacology. May, 2007 | Pubmed ID: 17524229 In Vitro Characterization of Binding and Stability of Single-chain Fv Ni-NTA-liposomes Journal of Drug Targeting. Sep, 2006 | Pubmed ID: 17050123 Lipophilic Drug Transfer Between Liposomal and Biological Membranes: What Does It Mean for Parenteral and Oral Drug Delivery? Journal of Liposome Research. 2006 | Pubmed ID: 16952882 Adaptive Neuro-fuzzy Modeling of Poorly Soluble Drug Formulations Pharmaceutical Research. Jun, 2006 | Pubmed ID: 16715373 Electrostatic Model for Mixed Cationic-zwitterionic Lipid Bilayers Langmuir : the ACS Journal of Surfaces and Colloids. May, 2006 | Pubmed ID: 16700604 Stearylated Octaarginine and Artificial Virus-like Particles for Transfection of SiRNA into Primary Rat Neurons RNA (New York, N.Y.). Jul, 2006 | Pubmed ID: 16699166 Generation of Immunoliposomes Using Recombinant Single-chain Fv Fragments Bound to Ni-NTA-liposomes Journal of Drug Targeting. Aug, 2005 | Pubmed ID: 16308208 Transfer of Lipophilic Drugs Between Liposomal Membranes and Biological Interfaces: Consequences for Drug Delivery European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Nov, 2005 | Pubmed ID: 16112849 Novel Lipid Nanotubes in Dispersions of DMPC Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. Aug, 2004 | Pubmed ID: 15446752 Efficient Gene Delivery with Serum into Human Cancer Cells Using Targeted Anionic Liposomes Journal of Drug Targeting. Jan, 2004 | Pubmed ID: 15203907 Encapsulation of Gadobutrol in AVE-based Liposomal Carriers for MR Detectability Magnetic Resonance Imaging. May, 2004 | Pubmed ID: 15120167 Sustained-release Injectables Formed in Situ and Their Potential Use for Veterinary Products Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2002 | Pubmed ID: 12480306 Interactions of Cyclosporines with Lipid Membranes As Studied by Solid-state Nuclear Magnetic Resonance Spectroscopy and High-sensitivity Titration Calorimetry Journal of Pharmaceutical Sciences. Mar, 2002 | Pubmed ID: 11920770 Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for In Vivo Optical Imaging Felista L. Tansi*1, Ronny Rüger*2, Markus Rabenhold2, Frank Steiniger3, Alfred Fahr2, Ingrid Hilger1 1Experimental Radiology, Institute of Diagnostic and Interventional Radiology I, Jena University Hospital, 2Department of Pharmaceutical Technology, Friedrich-Schiller-University Jena, 3Center for Electron Microscopy, Jena University Hospital JoVE 52136 Biotechnik
Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for In Vivo Optical Imaging Felista L. Tansi*1, Ronny Rüger*2, Markus Rabenhold2, Frank Steiniger3, Alfred Fahr2, Ingrid Hilger1 1Experimental Radiology, Institute of Diagnostic and Interventional Radiology I, Jena University Hospital, 2Department of Pharmaceutical Technology, Friedrich-Schiller-University Jena, 3Center for Electron Microscopy, Jena University Hospital JoVE 52136 Biotechnik