Joris Vriens Department Development & Regeneration University of Leuven Biography Publications Institution JoVE Articles Joris VriensFull Profe Joris Vriens is Full Professor at the Department Development & Regeneration at the University of Leuven in Belgium. He received his PhD in Biomedical Sciences at the University of Leuven investigating the different activation mechanism of the TRPV4 ion channel. As a post doctoral researcher he went abroad to the lab of Prof Clapham at the Harvard Medical School, Boston, US to assess the Total Internal Reflection Fluorescence Microscopy to study the trafficking of ion channels to the plasma membrane. After his post doc period he returned to the lab of ion channel research where he initiated new research projects on TRPM3. Together with prof Voets he characterized TRPM3 as an important nociceptor in the peripheral nerve system and an interesting target for the development of novel analgesics for the treatment of different types of pain. In 2011, Vriens became the head of the lab of endometrium, endometriosis and reproductive medicine (LEERM) at the Leuven University. His research group continues to pioneer and investigate the role of ion channels in the female reproductive system with a particular focus on endometrial receptivity and assess the role of ion channels in placental function and development. The lab of Vriens is part of the Center of Ion Channel Research headed by Prof Voets. Publications Upregulation of TRPM3 in Nociceptors Innervating Inflamed Tissue ELife. 09, 2020 | Pubmed ID: 32880575 Reply To: Heat Detection by the TRPM2 Ion Channel Nature. Aug, 2020 | Pubmed ID: 32788731 Pharmacological Properties of TRPM3 Isoforms Are Determined by the Length of the Pore Loop British Journal of Pharmacology. Aug, 2020 | Pubmed ID: 32780479 Gain of Channel Function and Modified Gating Properties in TRPM3 Mutants Causing Intellectual Disability and Epilepsy ELife. May, 2020 | Pubmed ID: 32427099 Double-label Immunohistochemistry to Assess Labyrinth Structure of the Mouse Placenta with Stereology Placenta. 05, 2020 | Pubmed ID: 32421534 Mimicking Sampson's Retrograde Menstrual Theory in Rats: A New Rat Model for Ongoing Endometriosis-Associated Pain International Journal of Molecular Sciences. Mar, 2020 | Pubmed ID: 32230898 The Sensory Coding of Warm Perception Neuron. 06, 2020 | Pubmed ID: 32208171 Functional Expression and Pharmacological Modulation of TRPM3 in Human Sensory Neurons British Journal of Pharmacology. Jun, 2020 | Pubmed ID: 31985045 Targeting TRP Channels - Valuable Alternatives to Combat Pain, Lower Urinary Tract Disorders, and Type 2 Diabetes? Trends in Pharmacological Sciences. 09, 2019 | Pubmed ID: 31395287 Heat Sensing Involves a TRiPlet of Ion Channels British Journal of Pharmacology. 10, 2019 | Pubmed ID: 31372975 Patient-derived Organoids from Endometrial Disease Capture Clinical Heterogeneity and Are Amenable to Drug Screening Nature Cell Biology. 08, 2019 | Pubmed ID: 31371824 High-resolution Contrast-enhanced MicroCT Reveals the True Three-dimensional Morphology of the Murine Placenta Proceedings of the National Academy of Sciences of the United States of America. 07, 2019 | Pubmed ID: 31249139 Functional Expression of the Mechanosensitive PIEZO1 Channel in Primary Endometrial Epithelial Cells and Endometrial Organoids Scientific Reports. 02, 2019 | Pubmed ID: 30741991 Establishing Life is a Calcium-dependent TRiP: Transient Receptor Potential Channels in Reproduction Biochimica Et Biophysica Acta. Molecular Cell Research. 11, 2018 | Pubmed ID: 30798946 Functional Expression of TRP Ion Channels in Endometrial Stromal Cells of Endometriosis Patients International Journal of Molecular Sciences. Aug, 2018 | Pubmed ID: 30134548 Mutations in the Voltage-sensing Domain Affect the Alternative Ion Permeation Pathway in the TRPM3 Channel The Journal of Physiology. 06, 2018 | Pubmed ID: 29604058 Optimization of Endometrial Decidualization in the Menstruating Mouse Model for Preclinical Endometriosis Research Reproductive Sciences (Thousand Oaks, Calif.). 11, 2018 | Pubmed ID: 29455621 Sensing the Heat with TRPM3 Pflugers Archiv : European Journal of Physiology. 05, 2018 | Pubmed ID: 29305649 Of Mice and Women: A Laparoscopic Mouse Model for Endometriosis Journal of Minimally Invasive Gynecology. May - Jun, 2018 | Pubmed ID: 29032250 TRP Channel Pores and Local Calcium Signals Cell Calcium. 09, 2017 | Pubmed ID: 28807146 The Functional Expression of Transient Receptor Potential Channels in the Mouse Endometrium Human Reproduction (Oxford, England). Jan, 2017 | Pubmed ID: 28077439 A Cellular Pathway Controlling Functional Plasma Membrane Incorporation of the Cold Sensor TRPM8 Temperature (Austin, Tex.). Month, 2016 | Pubmed ID: 28090554 Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy Cancer Cell. Dec, 2016 | Pubmed ID: 27866851 Definition of Two Agonist Types at the Mammalian Cold-activated Channel TRPM8 ELife. Jul, 2016 | Pubmed ID: 27449282 TRPV4 is Associated with Central Rather Than Nephrogenic Osmoregulation Pflugers Archiv : European Journal of Physiology. Sep, 2016 | Pubmed ID: 27364478 Laparoscopic Surgery: A New Technique to Induce Endometriosis in a Mouse Model Reproductive Sciences (Thousand Oaks, Calif.). Oct, 2016 | Pubmed ID: 26994066 Urine of Preterm Neonates As a Novel Source of Kidney Progenitor Cells Journal of the American Society of Nephrology : JASN. Sep, 2016 | Pubmed ID: 26940093 VAMP7 Regulates Constitutive Membrane Incorporation of the Cold-activated Channel TRPM8 Nature Communications. Feb, 2016 | Pubmed ID: 26843440 Signature and Pathophysiology of Non-canonical Pores in Voltage-Dependent Cation Channels Reviews of Physiology, Biochemistry and Pharmacology. Month, 2016 | Pubmed ID: 26791748 TRPM3 in Temperature Sensing and Beyond Temperature (Austin, Tex.). Apr-Jun, 2015 | Pubmed ID: 27227024 Regulation of the Transient Receptor Potential Channel TRPM3 by Phosphoinositides The Journal of General Physiology. Jul, 2015 | Pubmed ID: 26123194 Functional Expression of Transient Receptor Potential Channels in Human Endometrial Stromal Cells During the Luteal Phase of the Menstrual Cycle Human Reproduction (Oxford, England). Jun, 2015 | Pubmed ID: 25820697 Activation of TRPM3 by a Potent Synthetic Ligand Reveals a Role in Peptide Release Proceedings of the National Academy of Sciences of the United States of America. Mar, 2015 | Pubmed ID: 25733887 TRPV4 Participates in the Establishment of Trailing Adhesions and Directional Persistence of Migrating Cells Pflugers Archiv : European Journal of Physiology. Oct, 2015 | Pubmed ID: 25559845 Peripheral Thermosensation in Mammals Nature Reviews. Neuroscience. Sep, 2014 | Pubmed ID: 25053448 Opening of an Alternative Ion Permeation Pathway in a Nociceptor TRP Channel Nature Chemical Biology. Mar, 2014 | Pubmed ID: 24390427 Vascular Hypoxic Preconditioning Relies on TRPV4-dependent Calcium Influx and Proper Intercellular Gap Junctions Communication Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2012 | Pubmed ID: 22814746 Cholesterol Loss During Glutamate-mediated Excitotoxicity The EMBO Journal. Apr, 2012 | Pubmed ID: 22343944 The 'headache Tree' Via Umbellulone and TRPA1 Activates the Trigeminovascular System Brain : a Journal of Neurology. Feb, 2012 | Pubmed ID: 22036959 TRPM3 is a Nociceptor Channel Involved in the Detection of Noxious Heat Neuron. May, 2011 | Pubmed ID: 21555074 Inhibition of the Cation Channel TRPV4 Improves Bladder Function in Mice and Rats with Cyclophosphamide-induced Cystitis Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 20956320 Dominant TRPV4 Mutations in Nonlethal and Lethal Metatropic Dysplasia American Journal of Medical Genetics. Part A. May, 2010 | Pubmed ID: 20425821 Functional Characterization of Transient Receptor Potential Channels in Mouse Urothelial Cells American Journal of Physiology. Renal Physiology. Mar, 2010 | Pubmed ID: 20015940 TRPM1 Forms Ion Channels Associated with Melanin Content in Melanocytes Science Signaling. May, 2009 | Pubmed ID: 19436059 Pharmacology of Vanilloid Transient Receptor Potential Cation Channels Molecular Pharmacology. Jun, 2009 | Pubmed ID: 19297520 Mutations in the Gene Encoding the Calcium-permeable Ion Channel TRPV4 Produce Spondylometaphyseal Dysplasia, Kozlowski Type and Metatropic Dysplasia American Journal of Human Genetics. Mar, 2009 | Pubmed ID: 19232556 Herbal Compounds and Toxins Modulating TRP Channels Current Neuropharmacology. Mar, 2008 | Pubmed ID: 19305789 TRPV4-mediated Calcium Influx Regulates Terminal Differentiation of Osteoclasts Cell Metabolism. Sep, 2008 | Pubmed ID: 18762026 Role of Cytochrome P450-dependent Transient Receptor Potential V4 Activation in Flow-induced Vasodilatation Cardiovascular Research. Dec, 2008 | Pubmed ID: 18682435 Citral Sensing by Transient [corrected] Receptor Potential Channels in Dorsal Root Ganglion Neurons PloS One. May, 2008 | Pubmed ID: 18461159 Deletion of the Transient Receptor Potential Cation Channel TRPV4 Impairs Murine Bladder Voiding The Journal of Clinical Investigation. Nov, 2007 | Pubmed ID: 17948126 Determinants of 4 Alpha-phorbol Sensitivity in Transmembrane Domains 3 and 4 of the Cation Channel TRPV4 The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17341586 TRPV1 is Involved in Stretch-evoked Contractile Changes in the Rat Autonomous Bladder Model: a Study with Piperine, a New TRPV1 Agonist Neurourology and Urodynamics. Month, 2007 | Pubmed ID: 17266134 Invertebrate TRP Proteins As Functional Models for Mammalian Channels Pflugers Archiv : European Journal of Physiology. Dec, 2004 | Pubmed ID: 15480752 TRPV Channels and Modulation by Hepatocyte Growth Factor/scatter Factor in Human Hepatoblastoma (HepG2) Cells Cell Calcium. Jul, 2004 | Pubmed ID: 15126053 TRPV4 Calcium Entry Channel: a Paradigm for Gating Diversity American Journal of Physiology. Cell Physiology. Feb, 2004 | Pubmed ID: 14707014 Anandamide and Arachidonic Acid Use Epoxyeicosatrienoic Acids to Activate TRPV4 Channels Nature. Jul, 2003 | Pubmed ID: 12879072 Modulation of TRPV4 Gating by Intra- and Extracellular Ca2+ Cell Calcium. May-Jun, 2003 | Pubmed ID: 12765694 The TRPV4 Channel: Structure-function Relationship and Promiscuous Gating Behaviour Pflugers Archiv : European Journal of Physiology. Jun, 2003 | Pubmed ID: 12715179 Heat-evoked Activation of TRPV4 Channels in a HEK293 Cell Expression System and in Native Mouse Aorta Endothelial Cells The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12354759 Molecular Determinants of Permeation Through the Cation Channel TRPV4 The Journal of Biological Chemistry. Sep, 2002 | Pubmed ID: 12093812 Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives The Journal of Biological Chemistry. Apr, 2002 | Pubmed ID: 11827975 Horisontella Hippocampal skivor av mushjärnan Evelien Van Hoeymissen1,2, Koenraad Philippaert2, Rudi Vennekens2, Joris Vriens*1, Katharina Held*1,2 1Laboratory of Endometrium, Endometriosis and Reproductive Medicine, Department of Development and Regeneration, KU Leuven, 2Laboratory of Ion Channel Research, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium and Department of Molecular Medicine, KU Leuven JoVE 61753 Neurociencia Isolering av Mouse Endometrial epitelceller och stromaceller celler för Katrien De Clercq*1, Aurélie Hennes*1, Joris Vriens1 1Department of Development and Regeneration, Katholieke Universiteit Leuven (KU Leuven) Biología del desarrollo
Horisontella Hippocampal skivor av mushjärnan Evelien Van Hoeymissen1,2, Koenraad Philippaert2, Rudi Vennekens2, Joris Vriens*1, Katharina Held*1,2 1Laboratory of Endometrium, Endometriosis and Reproductive Medicine, Department of Development and Regeneration, KU Leuven, 2Laboratory of Ion Channel Research, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium and Department of Molecular Medicine, KU Leuven JoVE 61753 Neurociencia
Isolering av Mouse Endometrial epitelceller och stromaceller celler för Katrien De Clercq*1, Aurélie Hennes*1, Joris Vriens1 1Department of Development and Regeneration, Katholieke Universiteit Leuven (KU Leuven) Biología del desarrollo