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JoVE Journal Chemistry
A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)
 

A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)

Article DOI: 10.3791/65200-v • 13:54 min • August 18th, 2023
August 18th, 2023 •
1, 2, 1, 1
1Adsurgo, LLC, 2Arcturus Therapeutics

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Summary
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This protocol provides an approach to formulation optimization over mixture, continuous, and categorical study factors that minimizes subjective choices in the experimental design construction. For the analysis phase, an effective and easy-to-use modeling fitting procedure is employed.

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Lipid Nanoparticle (LNP) Formulation Optimization Designed Mixture-process Experiments Self-validated Ensemble Models (SVEM) Experimental Design Table Analyze Experimental Results Mixture Factors Process Factors Statistical Decisions Joint Optimization Informative Graphics Response Surface Parameter Estimates Factor Settings Recipe Construction Formulation Optimization Approach Error Minimization Statistical Analysis Knowledge Avoidance Experiment Purpose Documentation Measured Responses Varying Factors Constant Factors Study Design Size
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