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JoVE Journal Neuroscience
Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System
 

Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System

Article DOI: 10.3791/63343-v • 06:07 min • December 17th, 2021
December 17th, 2021 •
1, 1,2, 1,3, 1
1Department of Histology and Embryology, Chongqing Key Laboratory of Neurobiology, Brain, and Intelligence Research Key Laboratory of Chongqing Education Commission, Third Military Medical University, 2Research Centre, The Seventh Affiliated Hospital of Sun Yat-sen University, 3School of Medicine, Chongqing University

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Summary
Automatic Translation

Demyelination takes place in multiple central nervous system diseases. A reliable in vivo drug delivery technique is necessary for remyelinating drug testing. This protocol describes an osmotic pump-based method that allows long-term drug delivery directly into the brain parenchyma and improves the drug bioavailability, with broad application in remyelination research.

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Osmotic Pump-based Drug Delivery In Vivo Remyelination Research Central Nervous System Myelin Regeneration Blood-brain Barrier Permeability Peripheral Side Effects Corpus Callosum Bioavailability Of Drugs Stereotaxic Apparatus Midsagittal Incision Cotton Swab Hydrogen Peroxide Cranial Structures Lambda Point Bregma Point Syringe Needle Injection Site Burr Hole
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