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جيل من Microtumors عن طريق نظام الثقافة 3D Biogel الإنسان وخلايا ورم أرومي دبقي المستمدة من المريض لKinomic التنميط والدواء استجابة اختبار
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Medizin
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JoVE Journal Medizin
Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing
DOI:

09:24 min

June 09, 2016

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Kapitel

  • 00:05Titel
  • 01:31Tumor Disaggregation
  • 04:05Microtumor Generation and Drug Dosing
  • 05:54Microtumor Morphologic and Phenotypic Analyses
  • 07:08Results: Representative Microtumor Growth and Analyses
  • 08:38Conclusion

Summary

Automatische Übersetzung

Patient-derived xenografts of glioblastoma multiforme can be miniaturized into living microtumors using 3D human biogel culture system. This in vivo-like 3D tumor assay is suitable for drug response testing and molecular profiling, including kinomic analysis.

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