Nabil G. Seidah Laboratory of Biochemical Neuroendocrinology Institut de Recherches Cliniques de Montréal Biography Publications Institution JoVE Articles Nabil G. Seidah has not added a biography. If you are Nabil G. Seidah and would like to personalize this page please email our Author Liaison for assistance. Publications Processing of Human Toll-like Receptor 7 by Furin-like Proprotein Convertases Is Required for Its Accumulation and Activity in Endosomes Immunity. Oct, 2013 | Pubmed ID: 24138882 Disruption of the Expression of the Proprotein Convertase PC7 Reduces BDNF Production and Affects Learning and Memory in Mice Proceedings of the National Academy of Sciences of the United States of America. Oct, 2013 | Pubmed ID: 24101515 Modulation of Protease Activated Receptor 1 Influences Human Metapneumovirus Disease Severity in a Mouse Model PloS One. 2013 | Pubmed ID: 24015257 PCSK9 Prosegment Chimera As Novel Inhibitors of LDLR Degradation PloS One. 2013 | Pubmed ID: 23951290 Furin is the Primary in Vivo Convertase of Angiopoietin-like 3 and Endothelial Lipase in Hepatocytes The Journal of Biological Chemistry. Sep, 2013 | Pubmed ID: 23918928 The Multifaceted Proprotein Convertases: Their Unique, Redundant, Complementary, and Opposite Functions The Journal of Biological Chemistry. Jul, 2013 | Pubmed ID: 23775089 Regional Distribution and Metabolic Effect of PCSK9 InsLEU and R46L Gene Mutations and ApoE Genotype The Canadian Journal of Cardiology. Aug, 2013 | Pubmed ID: 23743349 Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Can Mediate Degradation of the Low Density Lipoprotein Receptor-related Protein 1 (LRP-1) PloS One. 2013 | Pubmed ID: 23675525 Beyond LDL-C Lowering: Distinct Molecular Sphingolipids Are Good Indicators of Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Deficiency Atherosclerosis. Jun, 2013 | Pubmed ID: 23623011 Viral Envelope Glycoprotein Processing by Proprotein Convertases Antiviral Research. Jul, 2013 | Pubmed ID: 23611717 Evidence from a Randomized Trial That Simvastatin, but Not Ezetimibe, Upregulates Circulating PCSK9 Levels PloS One. 2013 | Pubmed ID: 23544125 Differential Recognition of Old World and New World Arenavirus Envelope Glycoproteins by Subtilisin Kexin Isozyme 1 (SKI-1)/site 1 Protease (S1P) Journal of Virology. Jun, 2013 | Pubmed ID: 23536681 Correspondence Hepatology (Baltimore, Md.). Mar, 2013 | Pubmed ID: 23505014 PCSK9 Plays a Significant Role in Cholesterol Homeostasis and Lipid Transport in Intestinal Epithelial Cells Atherosclerosis. Apr, 2013 | Pubmed ID: 23422832 Implication of the Proprotein Convertases in Iron Homeostasis: Proprotein Convertase 7 Sheds Human Transferrin Receptor 1 and Furin Activates Hepcidin Hepatology (Baltimore, Md.). Jun, 2013 | Pubmed ID: 23390091 The Cytosolic Adaptor AP-1A is Essential for the Trafficking and Function of Niemann-Pick Type C Proteins Traffic (Copenhagen, Denmark). Apr, 2013 | Pubmed ID: 23350547 Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Inhibitors in the Treatment of Hypercholesterolemia and Other Pathologies Current Pharmaceutical Design. 2013 | Pubmed ID: 23317404 Rapid Development of Sensitive, High-throughput, Quantitative and Highly Selective Mass Spectrometric Targeted Immunoassays for Clinically Important Proteins in Human Plasma and Serum Clinical Biochemistry. Apr, 2013 | Pubmed ID: 23313081 Proprotein Convertase Subtilisin/kexin Type 9 Deficiency Reduces Melanoma Metastasis in Liver Neoplasia (New York, N.Y.). Dec, 2012 | Pubmed ID: 23308045 Automated Design of Ligands to Polypharmacological Profiles Nature. Dec, 2012 | Pubmed ID: 23235874 The M2 Module of the Cys-His-rich Domain (CHRD) of PCSK9 is Needed for the Extracellular Low Density Lipoprotein Receptor (LDLR) Degradation Pathway The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 23105118 Opposite Roles of Furin and PC5A in N-Cadherin Processing Neoplasia (New York, N.Y.). Oct, 2012 | Pubmed ID: 23097623 Aortic Calcification: Novel Insights from Familial Hypercholesterolemia and Potential Role for the Low-density Lipoprotein Receptor Atherosclerosis. Sep, 2012 | Pubmed ID: 23040868 Loss- and Gain-of-function PCSK9 Variants: CLEAVAGE SPECIFICITY, DOMINANT NEGATIVE EFFECTS, AND LOW DENSITY LIPOPROTEIN RECEPTOR (LDLR) DEGRADATION The Journal of Biological Chemistry. Sep, 2012 | Pubmed ID: 22875854 Annexin A2 is a Natural Extrahepatic Inhibitor of the PCSK9-induced LDL Receptor Degradation PloS One. 2012 | Pubmed ID: 22848640 Loss of Endothelial Furin Leads to Cardiac Malformation and Early Postnatal Death Molecular and Cellular Biology. Sep, 2012 | Pubmed ID: 22733989 Identification and Characterization of New Gain-of-function Mutations in the PCSK9 Gene Responsible for Autosomal Dominant Hypercholesterolemia Atherosclerosis. Aug, 2012 | Pubmed ID: 22683120 The Biology and Therapeutic Targeting of the Proprotein Convertases Nature Reviews. Drug Discovery. May, 2012 | Pubmed ID: 22679642 SKI-1/S1P Inhibition: a Promising Surrogate to Statins to Block Hepatitis C Virus Replication Antiviral Research. Aug, 2012 | Pubmed ID: 22626636 Disruption of Proprotein Convertase 1/3 (PC1/3) Expression in Mice Causes Innate Immune Defects and Uncontrolled Cytokine Secretion The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22396549 Molecular Characterization of the Processing of Arenavirus Envelope Glycoprotein Precursors by Subtilisin Kexin Isozyme-1/site-1 Protease Journal of Virology. May, 2012 | Pubmed ID: 22357276 SKI-1 and Furin Generate Multiple RGMa Fragments That Regulate Axonal Growth Developmental Cell. Feb, 2012 | Pubmed ID: 22340500 5-thiomannosides Block the Biosynthesis of Dolichol-linked Oligosaccharides and Mimic Class I Congenital Disorders of Glycosylation Chembiochem : a European Journal of Chemical Biology. Feb, 2012 | Pubmed ID: 22262650 Gene Inactivation of Proprotein Convertase Subtilisin/kexin Type 9 Reduces Atherosclerosis in Mice Circulation. Feb, 2012 | Pubmed ID: 22261195 Rosuvastatin, Proprotein Convertase Subtilisin/kexin Type 9 Concentrations, and LDL Cholesterol Response: the JUPITER Trial Clinical Chemistry. Jan, 2012 | Pubmed ID: 22065156 Effect of the Mediterranean Diet with and Without Weight Loss on Surrogate Markers of Cholesterol Homeostasis in Men with the Metabolic Syndrome The British Journal of Nutrition. Mar, 2012 | Pubmed ID: 21787450 The LDLR Deficient Mouse As a Model for Aortic Calcification and Quantification by Micro-computed Tomography Atherosclerosis. Dec, 2011 | Pubmed ID: 22051553 A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy Journal of Aging Research. 2011 | Pubmed ID: 21969914 Novel Loss-of-function PCSK9 Variant is Associated with Low Plasma LDL Cholesterol in a French-Canadian Family and with Impaired Processing and Secretion in Cell Culture Clinical Chemistry. Oct, 2011 | Pubmed ID: 21813713 The Proprotein Convertases, 20 Years Later Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21805237 Latent Transforming Growth Factor Beta-binding Proteins-2 and -3 Inhibit the Proprotein Convertase 5/6A The Journal of Biological Chemistry. Aug, 2011 | Pubmed ID: 21700711 Inactivation of Endothelial Proprotein Convertase 5/6 Decreases Collagen Deposition in the Cardiovascular System: Role of Fibroblast Autophagy Journal of Molecular Medicine (Berlin, Germany). Nov, 2011 | Pubmed ID: 21681612 Arenavirus Envelope Glycoproteins Mimic Autoprocessing Sites of the Cellular Proprotein Convertase Subtilisin Kexin Isozyme-1/site-1 Protease Virology. Aug, 2011 | Pubmed ID: 21612810 Furin is the Major Processing Enzyme of the Cardiac-specific Growth Factor Bone Morphogenetic Protein 10 The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21550985 N-glycosylation Controls Trafficking, Zymogen Activation and Substrate Processing of Proprotein Convertases PC1/3 and Subtilisin Kexin Isozyme-1 Glycobiology. Oct, 2011 | Pubmed ID: 21527438 PCSK9 Reduces the Protein Levels of the LDL Receptor in Mouse Brain During Development and After Ischemic Stroke Journal of Lipid Research. Jul, 2011 | Pubmed ID: 21518694 What Lies Ahead for the Proprotein Convertases? Annals of the New York Academy of Sciences. Mar, 2011 | Pubmed ID: 21388412 Quantitative Proteomic Analysis of PCSK9 Gain of Function in Human Hepatic HuH7 Cells Journal of Proteome Research. Apr, 2011 | Pubmed ID: 21332221 Circulating Proprotein Convertase Subtilisin/kexin 9 (PCSK9) Regulates VLDLR Protein and Triglyceride Accumulation in Visceral Adipose Tissue Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2011 | Pubmed ID: 21273557 Proprotein Convertase PC7 Enhances the Activation of the EGF Receptor Pathway Through Processing of the EGF Precursor The Journal of Biological Chemistry. Mar, 2011 | Pubmed ID: 21209099 In Vivo Evidence That Furin from Hepatocytes Inactivates PCSK9 The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21147780 Atorvastatin Increases Intestinal Expression of NPC1L1 in Hyperlipidemic Men Journal of Lipid Research. Mar, 2011 | Pubmed ID: 21123766 The Proprotein Convertase PC7: Unique Zymogen Activation and Trafficking Pathways The Journal of Biological Chemistry. Jan, 2011 | Pubmed ID: 21075846 Inhibition of Proprotein Convertase SKI-1 Blocks Transcription of Key Extracellular Matrix Genes Regulating Osteoblastic Mineralization The Journal of Biological Chemistry. Jan, 2011 | Pubmed ID: 21075843 Surface Expression of Precursor N-cadherin Promotes Tumor Cell Invasion Neoplasia (New York, N.Y.). Dec, 2010 | Pubmed ID: 21170270 Effects of the Prosegment and PH on the Activity of PCSK9: Evidence for Additional Processing Events The Journal of Biological Chemistry. Dec, 2010 | Pubmed ID: 20937814 Molecular Cloning and Embryonic Expression of Zebrafish PCSK5 Co-orthologues: Functional Assessment During Lateral Line Development Developmental Dynamics : an Official Publication of the American Association of Anatomists. Nov, 2010 | Pubmed ID: 20882679 Zebrafish ProVEGF-C Expression, Proteolytic Processing and Inhibitory Effect of Unprocessed ProVEGF-C During Fin Regeneration PloS One. 2010 | Pubmed ID: 20625388 The Influence of PCSK9 Polymorphisms on Serum Low-density Lipoprotein Cholesterol and Risk of Atherosclerosis Current Atherosclerosis Reports. Sep, 2010 | Pubmed ID: 20623344 A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression in Vitro and in Vivo PloS One. 2010 | Pubmed ID: 20498851 ACAT1 Gene Ablation Increases 24(S)-hydroxycholesterol Content in the Brain and Ameliorates Amyloid Pathology in Mice with AD Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20133765 Intestinal and Hepatic Cholesterol Carriers in Diabetic Psammomys Obesus Endocrinology. Mar, 2010 | Pubmed ID: 20130116 Strong Induction of PCSK9 Gene Expression Through HNF1alpha and SREBP2: Mechanism for the Resistance to LDL-cholesterol Lowering Effect of Statins in Dyslipidemic Hamsters Journal of Lipid Research. Jun, 2010 | Pubmed ID: 20048381 PCSK9-deficient Mice Exhibit Impaired Glucose Tolerance and Pancreatic Islet Abnormalities FEBS Letters. Feb, 2010 | Pubmed ID: 20026049 A New Method for Measurement of Total Plasma PCSK9: Clinical Applications Journal of Lipid Research. Jan, 2010 | Pubmed ID: 19571328 Genetic Variation at the Proprotein Convertase Subtilisin/kexin Type 5 Gene Modulates High-density Lipoprotein Cholesterol Levels Circulation. Cardiovascular Genetics. Oct, 2009 | Pubmed ID: 20031622 The Proprotein Convertase PC5/6 is Protective Against Intestinal Tumorigenesis: in Vivo Mouse Model Molecular Cancer. 2009 | Pubmed ID: 19737405 Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation: Evidence for an Intracellular Route The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19635789 PCSK9 Impedes Hepatitis C Virus Infection in Vitro and Modulates Liver CD81 Expression Hepatology (Baltimore, Md.). Jul, 2009 | Pubmed ID: 19489072 Regulation of the Proprotein Convertase Subtilisin/kexin Type 9 in Intestinal Epithelial Cells American Journal of Physiology. Gastrointestinal and Liver Physiology. Apr, 2009 | Pubmed ID: 19179626 Alzheimer Disease Abeta Production in the Absence of S-palmitoylation-dependent Targeting of BACE1 to Lipid Rafts The Journal of Biological Chemistry. Feb, 2009 | Pubmed ID: 19074428 PCSK9 As a Therapeutic Target of Dyslipidemia Expert Opinion on Therapeutic Targets. Jan, 2009 | Pubmed ID: 19063703 Potential Role of Proprotein Convertase SKI-1 in the Mineralization of Primary Bone Cells, Tissues, Organs. 2009 | Pubmed ID: 18728345 Emerging Viruses: Risk of Pandemic Expert Review of Anti-infective Therapy. Oct, 2008 | Pubmed ID: 18847397 Annexin A2 is a C-terminal PCSK9-binding Protein That Regulates Endogenous Low Density Lipoprotein Receptor Levels The Journal of Biological Chemistry. Nov, 2008 | Pubmed ID: 18799458 Proprotein Convertases As Therapeutic Targets Expert Opinion on Therapeutic Targets. Oct, 2008 | Pubmed ID: 18781827 Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9): Hepatocyte-specific Low-density Lipoprotein Receptor Degradation and Critical Role in Mouse Liver Regeneration Hepatology (Baltimore, Md.). Aug, 2008 | Pubmed ID: 18666258 Inhibition of Chikungunya Virus Infection in Cultured Human Muscle Cells by Furin Inhibitors: Impairment of the Maturation of the E2 Surface Glycoprotein The Journal of Biological Chemistry. Aug, 2008 | Pubmed ID: 18559340 VACTERL/caudal Regression/Currarino Syndrome-like Malformations in Mice with Mutation in the Proprotein Convertase Pcsk5 Genes & Development. Jun, 2008 | Pubmed ID: 18519639 PCSK9 is Phosphorylated by a Golgi Casein Kinase-like Kinase Ex Vivo and Circulates As a Phosphoprotein in Humans The FEBS Journal. Jul, 2008 | Pubmed ID: 18498363 In Vivo Functions of the Proprotein Convertase PC5/6 During Mouse Development: Gdf11 is a Likely Substrate Proceedings of the National Academy of Sciences of the United States of America. Apr, 2008 | Pubmed ID: 18378898 The Activation and Physiological Functions of the Proprotein Convertases The International Journal of Biochemistry & Cell Biology. 2008 | Pubmed ID: 18343183 The H5N1 Influenza Variant Fujian-like Hemagglutinin Selected Following Vaccination Exhibits a Compromised Furin Cleavage : Neurological Consequences of Highly Pathogenic Fujian H5N1 Strains Journal of Molecular Neuroscience : MN. Jul, 2008 | Pubmed ID: 18306058 Selective Inhibition of Proprotein Convertases Represses the Metastatic Potential of Human Colorectal Tumor Cells The Journal of Clinical Investigation. Jan, 2008 | Pubmed ID: 18064302 Cell-surface Processing of Extracellular Human Immunodeficiency Virus Type 1 Vpr by Proprotein Convertases Virology. Mar, 2008 | Pubmed ID: 18061232 The Proprotein Convertase PCSK9 Induces the Degradation of Low Density Lipoprotein Receptor (LDLR) and Its Closest Family Members VLDLR and ApoER2 The Journal of Biological Chemistry. Jan, 2008 | Pubmed ID: 18039658 The Regulated Cell Surface Zymogen Activation of the Proprotein Convertase PC5A Directs the Processing of Its Secretory Substrates The Journal of Biological Chemistry. Jan, 2008 | Pubmed ID: 18039650 Opposing Function of the Proprotein Convertases Furin and PACE4 on Breast Cancer Cells' Malignant Phenotypes: Role of Tissue Inhibitors of Metalloproteinase-1 Cancer Research. Oct, 2007 | Pubmed ID: 17909005 Gene Set Enrichment Analysis Reveals Several Globally Affected Pathways Due to SKI-1/S1P Inhibition in HepG2 Cells DNA and Cell Biology. Nov, 2007 | Pubmed ID: 17867930 Plasma PCSK9 Levels Correlate with Cholesterol in Men but Not in Women Biochemical and Biophysical Research Communications. Sep, 2007 | Pubmed ID: 17645871 PC1/3, PC2 and PC5/6A Are Targeted to Dense Core Secretory Granules by a Common Mechanism The FEBS Journal. Aug, 2007 | Pubmed ID: 17645548 The Proprotein Convertase SKI-1/S1P: Alternate Translation and Subcellular Localization The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17623657 Of PCSK9, Cholesterol Homeostasis and Parasitic Infections: Possible Survival Benefits of Loss-of-function PCSK9 Genetic Polymorphisms Medical Hypotheses. 2007 | Pubmed ID: 17502126 A Targeted Deletion/insertion in the Mouse Pcsk1 Locus is Associated with Homozygous Embryo Preimplantation Lethality, Mutant Allele Preferential Transmission and Heterozygous Female Susceptibility to Dietary Fat Developmental Biology. Jun, 2007 | Pubmed ID: 17490633 The Cellular Trafficking of the Secretory Proprotein Convertase PCSK9 and Its Dependence on the LDLR Traffic (Copenhagen, Denmark). Jun, 2007 | Pubmed ID: 17461796 The Proprotein Convertases Are Potential Targets in the Treatment of Dyslipidemia Journal of Molecular Medicine (Berlin, Germany). Jul, 2007 | Pubmed ID: 17351764 Three Common Alleles of KIR2DL4 (CD158d) Encode Constitutively Expressed, Inducible and Secreted Receptors in NK Cells European Journal of Immunology. Jan, 2007 | Pubmed ID: 17171757 Respiratory Distress and Neonatal Lethality in Mice Lacking Golgi Alpha1,2-mannosidase IB Involved in N-glycan Maturation The Journal of Biological Chemistry. Jan, 2007 | Pubmed ID: 17121831 Proprotein Convertases: Lessons from Knockouts FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Oct, 2006 | Pubmed ID: 17012247 The Proprotein Convertases and Their Implication in Sterol And/or Lipid Metabolism Biological Chemistry. Jul, 2006 | Pubmed ID: 16913836 The Proprotein Convertase (PC) PCSK9 is Inactivated by Furin And/or PC5/6A: Functional Consequences of Natural Mutations and Post-translational Modifications The Journal of Biological Chemistry. Oct, 2006 | Pubmed ID: 16912035 Increased Stress-induced Analgesia in Mice Lacking the Proneuropeptide Convertase PC2 Neuroscience Letters. Oct, 2006 | Pubmed ID: 16905251 Implication of the Proprotein Convertase NARC-1/PCSK9 in the Development of the Nervous System Journal of Neurochemistry. Aug, 2006 | Pubmed ID: 16893422 The Proprotein Convertase SKI-1/S1P. In Vitro Analysis of Lassa Virus Glycoprotein-derived Substrates and Ex Vivo Validation of Irreversible Peptide Inhibitors The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16790437 Unexpected Similarity Between the Cytosolic West Nile Virus NS3 and the Secretory Furin-like Serine Proteinases The Biochemical Journal. Jan, 2006 | Pubmed ID: 16371006 Deletion of the Gene Encoding Proprotein Convertase 5/6 Causes Early Embryonic Lethality in the Mouse Molecular and Cellular Biology. Jan, 2006 | Pubmed ID: 16354705 Evidence for Proprotein Convertase Activity in the Endoplasmic Reticulum/early Golgi FEBS Letters. Oct, 2005 | Pubmed ID: 16213495 Molecular Biology of the Cell. Nov, 2005 | Pubmed ID: 16135528 Chloroquine is a Potent Inhibitor of SARS Coronavirus Infection and Spread Virology Journal. 2005 | Pubmed ID: 16115318 Proprotein Convertases [corrected] Are Responsible for Proteolysis and Inactivation of Endothelial Lipase The Journal of Biological Chemistry. Nov, 2005 | Pubmed ID: 16109723 Dual Regulation of the LDL Receptor--some Clarity and New Questions Cell Metabolism. May, 2005 | Pubmed ID: 16054075 Furin-like Proprotein Convertases Are Central Regulators of the Membrane Type Matrix Metalloproteinase-pro-matrix Metalloproteinase-2 Proteolytic Cascade in Atherosclerosis Circulation. May, 2005 | Pubmed ID: 15911696 Human Carcinoma Cell Growth and Invasiveness is Impaired by the Propeptide of the Ubiquitous Proprotein Convertase Furin Cancer Research. May, 2005 | Pubmed ID: 15899807 Immunohistochemical Localization of Subtilisin/kexin-like Proprotein Convertases in Human Atherosclerosis Virchows Archiv : an International Journal of Pathology. Apr, 2005 | Pubmed ID: 15756593 Wild-type PCSK9 Inhibits LDL Clearance but Does Not Affect ApoB-containing Lipoprotein Production in Mouse and Cultured Cells Journal of Lipid Research. Jun, 2005 | Pubmed ID: 15741654 Beta-amyloid Protein Converting Enzyme 1 and Brain-specific Type II Membrane Protein BRI3: Binding Partners Processed by Furin Journal of Neurochemistry. Jan, 2005 | Pubmed ID: 15606899 Implication of Proprotein Convertases in the Processing and Spread of Severe Acute Respiratory Syndrome Coronavirus Biochemical and Biophysical Research Communications. Jan, 2005 | Pubmed ID: 15596135 The Metabolism of Beta-amyloid Converting Enzyme and Beta-amyloid Precursor Protein Processing Biochemical and Biophysical Research Communications. Dec, 2004 | Pubmed ID: 15522224 Endothelium-restricted Overexpression of Human Endothelin-1 Causes Vascular Remodeling and Endothelial Dysfunction Circulation. Oct, 2004 | Pubmed ID: 15466627 NARC-1/PCSK9 and Its Natural Mutants: Zymogen Cleavage and Effects on the Low Density Lipoprotein (LDL) Receptor and LDL Cholesterol The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15358785 Implications of Proprotein Convertase 5 (PC5) in the Arterial Restenotic Process in a Porcine Model Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology. Sep-Oct, 2004 | Pubmed ID: 15358338 Proprotein Convertases Regulate Insulin-like Growth Factor 1-induced Membrane-type 1 Matrix Metalloproteinase in VSMCs Via Endoproteolytic Activation of the Insulin-like Growth Factor-1 Receptor Biochemical and Biophysical Research Communications. Aug, 2004 | Pubmed ID: 15358140 Regulation of Matrix Metalloproteinase MT1-MMP/MMP-2 in Cardiac Fibroblasts by TGF-beta1 Involves Furin-convertase Cardiovascular Research. Jul, 2004 | Pubmed ID: 15194465 Statins Upregulate PCSK9, the Gene Encoding the Proprotein Convertase Neural Apoptosis-regulated Convertase-1 Implicated in Familial Hypercholesterolemia Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2004 | Pubmed ID: 15178557 Inhibition of Proprotein Convertases Enhances Cell Migration and Metastases Development of Human Colon Carcinoma Cells in a Rat Model The American Journal of Pathology. Jun, 2004 | Pubmed ID: 15161629 Stepwise Posttranslational Processing of Progrowth Hormone-releasing Hormone (proGHRH) Polypeptide by Furin and PC1 Endocrine. Mar-Apr, 2004 | Pubmed ID: 15146101 Development of Protein-based Inhibitors of the Proprotein of Convertase SKI-1/S1P: Processing of SREBP-2, ATF6, and a Viral Glycoprotein The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14970232 Endoproteolytic Activation of Alpha(v) Integrin by Proprotein Convertase PC5 is Required for Vascular Smooth Muscle Cell Adhesion to Vitronectin and Integrin-dependent Signaling Circulation. Feb, 2004 | Pubmed ID: 14970114 Neurotrophin-4, Alone or Heterodimerized with Brain-derived Neurotrophic Factor, is Sorted to the Constitutive Secretory Pathway The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12970359 Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Proteolytic Processing by Subtilase SKI-1 Journal of Virology. Aug, 2003 | Pubmed ID: 12885882 The Secretory Proprotein Convertases Furin, PC5, and PC7 Activate VEGF-C to Induce Tumorigenesis The Journal of Clinical Investigation. Jun, 2003 | Pubmed ID: 12782675 A Serine Protease Inhibitor Prevents Endoplasmic Reticulum Stress-induced Cleavage but Not Transport of the Membrane-bound Transcription Factor ATF6 The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12782636 Mutations in PCSK9 Cause Autosomal Dominant Hypercholesterolemia Nature Genetics. Jun, 2003 | Pubmed ID: 12730697 Processing of Alpha4 Integrin by the Proprotein Convertases: Histidine at Position P6 Regulates Cleavage The Biochemical Journal. Jul, 2003 | Pubmed ID: 12691605 The Proteolytic Processing of Pro-platelet-derived Growth Factor-A at RRKR(86) by Members of the Proprotein Convertase Family is Functionally Correlated to Platelet-derived Growth Factor-A-induced Functions and Tumorigenicity Cancer Research. Apr, 2003 | Pubmed ID: 12670890 Coordinated Regulation and Colocalization of Alphav Integrin and Its Activating Enzyme Proprotein Convertase PC5 in Vivo Histochemistry and Cell Biology. Mar, 2003 | Pubmed ID: 12649739 Proteolytic Processing of Chromogranin A by the Prohormone Convertase PC2 Regulatory Peptides. Mar, 2003 | Pubmed ID: 12609757 The Secretory Proprotein Convertase Neural Apoptosis-regulated Convertase 1 (NARC-1): Liver Regeneration and Neuronal Differentiation Proceedings of the National Academy of Sciences of the United States of America. Feb, 2003 | Pubmed ID: 12552133 The Proprotein Convertase PC5A and a Metalloprotease Are Involved in the Proteolytic Processing of the Neural Adhesion Molecule L1 The Journal of Biological Chemistry. Mar, 2003 | Pubmed ID: 12529374 Down-regulation of Alpha V/beta 3 Integrin Via Misrouting to Lysosomes by Overexpression of a Beta 3Lamp1 Fusion Protein The Biochemical Journal. Mar, 2003 | Pubmed ID: 12444923 Structure-function Analysis of the Prosegment of the Proprotein Convertase PC5A The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12414802 Precursor Convertases in the Secretory Pathway, Cytosol and Extracellular Milieu Essays in Biochemistry. 2002 | Pubmed ID: 12463163 Role of Proprotein Convertases in the Pathogenic Processing of the Amyloidosis-associated Form of Secretory Gelsolin Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. Jun, 2002 | Pubmed ID: 12440480 Altered Processing of the Neurotensin/neuromedin N Precursor in PC2 Knock Down Mice: a Biochemical and Immunohistochemical Study Journal of Neurochemistry. Aug, 2002 | Pubmed ID: 12358783 Characterization of a Repressor Element in the Promoter Region of Proprotein Convertase 2 (PC2) Gene Brain Research. Molecular Brain Research. Jun, 2002 | Pubmed ID: 12191492 Genetic Mapping of the Gene for SKI-1/S1P Protease (locus Symbol Mbtps1) to Mouse Chromosome 8 DNA Sequence : the Journal of DNA Sequencing and Mapping. Apr, 2002 | Pubmed ID: 12180344 The Metalloendopeptidase Nardilysin (NRDc) is Potently Inhibited by Heparin-binding Epidermal Growth Factor-like Growth Factor (HB-EGF) The Biochemical Journal. Oct, 2002 | Pubmed ID: 12095415 Proprotein Convertases in Tumor Progression and Malignancy: Novel Targets in Cancer Therapy The American Journal of Pathology. Jun, 2002 | Pubmed ID: 12057895 A Rapid Fluorometric Assay for the Proteolytic Activity of SKI-1/S1P Based on the Surface Glycoprotein of the Hemorrhagic Fever Lassa Virus FEBS Letters. Mar, 2002 | Pubmed ID: 11943176 Proprotein Convertases Are Important Mediators of the Adipocyte Differentiation of Mouse 3T3-L1 Cells Journal of Cell Science. Mar, 2002 | Pubmed ID: 11884519 Biosynthesis and Cellular Trafficking of the Convertase SKI-1/S1P: Ectodomain Shedding Requires SKI-1 Activity The Journal of Biological Chemistry. Mar, 2002 | Pubmed ID: 11756446 In utero Measurement of Heart Rate in Mouse by Noninvasive M-mode Echocardiography WooJin Kim1, Nabil G. Seidah1, Annik Prat1 1Laboratory of Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal JoVE 50994 Medizin Mouse Model of Intraluminal MCAO: Cerebral Infarct Evaluation by Cresyl Violet Staining Estelle Rousselet1, Jasna Kriz2, Nabil G. Seidah1 1Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, 2CHUQ Research Centre, Laval University JoVE 4038 Medizin
In utero Measurement of Heart Rate in Mouse by Noninvasive M-mode Echocardiography WooJin Kim1, Nabil G. Seidah1, Annik Prat1 1Laboratory of Biochemical Neuroendocrinology, Institut de Recherches Cliniques de Montréal JoVE 50994 Medizin
Mouse Model of Intraluminal MCAO: Cerebral Infarct Evaluation by Cresyl Violet Staining Estelle Rousselet1, Jasna Kriz2, Nabil G. Seidah1 1Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, 2CHUQ Research Centre, Laval University JoVE 4038 Medizin