Hans Werner Müller Molecular Neurobiology Laboratory, Department of Neurology Heinrich-Heine-University Medical Center Biography Publications Institution JoVE Articles Hans Werner Müller has not added a biography. If you are Hans Werner Müller and would like to personalize this page please email our Author Liaison for assistance. Publications Erratum To: Growth/differentiation Factor-15 and Its Role in Peripheral Nervous System Lesion and Regeneration Cell and Tissue Research. Oct, 2015 | Pubmed ID: 26224541 Pharmacological Suppression of CNS Scarring by Deferoxamine Reduces Lesion Volume and Increases Regeneration in an In Vitro Model for Astroglial-Fibrotic Scarring and in Rat Spinal Cord Injury In Vivo PloS One. 2015 | Pubmed ID: 26222542 Characterization of Regenerative Phenotype of Unrestricted Somatic Stem Cells (USSC) from Human Umbilical Cord Blood (hUCB) by Functional Secretome Analysis Molecular & Cellular Proteomics : MCP. Oct, 2015 | Pubmed ID: 26183719 Growth/differentiation Factor-15 and Its Role in Peripheral Nervous System Lesion and Regeneration Cell and Tissue Research. Nov, 2015 | Pubmed ID: 26077927 AAV-mediated Expression of BAG1 and ROCK2-shRNA Promote Neuronal Survival and Axonal Sprouting in a Rat Model of Rubrospinal Tract Injury Journal of Neurochemistry. Jul, 2015 | Pubmed ID: 25807858 Neural ECM Mimetics Progress in Brain Research. 2014 | Pubmed ID: 25410366 Spinal Cord Injury - There is Not Just One Way of Treating It F1000prime Reports. 2014 | Pubmed ID: 25343041 Long-lasting Significant Functional Improvement in Chronic Severe Spinal Cord Injury Following Scar Resection and Polyethylene Glycol Implantation Neurobiology of Disease. Jul, 2014 | Pubmed ID: 24713436 Age-dependent Modulation of Cortical Transcriptomes in Spinal Cord Injury and Repair PloS One. 2012 | Pubmed ID: 23236355 Concise Review: the Potential of Stromal Cell-derived Factor 1 and Its Receptors to Promote Stem Cell Functions in Spinal Cord Repair Stem Cells Translational Medicine. Oct, 2012 | Pubmed ID: 23197665 Defeating Inhibition of Regeneration by Scar and Myelin Components Handbook of Clinical Neurology. 2012 | Pubmed ID: 23098733 Chemokines in CNS Injury and Repair Cell and Tissue Research. Jul, 2012 | Pubmed ID: 22700007 SDF-1/CXCL12: Its Role in Spinal Cord Injury The International Journal of Biochemistry & Cell Biology. Mar, 2012 | Pubmed ID: 22172378 Significant Clinical, Neuropathological and Behavioural Recovery from Acute Spinal Cord Trauma by Transplantation of a Well-defined Somatic Stem Cell from Human Umbilical Cord Blood Brain : a Journal of Neurology. Feb, 2012 | Pubmed ID: 21903726 Bioartificial Reconstruction of Peripheral Nerves Using the Rat Median Nerve Model Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft. Jul, 2011 | Pubmed ID: 21489766 MicroRNAs MiR-17, MiR-20a, and MiR-106b Act in Concert to Modulate E2F Activity on Cell Cycle Arrest During Neuronal Lineage Differentiation of USSC PloS One. 2011 | Pubmed ID: 21283765 Network-like Impact of MicroRNAs on Neuronal Lineage Differentiation of Unrestricted Somatic Stem Cells from Human Cord Blood Stem Cells and Development. Aug, 2011 | Pubmed ID: 21067317 Assessment of Gadolinium Leakage into Traumatic Spinal Cord Lesion Using Magnet Resonance Imaging Spine. Dec, 2010 | Pubmed ID: 21116216 Enhanced Regenerative Axon Growth of Multiple Fibre Populations in Traumatic Spinal Cord Injury Following Scar-suppressing Treatment The European Journal of Neuroscience. Oct, 2009 | Pubmed ID: 19817844 Pharmacological Modification of the Extracellular Matrix to Promote Regeneration of the Injured Brain and Spinal Cord Progress in Brain Research. 2009 | Pubmed ID: 19660662 Glucose-dependent Insulinotropic Polypeptide (GIP) and Its Receptor (GIPR): Cellular Localization, Lesion-affected Expression, and Impaired Regenerative Axonal Growth Journal of Neuroscience Research. Jun, 2009 | Pubmed ID: 19170165 The Alpha-chemokine CXCL14 is Up-regulated in the Sciatic Nerve of a Mouse Model of Charcot-Marie-Tooth Disease Type 1A and Alters Myelin Gene Expression in Cultured Schwann Cells Neurobiology of Disease. Mar, 2009 | Pubmed ID: 19111616 SDF-1 Stimulates Neurite Growth on Inhibitory CNS Myelin Molecular and Cellular Neurosciences. Feb, 2009 | Pubmed ID: 19084600 Unrestricted Somatic Stem Cells from Human Umbilical Cord Blood Can Be Differentiated into Neurons with a Dopaminergic Phenotype Stem Cells and Development. Apr, 2008 | Pubmed ID: 18447638 Long Nerve Gaps Limit the Regenerative Potential of Bioartificial Nerve Conduits Filled with Schwann Cells Restorative Neurology and Neuroscience. 2007 | Pubmed ID: 17726272 The Collagenous Wound Healing Scar in the Injured Central Nervous System Inhibits Axonal Regeneration Advances in Experimental Medicine and Biology. 2006 | Pubmed ID: 16955711 Collagen Matrix in Spinal Cord Injury Journal of Neurotrauma. Mar-Apr, 2006 | Pubmed ID: 16629627 Cross-chest Median Nerve Transfer: a New Model for the Evaluation of Nerve Regeneration Across a 40 Mm Gap in the Rat Journal of Neuroscience Methods. Sep, 2006 | Pubmed ID: 16621004 Gene Expression Profiling Reveals That Peripheral Nerve Regeneration is a Consequence of Both Novel Injury-dependent and Reactivated Developmental Processes Journal of Neurochemistry. Mar, 2006 | Pubmed ID: 16478531 Nerve Regeneration Across a 2-cm Gap in the Rat Median Nerve Using a Resorbable Nerve Conduit Filled with Schwann Cells Journal of Neurosurgery. Dec, 2005 | Pubmed ID: 16381194 Suppression of Fibrous Scarring in Spinal Cord Injury of Rat Promotes Long-distance Regeneration of Corticospinal Tract Axons, Rescue of Primary Motoneurons in Somatosensory Cortex and Significant Functional Recovery The European Journal of Neuroscience. Dec, 2005 | Pubmed ID: 16367771 Evidence for Macrophage-mediated Myelin Disruption in an Animal Model for Charcot-Marie-Tooth Neuropathy Type 1A Journal of Neuroscience Research. Sep, 2005 | Pubmed ID: 16041800 Peripheral Myelin Protein 22 KDa and Protein Zero: Domain Specific Trans-interactions Molecular and Cellular Neurosciences. Dec, 2004 | Pubmed ID: 15555916 Identification and Characterization of ZFP-57, a Novel Zinc Finger Transcription Factor in the Mammalian Peripheral Nervous System The Journal of Biological Chemistry. Jun, 2004 | Pubmed ID: 15070898 Gene Expression Profiling Reveals Multiple Novel Intrinsic and Extrinsic Factors Associated with Axonal Regeneration Failure The European Journal of Neuroscience. Jan, 2004 | Pubmed ID: 14750961 Effects of Chronic Intraventricular Infusion of Heparin Glycosaminoglycan on Learning and Brain Acetylcholine Parameters in Aged Rats Behavioural Brain Research. Dec, 2003 | Pubmed ID: 14659577 Combinatorial Code of Growth Factors and Neuropeptides Define Neuroendocrine Differentiation in PC12 Cells Experimental Neurology. Nov, 2003 | Pubmed ID: 14637105 Cyclic AMP and Tumor Necrosis Factor-alpha Regulate CXCR4 Gene Expression in Schwann Cells Molecular and Cellular Neurosciences. Sep, 2003 | Pubmed ID: 14550764 Proteolipid Plasmolipin: Localization in Polarized Cells, Regulated Expression and Lipid Raft Association in CNS and PNS Myelin Journal of Neurochemistry. Jul, 2003 | Pubmed ID: 12871592 Rat Schwann Cells in Bioresorbable Nerve Guides to Promote and Accelerate Axonal Regeneration Brain Research. Feb, 2003 | Pubmed ID: 12560139 Dynamic Changes in Gene Expression Profiles Following Axotomy of Projection Fibres in the Mammalian CNS Molecular and Cellular Neurosciences. Nov, 2002 | Pubmed ID: 12498784 Ammonia-induced Heme Oxygenase-1 Expression in Cultured Rat Astrocytes and Rat Brain in Vivo Glia. Dec, 2002 | Pubmed ID: 12420312 Functional CXCR4 Receptor Development Parallels Sensitivity to HIV-1 Gp120 in Cultured Rat Astroglial Cells but Not in Cultured Rat Cortical Neurons Journal of Neurovirology. Oct, 2002 | Pubmed ID: 12402167 Mammalian Achaete Scute Homolog 2 is Expressed in the Adult Sciatic Nerve and Regulates the Expression of Krox24, Mob-1, CXCR4, and P57kip2 in Schwann Cells The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2002 | Pubmed ID: 12196582 A Monoclonal Antibody Against a Neuron-specific 65-kDa Protein with Laminar Expression in the Developing Cerebral Cortex Histochemistry and Cell Biology. Apr, 2002 | Pubmed ID: 11976904 Nitric Oxide Reacts with the Single-electron Reduced Active Site of Cytochrome C Oxidase The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11950842 Osteopontin: a Novel Axon-regulated Schwann Cell Gene Journal of Neuroscience Research. Jan, 2002 | Pubmed ID: 11782959 Scar Modulation in Subacute and Chronic CNS Lesions: Effects on Axonal Regeneration Restorative Neurology and Neuroscience. 1999 | Pubmed ID: 12671239 Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion Nicole Brazda*1, Veronica Estrada*1, Christian Voss2,3, Klaus Seide3, Hoc Khiem Trieu2, Hans Werner Müller1 1Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University Medical Center, 2Institute of Microsystems Technology, Hamburg University of Technology, 3Biomechanical Laboratory, BG Trauma Center Hamburg JoVE 53331 Neurowissenschaften
Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion Nicole Brazda*1, Veronica Estrada*1, Christian Voss2,3, Klaus Seide3, Hoc Khiem Trieu2, Hans Werner Müller1 1Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University Medical Center, 2Institute of Microsystems Technology, Hamburg University of Technology, 3Biomechanical Laboratory, BG Trauma Center Hamburg JoVE 53331 Neurowissenschaften