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Cancer Research

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JoVE Journal Cancer Research
流动 Cytometry-based 药物筛选系统对促进细胞分化胶质母细胞瘤小分子的鉴定
 
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流动 Cytometry-based 药物筛选系统对促进细胞分化胶质母细胞瘤小分子的鉴定

Article DOI: 10.3791/56176-v • 10:28 min • January 10th, 2018
January 10th, 2018 •
1, 1, 2, 1,3, 1
1Department of Neurological Surgery, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 2Department of Pathology, Johns Hopkins University, School of Medicine, 3Department of Neurological Surgery, University Hospital-Case Medical Center, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine

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提出了一种有效的筛选方案, 以识别小分子, 促进形分化的胶质母细胞瘤干细胞 (GSCs)。该检测是基于一个干细胞分化的记者, 即增强 GFP (eGFP) 的表达是由人胶质细胞促进剂驱动。

Tags

癌症生物学 问题 131 干细胞 胶质瘤 星分化 慢 报告系统 药物筛选 分化治疗 乙酰胆碱 钙信号
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