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Cancer Research

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JoVE Journal Cancer Research
Spontaneous Murine Model of Anaplastic Thyroid Cancer
 

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Article DOI: 10.3791/64607-v • 05:39 min • February 3rd, 2023
February 3rd, 2023 •
1, 1, 2, 3, 2, 4, 5, 1,6, 2,6
1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, 2Division of Thyroid Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, Department of General Surgery, West China Hospital, Sichuan University, 3Department of Ultrasound, West China Hospital of Sichuan University, Sichuan University, 4Department of Otolaryngology-Head & Neck Surgery and University of Arizona Cancer Center, University of Arizona, 5Center for Translational Medicine, Shenzhen Bay Laboratory, 6Division of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University

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Summary
Automatic Translation

Here, we present a standard pipeline to obtain murine ATC tumors by spontaneous genetically engineered mouse models. Further, we present tumor dynamics and pathological information about the primary and metastasized lesions. This model will help researchers to understand tumorigenesis and facilitate drug discoveries.

Tags

MATC Anaplastic Thyroid Cancer Tumor Dynamics Pathological Information Spontaneous Model Immune System Immune Microenvironment Gene Functions Thyroid Tumor Progression Prognosis Tamoxifen Corn Oil Concentration Intraperitoneally Dissection Tools Mouse-tissue Fixing Solution Sterile PBS Temporary Tissue Storage Thyroid Extraction Dissecting Board Submandibular Gland
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