Jeannie Chen Zilkha Neurogenetic Institute, Keck School of Medicine University of Southern California Biography Publications Institution JoVE Articles Jeannie Chen has not added a biography. If you are Jeannie Chen and would like to personalize this page please email our Author Liaison for assistance. Publications Huntingtin Fibrils with Different Toxicity, Structure, and Seeding Potential Can Be Interconverted Nature Communications. 07, 2021 | Pubmed ID: 34257293 Biological Role of Arrestin-1 Oligomerization The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 10, 2020 | Pubmed ID: 32948676 Dark Noise and Retinal Degeneration from D190N-rhodopsin Proceedings of the National Academy of Sciences of the United States of America. 09, 2020 | Pubmed ID: 32873651 Diminished Cone Sensitivity in Cpfl3 Mice Is Caused by Defective Transducin Signaling Investigative Ophthalmology & Visual Science. 04, 2020 | Pubmed ID: 32315379 Isoelectric Focusing to Quantify Rhodopsin Phosphorylation in Mouse Retina Bio-protocol. Jul, 2019 | Pubmed ID: 33654813 Activation of Rod Input in a Model of Retinal Degeneration Reverses Retinal Remodeling and Induces Formation of Functional Synapses and Recovery of Visual Signaling in the Adult Retina The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 08, 2019 | Pubmed ID: 31285302 Elementary Response Triggered by Transducin in Retinal Rods Proceedings of the National Academy of Sciences of the United States of America. 03, 2019 | Pubmed ID: 30796193 The PDE6 Mutation in the Rd10 Retinal Degeneration Mouse Model Causes Protein Mislocalization and Instability and Promotes Cell Death Through Increased Ion Influx The Journal of Biological Chemistry. 10, 2018 | Pubmed ID: 30126843 Enhanced Mutant Compensates for Defects in Rhodopsin Phosphorylation in the Presence of Endogenous Arrestin-1 Frontiers in Molecular Neuroscience. 2018 | Pubmed ID: 29973866 Regulation of Calcium Homeostasis in the Outer Segments of Rod and Cone Photoreceptors Progress in Retinal and Eye Research. 11, 2018 | Pubmed ID: 29883715 Guanylate Cyclase-activating Protein 2 Contributes to Phototransduction and Light Adaptation in Mouse Cone Photoreceptors The Journal of Biological Chemistry. 05, 2018 | Pubmed ID: 29549122 Phenotypic Characterization of P23H and S334ter Rhodopsin Transgenic Rat Models of Inherited Retinal Degeneration Experimental Eye Research. 02, 2018 | Pubmed ID: 29122605 The Na/Ca, K Exchanger NCKX4 is Required for Efficient Cone-mediated Vision ELife. 06, 2017 | Pubmed ID: 28650316 Separation of Photoreceptor Cell Compartments in Mouse Retina for Protein Analysis Molecular Neurodegeneration. 04, 2017 | Pubmed ID: 28399904 Two Pathways of Rod Photoreceptor Cell Death Induced by Elevated CGMP Human Molecular Genetics. Jun, 2017 | Pubmed ID: 28379353 The GCaMP-R Family of Genetically Encoded Ratiometric Calcium Indicators ACS Chemical Biology. 04, 2017 | Pubmed ID: 28195691 Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice Scientific Reports. Feb, 2017 | Pubmed ID: 28145503 The Na(+)/Ca(2+), K(+) Exchanger 2 Modulates Mammalian Cone Phototransduction Scientific Reports. 09, 2016 | Pubmed ID: 27580676 Effect of Rhodopsin Phosphorylation on Dark Adaptation in Mouse Rods The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 06, 2016 | Pubmed ID: 27358455 A New Mouse Model for Stationary Night Blindness with Mutant Slc24a1 Explains the Pathophysiology of the Associated Human Disease Human Molecular Genetics. Oct, 2015 | Pubmed ID: 26246500 C-terminal Threonines and Serines Play Distinct Roles in the Desensitization of Rhodopsin, a G Protein-coupled Receptor ELife. Apr, 2015 | Pubmed ID: 25910054 Regulation of Mammalian Cone Phototransduction by Recoverin and Rhodopsin Kinase The Journal of Biological Chemistry. Apr, 2015 | Pubmed ID: 25673692 Induction of the Unfolded Protein Response by Constitutive G-protein Signaling in Rod Photoreceptor Cells The Journal of Biological Chemistry. Oct, 2014 | Pubmed ID: 25183010 Functional EF-hands in Neuronal Calcium Sensor GCAP2 Determine Its Phosphorylation State and Subcellular Distribution in Vivo, and Are Essential for Photoreceptor Cell Integrity PLoS Genetics. Jul, 2014 | Pubmed ID: 25058152 The Physiological Roles of Arrestin-1 in Rod Photoreceptor Cells Handbook of Experimental Pharmacology. 2014 | Pubmed ID: 24292825 Rapid Degeneration of Rod Photoreceptors Expressing Self-association-deficient Arrestin-1 Mutant Cellular Signalling. Dec, 2013 | Pubmed ID: 24012956 Visual Arrestin Interaction with Clathrin Adaptor AP-2 Regulates Photoreceptor Survival in the Vertebrate Retina Proceedings of the National Academy of Sciences of the United States of America. Jun, 2013 | Pubmed ID: 23690606 Functional Comparison of Rod and Cone Gα(t) on the Regulation of Light Sensitivity The Journal of Biological Chemistry. Feb, 2013 | Pubmed ID: 23288843 Diurnal, Localized Exposure of Phosphatidylserine by Rod Outer Segment Tips in Wild-type but Not Itgb5-/- or Mfge8-/- Mouse Retina Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22566632 对杆感光器信号 γ 亚基的 CGMP 磷酸二酯酶 (PDE6) ILE86TER 突变的影响。 Cellular Signalling. Jan, 2012 | Pubmed ID: 21920434 Progressive Reduction of Its Expression in Rods Reveals Two Pools of Arrestin-1 in the Outer Segment with Different Roles in Photoresponse Recovery PloS One. 2011 | Pubmed ID: 21818392 在鼠标锥 Phototransduction 鸟苷酰环化酶调制的作用。 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2011 | Pubmed ID: 21632921 杆外部分视黄醇形成的 Abca4,arrestin,视紫红质激酶和视紫红质 Palmitylation 无关。 Investigative Ophthalmology & Visual Science. May, 2011 | Pubmed ID: 21398289 Arrestin-1 Expression Level in Rods: Balancing Functional Performance and Photoreceptor Health Neuroscience. Feb, 2011 | Pubmed ID: 21075174 Channel Modulation and the Mechanism of Light Adaptation in Mouse Rods The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2010 | Pubmed ID: 21123569 Monitoring Apoptosis and Neuronal Degeneration by Real-time Detection of Phosphatidylserine Externalization Using a Polarity-sensitive Indicator of Viability and Apoptosis Nature Protocols. Aug, 2010 | Pubmed ID: 20671723 Q344ter Mutation Causes Mislocalization of Rhodopsin Molecules That Are Catalytically Active: a Mouse Model of Q344ter-induced Retinal Degeneration PloS One. Jun, 2010 | Pubmed ID: 20532191 Engineering a Polarity-sensitive Biosensor for Time-lapse Imaging of Apoptotic Processes and Degeneration Nature Methods. Jan, 2010 | Pubmed ID: 19966809 Soluble and Mature Amyloid Fibrils in Drusen Deposits Investigative Ophthalmology & Visual Science. Mar, 2010 | Pubmed ID: 19892876 Enhanced Arrestin Facilitates Recovery and Protects Rods Lacking Rhodopsin Phosphorylation Current Biology : CB. Apr, 2009 | Pubmed ID: 19361994 Structure of Membrane-bound Alpha-synuclein from Site-directed Spin Labeling and Computational Refinement Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19066219 Formation of Soluble Amyloid Oligomers and Amyloid Fibrils by the Multifunctional Protein Vitronectin Molecular Neurodegeneration. Oct, 2008 | Pubmed ID: 18939994 短波信号传输性能锥视觉色素和在 Phototransduction 中的作用。 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2007 | Pubmed ID: 17881515 Investigation of Alpha-synuclein Fibril Structure by Site-directed Spin Labeling The Journal of Biological Chemistry. Aug, 2007 | Pubmed ID: 17573347 Functional Comparisons of Visual Arrestins in Rod Photoreceptors of Transgenic Mice Investigative Ophthalmology & Visual Science. May, 2007 | Pubmed ID: 17460248 Molecular Properties of Rhodopsin and Rod Function The Journal of Biological Chemistry. Mar, 2007 | Pubmed ID: 17194706 Stable Rhodopsin/arrestin Complex Leads to Retinal Degeneration in a Transgenic Mouse Model of Autosomal Dominant Retinitis Pigmentosa The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2006 | Pubmed ID: 17108167 Drusen Deposits Associated with Aging and Age-related Macular Degeneration Contain Nonfibrillar Amyloid Oligomers The Journal of Clinical Investigation. Feb, 2006 | Pubmed ID: 16453022 Light-dependent Redistribution of Arrestin in Vertebrate Rods is an Energy-independent Process Governed by Protein-protein Interactions Neuron. May, 2005 | Pubmed ID: 15944125 Structure of Membrane-bound Alpha-synuclein Studied by Site-directed Spin Labeling Proceedings of the National Academy of Sciences of the United States of America. Jun, 2004 | Pubmed ID: 15155902 Structural Organization of Alpha-synuclein Fibrils Studied by Site-directed Spin Labeling The Journal of Biological Chemistry. Sep, 2003 | Pubmed ID: 12815044 Mouse Models to Study GCAP Functions in Intact Photoreceptors Advances in Experimental Medicine and Biology. 2002 | Pubmed ID: 12596933 The Carboxyl-terminal Domain is Essential for Rhodopsin Transport in Rod Photoreceptors Vision Research. Feb, 2002 | Pubmed ID: 11853757 Role of Guanylate Cyclase-activating Proteins (GCAPs) in Setting the Flash Sensitivity of Rod Photoreceptors Proceedings of the National Academy of Sciences of the United States of America. Aug, 2001 | Pubmed ID: 11493703 Expression of Bcl-2 Protects Against Photoreceptor Degeneration in Retinal Degeneration Slow (rds) Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2000 | Pubmed ID: 10704489 Abnormal Photoresponses and Light-induced Apoptosis in Rods Lacking Rhodopsin Kinase Proceedings of the National Academy of Sciences of the United States of America. Mar, 1999 | Pubmed ID: 10097103 两种剥离方法,用于分离小鼠视网膜中的光感受器细胞区室以进行蛋白质分析 Kasey Rose1, Sowmya Lokappa1, Jeannie Chen1,2 1Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 2Department of Cell & Neurobiology, Keck School of Medicine, University of Southern California JoVE 62977 Neurociencia
两种剥离方法,用于分离小鼠视网膜中的光感受器细胞区室以进行蛋白质分析 Kasey Rose1, Sowmya Lokappa1, Jeannie Chen1,2 1Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 2Department of Cell & Neurobiology, Keck School of Medicine, University of Southern California JoVE 62977 Neurociencia