Friedemann Weber Institute for Virology Philipps-University Marburg Biography Publications Institution JoVE Articles Friedemann Weber has not added a biography. If you are Friedemann Weber and would like to personalize this page please email our Author Liaison for assistance. Publications Segmented Negative-strand RNA Viruses and RIG-I: Divide (your Genome) and Rule Current Opinion in Microbiology. Jun, 2014 | Pubmed ID: 24930021 RIG-I-like Receptors and Negative-strand RNA Viruses: RLRly Bird Catches Some Worms Cytokine & Growth Factor Reviews. May, 2014 | Pubmed ID: 24894317 Structural Insights into RNA Encapsidation and Helical Assembly of the Toscana Virus Nucleoprotein Nucleic Acids Research. 2014 | Pubmed ID: 24688060 Virulence Factor NSs of Rift Valley Fever Virus Recruits the F-box Protein FBXO3 to Degrade Subunit P62 of General Transcription Factor TFIIH Journal of Virology. Mar, 2014 | Pubmed ID: 24403578 Viperin is an Iron-sulfur Protein That Inhibits Genome Synthesis of Tick-borne Encephalitis Virus Via Radical SAM Domain Activity Cellular Microbiology. Jun, 2014 | Pubmed ID: 24245804 Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a is a Type I Interferon Antagonist Journal of Virology. Nov, 2013 | Pubmed ID: 24027320 IFIT2 is an Effector Protein of Type I IFN-mediated Amplification of Lipopolysaccharide (LPS)-induced TNF-α Secretion and LPS-induced Endotoxin Shock Journal of Immunology (Baltimore, Md. : 1950). Oct, 2013 | Pubmed ID: 24014876 Systems to Establish Bunyavirus Genome Replication in the Absence of Transcription Journal of Virology. Jul, 2013 | Pubmed ID: 23698297 Structural Basis for Encapsidation of Genomic RNA by La Crosse Orthobunyavirus Nucleoprotein Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23589854 Incoming RNA Virus Nucleocapsids Containing a 5'-triphosphorylated Genome Activate RIG-I and Antiviral Signaling Cell Host & Microbe. Mar, 2013 | Pubmed ID: 23498958 Human Cell Tropism and Innate Immune System Interactions of Human Respiratory Coronavirus EMC Compared to Those of Severe Acute Respiratory Syndrome Coronavirus Journal of Virology. May, 2013 | Pubmed ID: 23449793 Severe Fever with Thrombocytopenia Virus Glycoproteins Are Targeted by Neutralizing Antibodies and Can Use DC-SIGN As a Receptor for PH-dependent Entry into Human and Animal Cell Lines Journal of Virology. Apr, 2013 | Pubmed ID: 23388721 Structure of Crimean-Congo Hemorrhagic Fever Virus Nucleoprotein: Superhelical Homo-oligomers and the Role of Caspase-3 Cleavage Journal of Virology. Nov, 2012 | Pubmed ID: 22951837 Viral Immune Modulators Perturb the Human Molecular Network by Common and Unique Strategies Nature. Jul, 2012 | Pubmed ID: 22810585 Reverse Genetics of SARS-related Coronavirus Using Vaccinia Virus-based Recombination PloS One. 2012 | Pubmed ID: 22412934 Regulatory, Biosafety and Safety Challenges for Novel Cells As Substrates for Human Vaccines Vaccine. Apr, 2012 | Pubmed ID: 22342707 Induction of DNA Damage Signaling Upon Rift Valley Fever Virus Infection Results in Cell Cycle Arrest and Increased Viral Replication The Journal of Biological Chemistry. Mar, 2012 | Pubmed ID: 22223653 The SARS-coronavirus-host Interactome: Identification of Cyclophilins As Target for Pan-coronavirus Inhibitors PLoS Pathogens. Oct, 2011 | Pubmed ID: 22046132 IFIT1 is an Antiviral Protein That Recognizes 5'-triphosphate RNA Nature Immunology. Jul, 2011 | Pubmed ID: 21642987 Hiding from Intracellular Pattern Recognition Receptors, a Passive Strategy of Flavivirus Immune Evasion Virulence. May-Jun, 2011 | Pubmed ID: 21555916 Completion of Hepatitis C Virus Replication Cycle in Heterokaryons Excludes Dominant Restrictions in Human Non-liver and Mouse Liver Cell Lines PLoS Pathogens. Apr, 2011 | Pubmed ID: 21552323 The ADP-ribose-1''-monophosphatase Domains of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus 229E Mediate Resistance to Antiviral Interferon Responses The Journal of General Virology. Aug, 2011 | Pubmed ID: 21525212 Old World Hantaviruses Do Not Produce Detectable Amounts of DsRNA in Infected Cells and the 5' Termini of Their Genomic RNAs Are Monophosphorylated The Journal of General Virology. May, 2011 | Pubmed ID: 21289157 Interferon Antagonist NSs of La Crosse Virus Triggers a DNA Damage Response-like Degradation of Transcribing RNA Polymerase II The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21118815 Toscana Virus Induces Interferon Although Its NSs Protein Reveals Antagonistic Activity The Journal of General Virology. Jan, 2011 | Pubmed ID: 20861320 Interferon Interplay Helps Tissue Cells to Cope with SARS-coronavirus Infection Virulence. Jul-Aug, 2010 | Pubmed ID: 21178452 Bunyaviridae RNA Polymerases (L-protein) Have an N-terminal, Influenza-like Endonuclease Domain, Essential for Viral Cap-dependent Transcription PLoS Pathogens. 2010 | Pubmed ID: 20862319 Virus-like Particles Expressing the Nucleocapsid Gene As an Efficient Vaccine Against Rift Valley Fever Virus Vector Borne and Zoonotic Diseases (Larchmont, N.Y.). Oct, 2010 | Pubmed ID: 20854024 Extracellular 2'-5' Oligoadenylate Synthetase Stimulates RNase L-independent Antiviral Activity: a Novel Mechanism of Virus-induced Innate Immunity Journal of Virology. Nov, 2010 | Pubmed ID: 20844035 Tick-borne Encephalitis Virus Delays Interferon Induction and Hides Its Double-stranded RNA in Intracellular Membrane Vesicles Journal of Virology. Sep, 2010 | Pubmed ID: 20554782 La Crosse Virus (LACV) Gc Fusion Peptide Mutants Have Impaired Growth and Fusion Phenotypes, but Remain Neurotoxic Virology. Sep, 2010 | Pubmed ID: 20553924 Molecular Biology of Rift Valley Fever Virus The Open Virology Journal. 2010 | Pubmed ID: 20517489 Species-independent Bioassay for Sensitive Quantification of Antiviral Type I Interferons Virology Journal. 2010 | Pubmed ID: 20187932 Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63 Journal of Virology. Jan, 2010 | Pubmed ID: 19864379 Thogoto Virus ML Protein is a Potent Inhibitor of the Interferon Regulatory Factor-7 Transcription Factor The Journal of General Virology. Jan, 2010 | Pubmed ID: 19812269 Bunyaviruses and the Type I Interferon System Viruses. Dec, 2009 | Pubmed ID: 21994579 Interferon Priming Enables Cells to Partially Overturn the SARS Coronavirus-induced Block in Innate Immune Activation The Journal of General Virology. Nov, 2009 | Pubmed ID: 19625461 NSs Protein of Rift Valley Fever Virus Induces the Specific Degradation of the Double-stranded RNA-dependent Protein Kinase Journal of Virology. May, 2009 | Pubmed ID: 19211744 Electron Cryo-microscopy and Single-particle Averaging of Rift Valley Fever Virus: Evidence for GN-GC Glycoprotein Heterodimers Journal of Virology. Apr, 2009 | Pubmed ID: 19193794 Vaccination with Virus-like Particles Protects Mice from Lethal Infection of Rift Valley Fever Virus Virology. Mar, 2009 | Pubmed ID: 19157482 Efficient Production of Rift Valley Fever Virus-like Particles: The Antiviral Protein MxA Can Inhibit Primary Transcription of Bunyaviruses Virology. Mar, 2009 | Pubmed ID: 19155037 Severe Acute Respiratory Syndrome Coronavirus Triggers Apoptosis Via Protein Kinase R but is Resistant to Its Antiviral Activity Journal of Virology. Mar, 2009 | Pubmed ID: 19109397 Interferon and Cytokine Responses to Crimean Congo Hemorrhagic Fever Virus; an Emerging and Neglected Viral Zonoosis Cytokine & Growth Factor Reviews. Oct-Dec, 2008 | Pubmed ID: 19027345 The Interferon Antagonist ML Protein of Thogoto Virus Targets General Transcription Factor IIB Journal of Virology. Nov, 2008 | Pubmed ID: 18768974 T7 RNA Polymerase-dependent and -independent Systems for CDNA-based Rescue of Rift Valley Fever Virus The Journal of General Virology. Sep, 2008 | Pubmed ID: 18753225 Crimean-Congo Hemorrhagic Fever Virus Delays Activation of the Innate Immune Response Journal of Medical Virology. Aug, 2008 | Pubmed ID: 18551619 Processing of Genome 5' Termini As a Strategy of Negative-strand RNA Viruses to Avoid RIG-I-dependent Interferon Induction PloS One. 2008 | Pubmed ID: 18446221 Interferon and Cytokine Responses to SARS-coronavirus Infection Cytokine & Growth Factor Reviews. Apr, 2008 | Pubmed ID: 18321765 Interaction of Hepatitis C Virus with the Type I Interferon System World Journal of Gastroenterology : WJG. Sep, 2007 | Pubmed ID: 17828812 Tula and Puumala Hantavirus NSs ORFs Are Functional and the Products Inhibit Activation of the Interferon-beta Promoter Journal of Medical Virology. Oct, 2007 | Pubmed ID: 17705180 Coronavirus Non-structural Protein 1 is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus Vaccines PLoS Pathogens. Aug, 2007 | Pubmed ID: 17696607 Interferon, Mx, and Viral Countermeasures Cytokine & Growth Factor Reviews. Oct-Dec, 2007 | Pubmed ID: 17683972 La Crosse Bunyavirus Nonstructural Protein NSs Serves to Suppress the Type I Interferon System of Mammalian Hosts Journal of Virology. May, 2007 | Pubmed ID: 17344298 Viral Suppression of the Interferon System Biochimie. Jun-Jul, 2007 | Pubmed ID: 17336442 The Intracellular Sites of Early Replication and Budding of SARS-coronavirus Virology. May, 2007 | Pubmed ID: 17210170 Control of Coronavirus Infection Through Plasmacytoid Dendritic-cell-derived Type I Interferon Blood. Feb, 2007 | Pubmed ID: 16985170 RIG-I-mediated Antiviral Responses to Single-stranded RNA Bearing 5'-phosphates Science (New York, N.Y.). Nov, 2006 | Pubmed ID: 17038589 Interaction of Severe Acute Respiratory Syndrome-associated Coronavirus with Dendritic Cells The Journal of General Virology. Jul, 2006 | Pubmed ID: 16760397 Neurons Produce Type I Interferon During Viral Encephalitis Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16682623 Double-stranded RNA is Produced by Positive-strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-strand RNA Viruses Journal of Virology. May, 2006 | Pubmed ID: 16641297 Inhibition of Cytokine Gene Expression and Induction of Chemokine Genes in Non-lymphatic Cells Infected with SARS Coronavirus Virology Journal. 2006 | Pubmed ID: 16571117 Global Suppression of the Host Antiviral Response by Ebola- and Marburgviruses: Increased Antagonism of the Type I Interferon Response is Associated with Enhanced Virulence Journal of Virology. Mar, 2006 | Pubmed ID: 16501110 Induction of Interferon Synthesis by the PKR-inhibitory VA RNAs of Adenoviruses Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Jan, 2006 | Pubmed ID: 16426142 A Target on the Move: Innate and Adaptive Immune Escape Strategies of Hepatitis C Virus Antiviral Research. Mar, 2006 | Pubmed ID: 16413618 The Interferon Response Circuit: Induction and Suppression by Pathogenic Viruses Virology. Jan, 2006 | Pubmed ID: 16364743 Activation of Innate Defense Against a Paramyxovirus is Mediated by RIG-I and TLR7 and TLR8 in a Cell-type-specific Manner Journal of Virology. Oct, 2005 | Pubmed ID: 16188996 Efficient CDNA-based Rescue of La Crosse Bunyaviruses Expressing or Lacking the Nonstructural Protein NSs Journal of Virology. Aug, 2005 | Pubmed ID: 16051834 Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-step Model for Activation of Interferon Regulatory Factor 3 Journal of Virology. Feb, 2005 | Pubmed ID: 15681410 Thogoto Virus ML Protein Suppresses IRF3 Function Virology. Jan, 2005 | Pubmed ID: 15582653 Inverse Interference: How Viruses Fight the Interferon System Viral Immunology. 2004 | Pubmed ID: 15671747 NSs Protein of Rift Valley Fever Virus Blocks Interferon Production by Inhibiting Host Gene Transcription Journal of Virology. Sep, 2004 | Pubmed ID: 15331713 High-efficiency Detection of Severe Acute Respiratory Syndrome Virus Genetic Material Journal of Clinical Microbiology. Jun, 2004 | Pubmed ID: 15184466 Inhibition of RNA Polymerase II Phosphorylation by a Viral Interferon Antagonist The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15150262 The Antiviral Effect of Interferon-beta Against SARS-coronavirus is Not Mediated by MxA Protein Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology. Jul, 2004 | Pubmed ID: 15135736 Inhibition of Dugbe Nairovirus Replication by Human MxA Protein Virus Research. Jan, 2004 | Pubmed ID: 14687945 Viral Evasion of the Interferon System: Old Viruses, New Tricks Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Apr, 2003 | Pubmed ID: 12856333 Bunyamwera Virus Nonstructural Protein NSs Counteracts Interferon Regulatory Factor 3-mediated Induction of Early Cell Death Journal of Virology. Jul, 2003 | Pubmed ID: 12829839 Functional L Polymerase of La Crosse Virus Allows in Vivo Reconstitution of Recombinant Nucleocapsids The Journal of General Virology. May, 2003 | Pubmed ID: 12692286 Activation of PKR by Bunyamwera Virus is Independent of the Viral Interferon Antagonist NSs Journal of Virology. May, 2003 | Pubmed ID: 12692253 Novel Gene Product of Thogoto Virus Segment 6 Codes for an Interferon Antagonist Journal of Virology. Feb, 2003 | Pubmed ID: 12552016 Antigenic Drift, Antigenic Shift and Interferon Antagonists: How Bunyaviruses Counteract the Immune System Virus Research. Sep, 2002 | Pubmed ID: 12297332 Bunyamwera Bunyavirus Nonstructural Protein NSs Counteracts the Induction of Alpha/beta Interferon Journal of Virology. Aug, 2002 | Pubmed ID: 12133999 Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE Michaela Weber1, Friedemann Weber1 1Institute for Virology, Philipps-University Marburg JoVE 51415 Inmunología e infección
Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE Michaela Weber1, Friedemann Weber1 1Institute for Virology, Philipps-University Marburg JoVE 51415 Inmunología e infección