Hubert Schorle Department of Developmental Pathology Institute of Pathology, University of Bonn Medical School Biography Publications Institution JoVE Articles Hubert Schorle has not added a biography. If you are Hubert Schorle and would like to personalize this page please email our Author Liaison for assistance. Publications SOX2 is Essential for in Vivo Reprogramming of Seminoma-like TCam-2 Cells to an Embryonal Carcinoma-like Fate Oncotarget. Jun, 2016 | Pubmed ID: 27283990 Tpbpa-Cre-mediated Deletion of TFAP2C Leads to Deregulation of Cdkn1a, Akt1 and the ERK Pathway, Causing Placental Growth Arrest Development (Cambridge, England). Mar, 2016 | Pubmed ID: 26811378 Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts Cell Stem Cell. Nov, 2015 | Pubmed ID: 26412560 BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency Via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma PLoS Genetics. Jul, 2015 | Pubmed ID: 26226633 Reduced Gene Dosage of Tfap2c Impairs Trophoblast Lineage Differentiation and Alters Maternal Blood Spaces in the Mouse Placenta Biology of Reproduction. Aug, 2015 | Pubmed ID: 26063869 Co-existence of Intact Stemness and Priming of Neural Differentiation Programs in MES Cells Lacking Trim71 Scientific Reports. 2015 | Pubmed ID: 26057209 Injury-induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics Neuron. May, 2015 | Pubmed ID: 25937169 Reference Gene Validation for RT-qPCR, a Note on Different Available Software Packages PloS One. 2015 | Pubmed ID: 25825906 Derivation and Maintenance of Murine Trophoblast Stem Cells Under Defined Conditions Stem Cell Reports. Feb, 2014 | Pubmed ID: 24527396 Analysis of TET Expression/activity and 5mC Oxidation During Normal and Malignant Germ Cell Development PloS One. 2013 | Pubmed ID: 24386123 Transcription Factor TFAP2C Regulates Major Programs Required for Murine Fetal Germ Cell Maintenance and Haploinsufficiency Predisposes to Teratomas in Male Mice PloS One. 2013 | Pubmed ID: 23967156 Fetuin-B, a Liver-derived Plasma Protein is Essential for Fertilization Developmental Cell. Apr, 2013 | Pubmed ID: 23562279 Valproic Acid Confers Functional Pluripotency to Human Amniotic Fluid Stem Cells in a Transgene-free Approach Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2012 | Pubmed ID: 22760542 Connexin 31 (GJB3) Deficiency in Mouse Trophoblast Stem Cells Alters Giant Cell Differentiation and Leads to Loss of Oxygen Sensing Biology of Reproduction. Aug, 2012 | Pubmed ID: 22623621 The Role of Transcription Factor Tcfap2c/TFAP2C in Trophectoderm Development Reproductive Biomedicine Online. Jul, 2012 | Pubmed ID: 22560121 Establishment of a Versatile Seminoma Model Indicates Cellular Plasticity of Germ Cell Tumor Cells Genes, Chromosomes & Cancer. Jul, 2012 | Pubmed ID: 22489004 血小板衍生生长因子信号控制依赖年龄的扩散在胰腺 β 细胞中。 Nature. Oct, 2011 | Pubmed ID: 21993628 精原细胞瘤细胞系 TCam 2 HDAC 抑制剂 Depsipeptide 对敏感但容忍其他各类化疗药物和 NANOG 表达的损失。 Genes, Chromosomes & Cancer. Dec, 2011 | Pubmed ID: 21987446 喂哺乳母 HC11 细胞分化不被伴随 AP 2 转录因子基因的下调。 BMC Research Notes. 2011 | Pubmed ID: 21906301 Tcfap2c/AP-2gamma 的转基因肿瘤导致肝衰竭和肠道发育不良。 PloS One. 2011 | Pubmed ID: 21779369 沿袭转换为多能干细胞小鼠胚外滋养细胞干细胞。 Molecular and Cellular Biology. Apr, 2011 | Pubmed ID: 21300784 NANOG 启动子甲基化和表达相关性正常和恶性胚芽细胞发育过程。 Epigenetics : Official Journal of the DNA Methylation Society. Jan, 2011 | Pubmed ID: 20930529 激活蛋白-2 转录因子的干扰导致诱导细胞凋亡和增加在化疗和放射-敏在乳腺癌细胞中。 BMC Cancer. 2010 | Pubmed ID: 20459791 转录因子 TCFAP2C/AP-2gamma 与 CDX2 保持 Trophectoderm 形成合作。 Molecular and Cellular Biology. Jul, 2010 | Pubmed ID: 20404091 转录因子 AP-2gamma/TFAP2C 的损失损害小鼠乳腺分支形态发生。 Developmental Dynamics : an Official Publication of the American Association of Anatomists. Mar, 2010 | Pubmed ID: 20131354 AP 2 γ/TCFAP2C 在小鼠胚胎生殖细胞维修中的关键功能。 Biology of Reproduction. Jan, 2010 | Pubmed ID: 19776388 AP2gamma 规定了基祖命运在发展中国家皮质中的特定区域和层的方式。 Nature Neuroscience. Oct, 2009 | Pubmed ID: 19749747 AP 2alpha 规定了通过一项涉及 Axl 受体酪氨酸激酶的特定遗传方案 GN 11 神经元的迁移。 BMC Biology. 2009 | Pubmed ID: 19463168 缝隙连接蛋白 43 介导的缝隙连接肢芽间质耦合损失导致小鼠 Morphogens 表达改变。 Human Molecular Genetics. Aug, 2009 | Pubmed ID: 19439426 血小板衍生生长因子受体 α 活化突变会导致胚胎致死致畸形的血管系统。 Developmental Dynamics : an Official Publication of the American Association of Anatomists. May, 2009 | Pubmed ID: 19334281 土著肝肿瘤诱导全身 T 细胞耐受与 T 细胞受体向下-调制相关联。 Hepatology (Baltimore, Md.). Feb, 2009 | Pubmed ID: 19105207 成骨细胞信号转导的持续的血小板衍生的生长因子受体 α 由 Overactivating 磷脂酶 C-γ 途径导致颅缝早闭。 Molecular and Cellular Biology. Feb, 2009 | Pubmed ID: 19047372 BLIMP1/PRMT5 和并发组蛋白 H2A /h4 精氨酸 3 Dimethylation 在胎胚细胞、 独联体/IGCNU 和生殖细胞肿瘤中的表达。 BMC Developmental Biology. 2008 | Pubmed ID: 18992153 喂哺乳母 HC11 细胞分化不被伴随 AP 2 转录因子基因的下调。 BMC Research Notes. 2008 | Pubmed ID: 18710545 基因表达谱标识生殖细胞肿瘤的新的生物标志物。 Anticancer Research. Sep-Oct, 2007 | Pubmed ID: 17970049 增强的纯化后到小鼠胚胎干细胞转导细胞 Permeant Cre 和生殖传播。 Genesis (New York, N.Y. : 2000). Aug, 2007 | Pubmed ID: 17661398 特定的泛素蛋白酶 8 受体酪氨酸激酶稳定性和吞贩运体内的重要作用。 Molecular and Cellular Biology. Jul, 2007 | Pubmed ID: 17452457 只有 LIM 蛋白 Fhl2 中的缺陷损害皮肤伤口愈合。 The Journal of Cell Biology. Apr, 2007 | Pubmed ID: 17420295 建立和控制的分化的使用条件转基因技术的神经嵴干细胞系。 Differentiation; Research in Biological Diversity. Sep, 2007 | Pubmed ID: 17381545 人类胎儿男性性腺成熟胚细胞标记物的空间表达: 免疫组织化学研究。 Human Reproduction (Oxford, England). Feb, 2006 | Pubmed ID: 16210381 AP 2 家庭的转录因子。 Genome Biology. 2005 | Pubmed ID: 16420676 葡萄糖神经酰胺合成酶在大脑中的特定单元格的删除会导致严重的神经缺陷,出生后。 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16109770 故宫 ALK 的转基因小鼠发展非霍奇金淋巴瘤。 Anticancer Research. Sep-Oct, 2005 | Pubmed ID: 16101126 在隐性的常染色体显性多囊肾病疾病 (ARPKD) 囊性胆明志小鼠模型。 Hepatology (Baltimore, Md.). May, 2005 | Pubmed ID: 15830394 AP 2gamma ErbB-2 致乳腺肿瘤发生的双重作用。 Breast Cancer Research and Treatment. Apr, 2005 | Pubmed ID: 15830141 转录因子 AP-2gamma、 Gonocytes 和 Seminomatous 的生殖细胞肿瘤的新标记。 International Journal of Cancer. Journal International Du Cancer. Jun, 2005 | Pubmed ID: 15700319 不同的空间表达模式的 AP 2alpha 和 AP 2gamma 在非肿瘤性人类乳腺癌和乳腺癌。 Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Mar, 2005 | Pubmed ID: 15467710 朝着夹层 AP-1 (激活蛋白 1) 家庭的复杂性。 Advances in Experimental Medicine and Biology. 2004 | Pubmed ID: 15503467 通过结合 Cre/loxp 序列重组重组和三苯氧胺介导活化细胞 C-myc 原癌基因的特定于类型的条件调节。 Genesis (New York, N.Y. : 2000). Mar, 2004 | Pubmed ID: 15048812 小鼠肝脏中的饥饿反应表明强相关性与延长生命跨度的进程。 Physiological Genomics. Apr, 2004 | Pubmed ID: 14762175 AP 2gamma 转录因子刺激细胞增殖和凋亡和损害转基因模型中的分化。 Molecular Cancer Research : MCR. Oct, 2003 | Pubmed ID: 14573793 300 芯片和 CBP 乙酰基转移酶在成肌的微分作用: 上游 300 芯片 MyoD 和 Myf5 的行为。 The EMBO Journal. Oct, 2003 | Pubmed ID: 14517256 克隆、 表达及表征的小鼠 Efemp1,在部门任职蜂窝视网膜色素变性的突变基因。 Gene Expression Patterns : GEP. Aug, 2003 | Pubmed ID: 12915309 Krüppel 样因子 4 (Klf4) 转录因子 AP 2alpha 在小鼠 Mid-embryogenesis 目标的动态表达。 The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology. Aug, 2003 | Pubmed ID: 12845703 终端缺乏转录因子 AP 2 β 小鼠的肾功能衰竭。 Laboratory Investigation; a Journal of Technical Methods and Pathology. Apr, 2003 | Pubmed ID: 12695560 基因突变的 SBF2,编码在夏科-玛丽-牙病变类型 4B2/11 P 15 Myotubularin 家庭新成员。 Human Molecular Genetics. Feb, 2003 | Pubmed ID: 12554688 Exencephaly 在动物 AP 2alpha 突变杂合性的一个子集。 Teratology. May, 2002 | Pubmed ID: 11967920 转录因子的基因 AP 2 γ 早期小鼠发展的必要条件。 Molecular and Cellular Biology. May, 2002 | Pubmed ID: 11940672 有条件的转录因子 AP 2gamma 通过使用 Cre/loxp 序列重组重组系统的失活。 Genesis (New York, N.Y. : 2000). Feb, 2002 | Pubmed ID: 11857798 消减基因表达屏幕表明转录因子 AP 2 α 的增殖和分化的控制中的作用。 The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11741941 协议小鼠胚胎成纤维细胞直接转化为滋养层干细胞 Caroline Kubaczka1, Hubert Schorle1 1Department of Developmental Pathology, Institute of Pathology, University of Bonn Medical School Entwicklungsbiologie 小鼠神经嵴干细胞的培养鸡胚提取物的生产 Kristian Pajtler*1, Anna Bohrer*1, Jochen Maurer2, Hubert Schorle2, Alexander Schramm1, Angelika Eggert1, Johannes Hubertus Schulte1 1Department of Pediatric Oncology, University Children's Hospital Essen, 2Department of Developmental Pathology, Bonn Medical School, Institute of Pathology JoVE 2380 Neurowissenschaften
协议小鼠胚胎成纤维细胞直接转化为滋养层干细胞 Caroline Kubaczka1, Hubert Schorle1 1Department of Developmental Pathology, Institute of Pathology, University of Bonn Medical School Entwicklungsbiologie
小鼠神经嵴干细胞的培养鸡胚提取物的生产 Kristian Pajtler*1, Anna Bohrer*1, Jochen Maurer2, Hubert Schorle2, Alexander Schramm1, Angelika Eggert1, Johannes Hubertus Schulte1 1Department of Pediatric Oncology, University Children's Hospital Essen, 2Department of Developmental Pathology, Bonn Medical School, Institute of Pathology JoVE 2380 Neurowissenschaften