Michael Simons Yale Cardiovascular Research Center, Department of Internal Medicine Yale University School of Medicine Biography Publications Institution JoVE Articles Michael Simons has not added a biography. If you are Michael Simons and would like to personalize this page please email our Author Liaison for assistance. Publications BMPR1A Promotes ID2-ZEB1 Interaction to Suppress Excessive Endothelial to Mesenchymal Transition Cardiovascular Research. Sep, 2022 | Pubmed ID: 36166408 FGFR1 SUMOylation Coordinates Endothelial Angiogenic Signaling in Angiogenesis Proceedings of the National Academy of Sciences of the United States of America. 06, 2022 | Pubmed ID: 35733256 Flow Goes Forward and Cells Step Backward: Endothelial Migration Experimental & Molecular Medicine. 06, 2022 | Pubmed ID: 35701563 Endothelium-derived Lactate is Required for Pericyte Function and Blood-brain Barrier Maintenance The EMBO Journal. Mar, 2022 | Pubmed ID: 35243676 Identification of Driver Genes for Critical Forms of COVID-19 in a Deeply Phenotyped Young Patient Cohort Science Translational Medicine. Jan, 2022 | Pubmed ID: 34698500 MEKK3-TGFβ Crosstalk Regulates Inward Arterial Remodeling Proceedings of the National Academy of Sciences of the United States of America. 12, 2021 | Pubmed ID: 34911761 Fibroblast Growth Factors: the Keepers of Endothelial Normalcy The Journal of Clinical Investigation. 09, 2021 | Pubmed ID: 34623324 Role of Venous Endothelial Cells in Developmental and Pathologic Angiogenesis Circulation. 10, 2021 | Pubmed ID: 34474596 Emerging Roles of PLCγ1 in Endothelial Biology Science Signaling. 08, 2021 | Pubmed ID: 34344833 Developmental Perspectives on Arterial Fate Specification Frontiers in Cell and Developmental Biology. 2021 | Pubmed ID: 34249941 The Quiescent Endothelium: Signalling Pathways Regulating Organ-specific Endothelial Normalcy Nature Reviews. Cardiology. 08, 2021 | Pubmed ID: 33627876 Phenotype Projection of Endothelial ERK1/2 Signaling Aging. 06, 2020 | Pubmed ID: 32530820 Endothelial-to-Mesenchymal Transition, Vascular Inflammation, and Atherosclerosis Frontiers in Cardiovascular Medicine. 2020 | Pubmed ID: 32478094 Smooth Muscle Cell Reprogramming in Aortic Aneurysms Cell Stem Cell. 04, 2020 | Pubmed ID: 32243809 Resilience, Disease and the Age of Single Cell Science Aging. 02, 2020 | Pubmed ID: 32039835 FRS2α-dependent Cell Fate Transition During Endocardial Cushion Morphogenesis Developmental Biology. 02, 2020 | Pubmed ID: 31669335 Isoform-Specific Roles of ERK1 and ERK2 in Arteriogenesis Cells. 12, 2019 | Pubmed ID: 31877781 Endothelial TGF-β Signalling Drives Vascular Inflammation and Atherosclerosis Nature Metabolism. 09, 2019 | Pubmed ID: 31572976 Author Correction: SUMOylation of VEGFR2 Regulates Its Intracellular Trafficking and Pathological Angiogenesis Nature Communications. Aug, 2019 | Pubmed ID: 31417083 Endothelial ERK1/2 Signaling Maintains Integrity of the Quiescent Endothelium The Journal of Experimental Medicine. 08, 2019 | Pubmed ID: 31196980 Publisher Correction: N-terminal Syndecan-2 Domain Selectively Enhances 6-O Heparan Sulfate Chains Sulfation and Promotes VEGFA-dependent Neovascularization Nature Communications. 05, 2019 | Pubmed ID: 31064993 N-terminal Syndecan-2 Domain Selectively Enhances 6-O Heparan Sulfate Chains Sulfation and Promotes VEGFA-dependent Neovascularization Nature Communications. 04, 2019 | Pubmed ID: 30952866 Metabolic Analysis of Lymphatic Endothelial Cells Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 30242770 SUMOylation of VEGFR2 Regulates Its Intracellular Trafficking and Pathological Angiogenesis Nature Communications. 08, 2018 | Pubmed ID: 30120232 Lacteal Junction Zippering Protects Against Diet-induced Obesity Science (New York, N.Y.). 08, 2018 | Pubmed ID: 30093598 Fibroblast Growth Factor-transforming Growth Factor Beta Dialogues, Endothelial Cell to Mesenchymal Transition, and Atherosclerosis Current Opinion in Lipidology. 10, 2018 | Pubmed ID: 30080704 Recent Advances in Understanding Lymphangiogenesis and Metabolism F1000Research. 2018 | Pubmed ID: 30079231 Endothelial Metabolic Control of Lymphangiogenesis BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. 06, 2018 | Pubmed ID: 29750374 Reprogramming the Endocardium: Trials and Tribulations Circulation Research. 03, 2018 | Pubmed ID: 29599272 Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis Arteriosclerosis, Thrombosis, and Vascular Biology. 04, 2018 | Pubmed ID: 29449333 The Rab-effector Protein RABEP2 Regulates Endosomal Trafficking to Mediate Vascular Endothelial Growth Factor Receptor-2 (VEGFR2)-dependent Signaling The Journal of Biological Chemistry. 03, 2018 | Pubmed ID: 29425100 SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling Circulation Research. Sep, 2017 | Pubmed ID: 28760777 FGF-dependent Metabolic Control of Vascular Development Nature. 05, 2017 | Pubmed ID: 28467822 Post-endocytic Sorting of Plexin-D1 Controls Signal Transduction and Development of Axonal and Vascular Circuits Nature Communications. 02, 2017 | Pubmed ID: 28224988 The Molecular Basis of Endothelial Cell Plasticity Nature Communications. 02, 2017 | Pubmed ID: 28181491 Modulation of VEGF Receptor 2 Signaling by Protein Phosphatases Pharmacological Research. 01, 2017 | Pubmed ID: 27888154 Syndecan 4 Controls Lymphatic Vasculature Remodeling During Mouse Embryonic Development Development (Cambridge, England). Dec, 2016 | Pubmed ID: 27789626 Fibroblast Growth Factor (FGF) Signaling Regulates Transforming Growth Factor Beta (TGFβ)-dependent Smooth Muscle Cell Phenotype Modulation Scientific Reports. 09, 2016 | Pubmed ID: 27634335 Sympathetic Innervation Promotes Arterial Fate by Enhancing Endothelial ERK Activity Circulation Research. Aug, 2016 | Pubmed ID: 27354211 Smooth Muscle FGF/TGFβ Cross Talk Regulates Atherosclerosis Progression EMBO Molecular Medicine. 07, 2016 | Pubmed ID: 27189169 The Expanding Role of Neuropilin: Regulation of Transforming Growth Factor-β and Platelet-derived Growth Factor Signaling in the Vasculature Current Opinion in Hematology. May, 2016 | Pubmed ID: 26849476 When Endothelial Cells Go Rogue EMBO Molecular Medicine. Jan, 2016 | Pubmed ID: 26613939 Endothelial-to-mesenchymal Transition Drives Atherosclerosis Progression The Journal of Clinical Investigation. Oct, 2015 | Pubmed ID: 26517696 Endothelial MiR-17∼92 Cluster Negatively Regulates Arteriogenesis Via MiRNA-19 Repression of WNT Signaling Proceedings of the National Academy of Sciences of the United States of America. Oct, 2015 | Pubmed ID: 26417068 When It is Better to Regress: Dynamics of Vascular Pruning PLoS Biology. May, 2015 | Pubmed ID: 25978860 Molecular Controls of Arterial Morphogenesis Circulation Research. May, 2015 | Pubmed ID: 25953926 Angiogenesis Versus Arteriogenesis: Neuropilin 1 Modulation of VEGF Signaling F1000prime Reports. 2015 | Pubmed ID: 25926977 Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis Arteriosclerosis, Thrombosis, and Vascular Biology. Jun, 2015 | Pubmed ID: 25882068 Endothelial Cell Metabolism in Normal and Diseased Vasculature Circulation Research. Mar, 2015 | Pubmed ID: 25814684 Molecular Controls of Lymphatic VEGFR3 Signaling Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2015 | Pubmed ID: 25524775 Up-regulation of Thrombospondin-2 in Akt1-null Mice Contributes to Compromised Tissue Repair Due to Abnormalities in Fibroblast Function The Journal of Biological Chemistry. Jan, 2015 | Pubmed ID: 25389299 ELAVL1 Regulates Alternative Splicing of EIF4E Transporter to Promote Postnatal Angiogenesis Proceedings of the National Academy of Sciences of the United States of America. Dec, 2014 | Pubmed ID: 25422430 Fox(y) Regulators of VEGF Receptors Circulation Research. Sep, 2014 | Pubmed ID: 25258399 Fibroblast Growth Factor Receptor 1 is a Key Inhibitor of TGFβ Signaling in the Endothelium Science Signaling. Sep, 2014 | Pubmed ID: 25249657 Chemokine-coupled β2 Integrin-induced Macrophage Rac2-Myosin IIA Interaction Regulates VEGF-A MRNA Stability and Arteriogenesis The Journal of Experimental Medicine. Sep, 2014 | Pubmed ID: 25180062 Endothelial Akt1 Mediates Angiogenesis by Phosphorylating Multiple Angiogenic Substrates Proceedings of the National Academy of Sciences of the United States of America. Sep, 2014 | Pubmed ID: 25136137 Lymphatic Fate Specification: an ERK-controlled Transcriptional Program Microvascular Research. Nov, 2014 | Pubmed ID: 25132472 Flow-regulated Lymphatic Vasculature Development and Signaling Vascular Cell. 2014 | Pubmed ID: 25053993 PTP1b is a Physiologic Regulator of Vascular Endothelial Growth Factor Signaling in Endothelial Cells Circulation. Sep, 2014 | Pubmed ID: 24982127 Netrin-1 Controls Sympathetic Arterial Innervation The Journal of Clinical Investigation. Jul, 2014 | Pubmed ID: 24937433 Vasa Vasorum in Normal and Diseased Arteries Circulation. Jun, 2014 | Pubmed ID: 24934463 Receptor Tyrosine Kinases Endocytosis in Endothelium: Biology and Signaling Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2014 | Pubmed ID: 24925972 The Docking Protein FRS2α is a Critical Regulator of VEGF Receptors Signaling Proceedings of the National Academy of Sciences of the United States of America. Apr, 2014 | Pubmed ID: 24706887 Angiocrine Factors Deployed by Tumor Vascular Niche Induce B Cell Lymphoma Invasiveness and Chemoresistance Cancer Cell. Mar, 2014 | Pubmed ID: 24651014 Inter-cellular Exchange of Cellular Components Via VE-cadherin-dependent Trans-endocytosis PloS One. 2014 | Pubmed ID: 24603875 Divergent Angiocrine Signals from Vascular Niche Balance Liver Regeneration and Fibrosis Nature. Jan, 2014 | Pubmed ID: 24256728 Angiopoietin-2 Secretion by Endothelial Cell Exosomes: Regulation by the Phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial Nitric Oxide Synthase (eNOS) and Syndecan-4/syntenin Pathways The Journal of Biological Chemistry. Jan, 2014 | Pubmed ID: 24235146 Transmembrane Protein ESDN Promotes Endothelial VEGF Signaling and Regulates Angiogenesis The Journal of Clinical Investigation. Dec, 2013 | Pubmed ID: 24177422 Endothelial Signaling and the Molecular Basis of Arteriovenous Malformation Cellular and Molecular Life Sciences : CMLS. Sep, 2013 | Pubmed ID: 24077895 Need Glucose to Sprout: Local Metabolic Control of Angiogenesis EMBO Molecular Medicine. 10, 2013 | Pubmed ID: 23982994 Physiology. Lymphatics Are in My Veins Science (New York, N.Y.). Aug, 2013 | Pubmed ID: 23929973 Endothelial Cell-dependent Regulation of Arteriogenesis Circulation Research. Oct, 2013 | Pubmed ID: 23897694 VEGFR2 Trafficking: Speed Doesn't Kill Cell Cycle (Georgetown, Tex.). Jul, 2013 | Pubmed ID: 23803732 Effects of Cell Grafting on Coronary Remodeling After Myocardial Infarction Journal of the American Heart Association. 2013 | Pubmed ID: 23723253 The Neuropilin 1 Cytoplasmic Domain is Required for VEGF-A-dependent Arteriogenesis Developmental Cell. Apr, 2013 | Pubmed ID: 23639442 Lymphatic Fate Determination: Playing RAF with ERK Cell Cycle (Georgetown, Tex.). Apr, 2013 | Pubmed ID: 23549166 Dll4-Notch Signaling Determines the Formation of Native Arterial Collateral Networks and Arterial Function in Mouse Ischemia Models Development (Cambridge, England). Apr, 2013 | Pubmed ID: 23533173 Endothelial RAF1/ERK Activation Regulates Arterial Morphogenesis Blood. May, 2013 | Pubmed ID: 23529931 The Syndecan-4/protein Kinase Cα Pathway Mediates Prostaglandin E2-induced Extracellular Regulated Kinase (ERK) Activation in Endothelial Cells and Angiogenesis in Vivo The Journal of Biological Chemistry. May, 2013 | Pubmed ID: 23525101 Endothelial ERK Signaling Controls Lymphatic Fate Specification The Journal of Clinical Investigation. Mar, 2013 | Pubmed ID: 23391722 Syndecan 4 Regulation of PDK1-dependent Akt Activation Cellular Signalling. Jan, 2013 | Pubmed ID: 22975683 FGF Regulates TGF-β Signaling and Endothelial-to-mesenchymal Transition Via Control of Let-7 MiRNA Expression Cell Reports. Dec, 2012 | Pubmed ID: 23200853 Endothelial Deletion of Murine Jag1 Leads to Valve Calcification and Congenital Heart Defects Associated with Alagille Syndrome Development (Cambridge, England). Dec, 2012 | Pubmed ID: 23095891 Endothelial Nuclear Factor-κB-dependent Regulation of Arteriogenesis and Branching Circulation. Nov, 2012 | Pubmed ID: 23091063 Profilin Phosphorylation As a VEGFR Effector in Angiogenesis Nature Cell Biology. Oct, 2012 | Pubmed ID: 23033049 Fibroblast Growth Factor-2 is Required for Vasa Vasorum Plexus Stability in Hypercholesterolemic Mice Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2012 | Pubmed ID: 22982464 "On-target" Cardiac Effects of Anticancer Drugs: Lessons from New Biology Journal of the American College of Cardiology. Aug, 2012 | Pubmed ID: 22703925 Fibroblast Growth Factor Signaling Potentiates VE-cadherin Stability at Adherens Junctions by Regulating SHP2 PloS One. 2012 | Pubmed ID: 22629427 Syndecan 4 Regulates FGFR1 Signaling in Endothelial Cells by Directing Macropinocytosis Science Signaling. May, 2012 | Pubmed ID: 22569333 ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway Developmental Cell. Mar, 2012 | Pubmed ID: 22421041 VEGF Signaling Inside Vascular Endothelial Cells and Beyond Current Opinion in Cell Biology. Apr, 2012 | Pubmed ID: 22366328 Endothelial-derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization Cell. Oct, 2011 | Pubmed ID: 22036563 Macrophage Skewing by Phd2 Haplodeficiency Prevents Ischaemia by Inducing Arteriogenesis Nature. Oct, 2011 | Pubmed ID: 21983962 개발과 SPECT/CT 하이브리드 이미징에 대 한 복합 대비 에이전트의 응용 프로그램 Bioconjugate Chemistry. Sep, 2011 | Pubmed ID: 21851119 FGF-dependent Regulation of VEGF Receptor 2 Expression in Mice The Journal of Clinical Investigation. Jul, 2011 | Pubmed ID: 21633168 Antiangiogenic Activity of RPAI-1(23) Promotes Vasa Vasorum Regression in Hypercholesterolemic Mice Through a Plasmin-dependent Mechanism Circulation Research. Jun, 2011 | Pubmed ID: 21546607 Phosphorylation of VE-cadherin Controls Endothelial Phenotypes Via P120-catenin Coupling and Rac1 Activation American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2011 | Pubmed ID: 21037229 Auxiliary and Autonomous Proteoglycan Signaling Networks Methods in Enzymology. 2010 | Pubmed ID: 20816202 Cell Communications in the Heart Circulation. Aug, 2010 | Pubmed ID: 20805439 Role of Synectin in Lymphatic Development in Zebrafish and Frogs Blood. Oct, 2010 | Pubmed ID: 20631376 VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis Developmental Cell. May, 2010 | Pubmed ID: 20434959 Micro Computed Tomography for Vascular Exploration Journal of Angiogenesis Research. Mar, 2010 | Pubmed ID: 20298533 ERK1/2-Akt1 Crosstalk Regulates Arteriogenesis in Mice and Zebrafish The Journal of Clinical Investigation. Apr, 2010 | Pubmed ID: 20237411 Suppression of RhoG Activity is Mediated by a Syndecan 4-synectin-RhoGDI1 Complex and is Reversed by PKCalpha in a Rac1 Activation Pathway The Journal of Cell Biology. Jul, 2009 | Pubmed ID: 19581409 Diabetic Monocyte and Vascular Endothelial Growth Factor Signaling Impairment Circulation. Jul, 2009 | Pubmed ID: 19564554 FRS2 Via Fibroblast Growth Factor Receptor 1 is Required for Platelet-derived Growth Factor Receptor Beta-mediated Regulation of Vascular Smooth Muscle Marker Gene Expression The Journal of Biological Chemistry. Jun, 2009 | Pubmed ID: 19339244 Regulation of Vascular Integrity Journal of Molecular Medicine (Berlin, Germany). Jun, 2009 | Pubmed ID: 19337719 VEGF and Restenosis: the Rest of the Story Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2009 | Pubmed ID: 19299328 Synectin-dependent Regulation of Arterial Maturation Developmental Dynamics : an Official Publication of the American Association of Anatomists. Mar, 2009 | Pubmed ID: 19235722 The Antiangiogenic Activity of RPAI-1(23) Inhibits Vasa Vasorum and Growth of Atherosclerotic Plaque Circulation Research. Feb, 2009 | Pubmed ID: 19122176 Syndecan-4 Mediates Macrophage Uptake of Group V Secretory Phospholipase A2-modified LDL Journal of Lipid Research. Apr, 2009 | Pubmed ID: 19056705 Endothelium As Master Regulator of Organ Development and Growth Vascular Pharmacology. Jan-Feb, 2009 | Pubmed ID: 18804188 Endothelium-driven Myocardial Growth or Nitric Oxide at the Crossroads Trends in Cardiovascular Medicine. Nov, 2008 | Pubmed ID: 19345317 Syndecan-4 Regulates Subcellular Localization of MTOR Complex2 and Akt Activation in a PKCalpha-dependent Manner in Endothelial Cells Molecular Cell. Oct, 2008 | Pubmed ID: 18851840 The FGF System Has a Key Role in Regulating Vascular Integrity The Journal of Clinical Investigation. Oct, 2008 | Pubmed ID: 18776942 저산소증 유도 마우스 폐동맥 고혈압 모델에서 다중 정맥 볼루스 투여 및 침습적 혈류역학 평가 Lingfeng Qin1, Bo Jiang2, Krisztina Zsebo3, Henricus J. Duckers3, Michael Simons4,5, Pei-Yu Chen4 1Department of Surgery, Yale University School of Medicine, 2Department of Vascular Surgery, The First Hospital of China Medical University, Key Laboratory of Pathogenesis, Prevention, and Therapeutics of Aortic Aneurysm, 3VasoRx Inc., 4Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, 5Department of Cell Biology, Yale University School of Medicine JoVE 63839 Medicina 동맥류 고지혈증 마우스 모델에서 오일 레드 O-염색된 전체 대동맥 병변의 이미징 및 분석 Pei-Yu Chen1, Lingfeng Qin2, Michael Simons1,3 1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, 2Department of Surgery, Yale University School of Medicine, 3Department of Cell Biology, Yale University School of Medicine JoVE 61277 Medicina
저산소증 유도 마우스 폐동맥 고혈압 모델에서 다중 정맥 볼루스 투여 및 침습적 혈류역학 평가 Lingfeng Qin1, Bo Jiang2, Krisztina Zsebo3, Henricus J. Duckers3, Michael Simons4,5, Pei-Yu Chen4 1Department of Surgery, Yale University School of Medicine, 2Department of Vascular Surgery, The First Hospital of China Medical University, Key Laboratory of Pathogenesis, Prevention, and Therapeutics of Aortic Aneurysm, 3VasoRx Inc., 4Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, 5Department of Cell Biology, Yale University School of Medicine JoVE 63839 Medicina
동맥류 고지혈증 마우스 모델에서 오일 레드 O-염색된 전체 대동맥 병변의 이미징 및 분석 Pei-Yu Chen1, Lingfeng Qin2, Michael Simons1,3 1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, 2Department of Surgery, Yale University School of Medicine, 3Department of Cell Biology, Yale University School of Medicine JoVE 61277 Medicina
