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JoVE Journal Behavior
Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
 

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Article DOI: 10.3791/62464-v • 06:39 min • June 13th, 2021
June 13th, 2021 •
1,2,3, 4, 1,2,3
1Molecular Developmental Biology Program, Cincinnati Children’s Hospital Medical Center, 2Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, 3Department of Pediatrics, University of Cincinnati College of Medicine, 4Division of Veterinary Services, Cincinnati Children’s Hospital Medical Center

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Summary
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The chronic psychosocial stress (CGS) paradigm employs clinically relevant stressors during pregnancy in mice to model psychiatric disorders of mothers and infants. Here, we provide a step-by-step procedure of applying the CGS paradigm and downstream assessments to validate this model.

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Murine Model Psychosocial Stress Pregnancy Psychiatric Disorders Mothers Infants Chronic Stress Psychosocial Insults Animal Model Paradigms Physical Stressors Stressor Regimen Gestational Day Foreign Objects Developmental Origins Of Adult Disease Adverse Intrauterine Events
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