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Neuroscience

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JoVE Journal Neuroscience
Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation
 

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Article DOI: 10.3791/53709-v • 09:39 min • June 7th, 2016
June 7th, 2016 •
1, 1, 2, 1
1Institute of Biomedical Sciences, Academia Sinica, 2Department of Anesthesiology, University of Alabama at Birmingham

Kapitel

Summary
Automatic Translation

Studies have shown that cathodal transcranial direct-current stimulation can produce suppressive effects on drug-resistant seizures. In this study, an in vitro experimental setup was devised in which the direct-current stimulation and multielectrode array recording of seizure-like activity were evaluated in mice brain slice preparation. The direct-current stimulation parameters were evaluated.

Tags

Direct-current Stimulation Multi-electrode Array Recording Seizure-like Activity Mice Brain Slice Preparation Experimental Procedure Recording Chamber Direct Current Stimulation Effect Multi-electrode Array Mouse Brain Slice Specific Pathway Evaluation Surgical Instruments Sterilization Skull Exposure And Trimming Olfactory Bulbs Removal Brain Transfer To Beaker Ice Cold ACSF MT-ACC Pathway Sagittal Cut Subcortical Anatomy Display
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