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1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine,University of California at Los Angeles, 2Crump Institute for Molecular Imaging, David Geffen School of Medicine,University of California at Los Angeles, 3California NanoSystems Institute,University of California at Los Angeles, 4Nuclear Medicine, PET Center, Shanghai Medical Collegea,Fudan University, 5Electronics and Information Engineering, College of Electronics and Information Engineering,Wuhan Textile University
Kapitel
- 00:05Titel
- 01:51Preparation for [18F]SFB Synthesis
- 03:03[18F]SFB Synthesis
- 04:44Preparation of Solid Phase Extraction (SPE)-purified [18F]SFB
- 07:24Representative Results for the Microwave-assisted One-pot Synthesis of [18F]SFB
- 08:10Conclusion
의 손쉬운, 한 냄비 합성 N - succinimidyl - 4 - [<sup> 18</sup> F] fluorobenzoate ([<sup> 18</sup> F] SFB)가 아닌 수성, 3 단계 radiochemical 프로세스를 기반으로 개발되었습니다. 마이크 로파 가열을 사용하여 전체 절차는 30 분, 또는 예비 HPLC에 의해 더욱 정화와 60 분 안에 완료할 수 있습니다. 부패 - 수정 radiochemical 수확량 (RCYs)는 35-5% (n은> 30)되었습니다.
Tags
Microwave-assistedOne-pot SynthesisN-succinimidyl-4-[18F]fluorobenzoate[18F]SFBBiomoleculesPeptidesProteinsAntibodiesEngineered FragmentsTherapeuticsMolecular Imaging AgentsPositron-emitting RadioisotopesCu-64Ga-68F-18Targeted ImagingPhysiological ProcessesPathological ProcessesSynthesisExploration18F-labeled BiomoleculesDirect 18F-labelingOrganic SolventExtreme PHHigh TemperatureRadiolabeled Prosthetic GroupsMethod Of ChoiceBolton-Hunter Type ReagentPrimary Amino GroupsIn Vivo StabilityRadiolabeling YieldPET Tracers
