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A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
 

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Article DOI: 10.3791/50232-v • 10:03 min • February 28th, 2013
February 28th, 2013 •
1, 1, 2
1Dr. William M. Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, 2Chicago Medical School, Rosalind Franklin University of Medicine and Science

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Summary
Automatic Translation

Metabolic memory is the phenomenon by which diabetic complications persist and progress unimpeded even after euglycemia is achieved pharmaceutically. Here we describe a diabetes mellitus zebrafish model which is unique in that it allows for the examination of the mitotically transmissible epigenetic components of metabolic memory in vivo.

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Zebrafish Model Diabetes Mellitus Metabolic Memory Glycemic Control Diabetic Complications Gene Expression Epigenetic Changes Environmental Stimuli Metabolic Memory Phenomenon Zebrafish Model Of Type I Diabetes Mellitus Secondary Complications Diabetic Retinopathy Diabetic Nephropathy Impaired Wound Healing Caudal Fin Regeneration Damaged Pancreas Euglycemic State Post-transplant Human Patients Pure Epigenetic Effects
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