Nektarios Tavernarakis Institute of Molecular Biology and Biotechnology Foundation for Research and Technology-Hellas, Greece Biography Publications Institution JoVE Articles Nektarios Tavernarakis has not added a biography. If you are Nektarios Tavernarakis and would like to personalize this page please email our Author Liaison for assistance. Publications Mitochondrial Biogenesis in Organismal Senescence and Neurodegeneration Mechanisms of Ageing and Development. Sep, 2020 | Pubmed ID: 32891602 Inflammation Brakes Mitochondrial Metabolism in Obesity Nature Immunology. Aug, 2020 | Pubmed ID: 32855554 Inhibition of Autophagy Curtails Visual Loss in a Model of Autosomal Dominant Optic Atrophy Nature Communications. Aug, 2020 | Pubmed ID: 32788597 Nucleophagy Mediators and Mechanisms Progress in Molecular Biology and Translational Science. 2020 | Pubmed ID: 32620238 Editorial: Mitophagy in Physiology and Pathology Mechanisms of Ageing and Development. Jun, 2020 | Pubmed ID: 32569605 Regulation and Roles of Autophagy in the Brain Advances in Experimental Medicine and Biology. 2020 | Pubmed ID: 32468455 Molecular Interventions Towards Multiple Sclerosis Treatment Brain Sciences. May, 2020 | Pubmed ID: 32429225 Mitochondrial Turnover and Homeostasis in Ageing and Neurodegeneration FEBS Letters. Apr, 2020 | Pubmed ID: 32350855 Crosstalk Between Endo/Exocytosis and Autophagy in Health and Disease Biotechnology Journal. Aug, 2020 | Pubmed ID: 32143239 Regulation and Roles of Mitophagy at Synapses Mechanisms of Ageing and Development. 04, 2020 | Pubmed ID: 32084458 ACBP is an Appetite Stimulator Across Phylogenetic Barriers Cell Stress. Jan, 2020 | Pubmed ID: 32043075 Caenorhabditis Elegans As a Model System for Human Diseases Current Opinion in Biotechnology. Jun, 2020 | Pubmed ID: 31951916 Acyl-CoA-binding Protein (ACBP): a Phylogenetically Conserved Appetite Stimulator Cell Death & Disease. 01, 2020 | Pubmed ID: 31907349 Sex-specific Regulation of Neuronal Functions in Caenorhabditis Elegans: the Sex-determining Protein TRA-1 Represses Goa-1/Gα Molecular Genetics and Genomics : MGG. Mar, 2020 | Pubmed ID: 31776761 SUMOylation in Neurodegenerative Diseases Gerontology. 2020 | Pubmed ID: 31505513 Synaptic Vesicle Fusion is Modulated Through Feedback Inhibition by Dopamine Auto-receptors Synapse (New York, N.Y.). 01, 2020 | Pubmed ID: 31494966 Mitophagy and Neuroprotection Trends in Molecular Medicine. Jan, 2020 | Pubmed ID: 31375365 Mitochondrial Maturation Drives Germline Stem Cell Differentiation in Caenorhabditis Elegans Cell Death and Differentiation. 02, 2020 | Pubmed ID: 31217501 3,4-Dimethoxychalcone Induces Autophagy Through Activation of the Transcription Factors TFE3 and TFEB EMBO Molecular Medicine. 11, 2019 | Pubmed ID: 31609086 Emerging Roles of Lipophagy in Health and Disease Frontiers in Cell and Developmental Biology. 2019 | Pubmed ID: 31552248 The Cytoskeleton As a Modulator of Aging and Neurodegeneration Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 31493230 Mitophagy Inhibits Amyloid-β and Tau Pathology and Reverses Cognitive Deficits in Models of Alzheimer's Disease Nature Neuroscience. 03, 2019 | Pubmed ID: 30742114 Nucleophagy: from Homeostasis to Disease Cell Death and Differentiation. 03, 2019 | Pubmed ID: 30647432 Mitophagy Dynamics in Caenorhabditis Elegans Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30610729 Maintenance of Proteostasis by P Body-Mediated Regulation of EIF4E Availability During Aging in Caenorhabditis Elegans Cell Reports. 10, 2018 | Pubmed ID: 30282029 Hypoxia and Selective Autophagy in Cancer Development and Therapy Frontiers in Cell and Developmental Biology. 2018 | Pubmed ID: 30250843 Mechanisms of Mitophagy in Cellular Homeostasis, Physiology and Pathology Nature Cell Biology. Sep, 2018 | Pubmed ID: 30154567 Small Heat Shock Proteins and Neurodegeneration: Recent Developments Biomolecular Concepts. Aug, 2018 | Pubmed ID: 30133417 Novel Insights Into the Anti-aging Role of Mitophagy International Review of Cell and Molecular Biology. 2018 | Pubmed ID: 30072091 The Role of Mitophagy in Innate Immunity Frontiers in Immunology. 2018 | Pubmed ID: 29951054 Multimodal Sensory Processing in Open Biology. 06, 2018 | Pubmed ID: 29925633 Autophagy in Age-Associated Neurodegeneration Cells. May, 2018 | Pubmed ID: 29734735 Regulation and Roles of Autophagy at Synapses Trends in Cell Biology. 08, 2018 | Pubmed ID: 29731196 Sex-specific Regulation of Aging in Caenorhabditis Elegans Aging Cell. 06, 2018 | Pubmed ID: 29493066 Aspirin Recapitulates Features of Caloric Restriction Cell Reports. 02, 2018 | Pubmed ID: 29490275 Mitochondrial Contributions to Neuronal Development and Function Biological Chemistry. 06, 2018 | Pubmed ID: 29476663 Molecular Mechanisms of Cell Death: Recommendations of the Nomenclature Committee on Cell Death 2018 Cell Death and Differentiation. Mar, 2018 | Pubmed ID: 29362479 Demonstrating Improved Multiple Transport-Mean-Free-Path Imaging Capabilities of Light Sheet Microscopy in the Quantification of Fluorescence Dynamics Biotechnology Journal. Jan, 2018 | Pubmed ID: 29168308 Caenorhabditis Elegans Microinjection Bio-protocol. Oct, 2017 | Pubmed ID: 29071286 TEMPORARY REMOVAL: The PMR1 Pump in Alpha-synuclein Toxicity and Neurodegeneration Neuroscience Letters. Aug, 2017 | Pubmed ID: 28780169 Differential Adiponectin Signalling Couples ER Stress with Lipid Metabolism to Modulate Ageing in C. Elegans Scientific Reports. Jul, 2017 | Pubmed ID: 28698593 Modulation of Autophagy by BDNF Underlies Synaptic Plasticity Cell Metabolism. Jul, 2017 | Pubmed ID: 28683289 Molecular Definitions of Autophagy and Related Processes The EMBO Journal. Jul, 2017 | Pubmed ID: 28596378 Mitophagy and Age-related Pathologies: Development of New Therapeutics by Targeting Mitochondrial Turnover Pharmacology & Therapeutics. Oct, 2017 | Pubmed ID: 28461251 In Vivo Mitophagy Monitoring in Caenorhabditis Elegans to Determine Mitochondrial Homeostasis Bio-protocol. Apr, 2017 | Pubmed ID: 28405595 Monitoring Mitophagy During Aging in Caenorhabditis Elegans Methods in Molecular Biology (Clifton, N.J.). Mar, 2017 | Pubmed ID: 28324491 Protein Synthesis Rate Assessment by Fluorescence Recovery After Photobleaching (FRAP) Bio-protocol. Mar, 2017 | Pubmed ID: 28286807 Assessing Mitochondrial Selective Autophagy in the Nematode Caenorhabditis Elegans Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28276029 P-body and Stress Granule Quantification in Caenorhabditis Elegans Bio-protocol. Jan, 2017 | Pubmed ID: 28239624 Monitoring Autophagic Responses in Caenorhabditis Elegans Methods in Enzymology. 2017 | Pubmed ID: 28237114 The Role of SUMOylation in Ageing and Senescent Decline Mechanisms of Ageing and Development. Mar, 2017 | Pubmed ID: 28088449 Small Heat Shock Proteins in Ageing and Age-related Diseases Cell Stress & Chaperones. Jul, 2017 | Pubmed ID: 28074336 Autophagy and the Endo/exosomal Pathways in Health and Disease Biotechnology Journal. Jan, 2017 | Pubmed ID: 27976834 Ectopic Fat Deposition Contributes to Age-associated Pathology in Caenorhabditis Elegans Journal of Lipid Research. Jan, 2017 | Pubmed ID: 27884963 Mitochondrial Biogenesis and Clearance: a Balancing Act The FEBS Journal. Jan, 2017 | Pubmed ID: 27462821 Measuring Oxygen Consumption Rate in Caenorhabditis Elegans Bio-protocol. Dec, 2016 | Pubmed ID: 28239622 Intracellular Assessment of ATP Levels in Caenorhabditis Elegans Bio-protocol. Dec, 2016 | Pubmed ID: 28194429 Stage Dependent Nutritional Regulation of Transgenerational Longevity Nutrition and Healthy Aging. Oct, 2016 | Pubmed ID: 28035341 Differential Protein Distribution Between the Nucleus and Mitochondria: Implications in Aging Frontiers in Genetics. 2016 | Pubmed ID: 27695477 Selective and Differential Interactions of BNN27, a Novel C17-spiroepoxy Steroid Derivative, with TrkA Receptors, Regulating Neuronal Survival and Differentiation Neuropharmacology. 12, 2016 | Pubmed ID: 27618740 Mitophagy: In Sickness and in Health Molecular & Cellular Oncology. Jan, 2016 | Pubmed ID: 27308569 18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis Elegans and Neuronal Cultures Antioxidants & Redox Signaling. Dec, 2016 | Pubmed ID: 26886723 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition) Autophagy. Jan, 2016 | Pubmed ID: 26799652 Caenorhabditis Elegans As a Model for Cancer Research Molecular & Cellular Oncology. Apr-Jun, 2015 | Pubmed ID: 27308424 Interfacing Mitochondrial Biogenesis and Elimination to Enhance Host Pathogen Defense and Longevity Worm. Jul-Sep, 2015 | Pubmed ID: 26430570 FAH Domain Containing Protein 1 (FAHD-1) is Required for Mitochondrial Function and Locomotion Activity in C. Elegans PloS One. 2015 | Pubmed ID: 26266933 Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension Upon Mitochondrial Stress in C. elegans Current Biology : CB. Jul, 2015 | Pubmed ID: 26144971 Coupling Mitogenesis and Mitophagy for Longevity Autophagy. 2015 | Pubmed ID: 26083448 A Customized Light Sheet Microscope to Measure Spatio-temporal Protein Dynamics in Small Model Organisms PloS One. 2015 | Pubmed ID: 26000610 Mitochondria, Autophagy and Age-associated Neurodegenerative Diseases: New Insights into a Complex Interplay Biochimica Et Biophysica Acta. Nov, 2015 | Pubmed ID: 25917894 Coordination of Mitophagy and Mitochondrial Biogenesis During Ageing in C. Elegans Nature. May, 2015 | Pubmed ID: 25896323 Stress Responses During Ageing: Molecular Pathways Regulating Protein Homeostasis Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25804759 Unsaturated Fatty Acids Induce Non-canonical Autophagy The EMBO Journal. Apr, 2015 | Pubmed ID: 25586377 Protein Synthesis As an Integral Quality Control Mechanism During Ageing Ageing Research Reviews. Sep, 2015 | Pubmed ID: 25555680 20S Proteasome Activation Promotes Life Span Extension and Resistance to Proteotoxicity in Caenorhabditis Elegans FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2015 | Pubmed ID: 25395451 Enhanced Proteasome Degradation Extends Caenorhabditis Elegans Lifespan and Alleviates Aggregation-related Pathologies Free Radical Biology & Medicine. Oct, 2014 | Pubmed ID: 26461298 Necrotic Cell Death in Caenorhabditis Elegans Methods in Enzymology. 2014 | Pubmed ID: 25065889 Longevity Pathways and Memory Aging Frontiers in Genetics. 2014 | Pubmed ID: 24926313 Mitochondrial Homeostasis: the Interplay Between Mitophagy and Mitochondrial Biogenesis Experimental Gerontology. Aug, 2014 | Pubmed ID: 24486129 Cellular and Molecular Longevity Pathways: the Old and the New Trends in Endocrinology and Metabolism: TEM. Apr, 2014 | Pubmed ID: 24388148 Endonuclease G Mediates α-synuclein Cytotoxicity During Parkinson's Disease The EMBO Journal. Nov, 2013 | Pubmed ID: 24129513 Crosstalk Between Apoptosis, Necrosis and Autophagy Biochimica Et Biophysica Acta. Dec, 2013 | Pubmed ID: 23770045 GPA-14, a Gα(i) Subunit Mediates Dopaminergic Behavioral Plasticity in C. Elegans Behavioral and Brain Functions : BBF. Apr, 2013 | Pubmed ID: 23607404 Metabolic Control by Target of Rapamycin and Autophagy During Ageing - a Mini-review Gerontology. 2013 | Pubmed ID: 23594965 Oxidative Stress and Mitochondrial Protein Quality Control in Aging Journal of Proteomics. Oct, 2013 | Pubmed ID: 23563202 The Contactin RIG-6 Mediates Neuronal and Non-neuronal Cell Migration in Caenorhabditis Elegans Developmental Biology. Jan, 2013 | Pubmed ID: 23123963 Autophagy and Ageing: Insights from Invertebrate Model Organisms Ageing Research Reviews. Jan, 2013 | Pubmed ID: 22634332 Mitophagy in Neurodegeneration and Aging Frontiers in Genetics. 2012 | Pubmed ID: 23267366 Calcium Homeostasis in Aging Neurons Frontiers in Genetics. 2012 | Pubmed ID: 23060904 Embryonic and Induced Pluripotent Stem Cell Differentiation As a Tool in Neurobiology Biotechnology Journal. Sep, 2012 | Pubmed ID: 22890755 Cellular Stress Response Pathways and Ageing: Intricate Molecular Relationships The EMBO Journal. May, 2011 | Pubmed ID: 21587205 Microscopic Optical Projection Tomography in Vivo PloS One. Apr, 2011 | Pubmed ID: 21559481 Cell Tracking in Live Caenorhabditis Elegans Embryos Via Third Harmonic Generation Imaging Microscopy Measurements Journal of Biomedical Optics. Apr, 2011 | Pubmed ID: 21529088 Spermidine and Resveratrol Induce Autophagy by Distinct Pathways Converging on the Acetylproteome The Journal of Cell Biology. Feb, 2011 | Pubmed ID: 21339330 Correction for Specimen Movement and Rotation Errors for In-vivo Optical Projection Tomography Biomedical Optics Express. Jul, 2010 | Pubmed ID: 21258448 Modeling Human Diseases in Caenorhabditis Elegans Biotechnology Journal. Dec, 2010 | Pubmed ID: 21154667 Roles for SUMO Modification During Senescence Advances in Experimental Medicine and Biology. 2010 | Pubmed ID: 20886763 Non-apoptotic Cell Death in Caenorhabditis Elegans Developmental Dynamics : an Official Publication of the American Association of Anatomists. May, 2010 | Pubmed ID: 20108319 SUMOylation and Cell Signalling Biotechnology Journal. Dec, 2009 | Pubmed ID: 19946876 The NemaGENETAG Initiative: Large Scale Transposon Insertion Gene-tagging in Caenorhabditis Elegans Genetica. Sep, 2009 | Pubmed ID: 19343510 Cell-specific Monitoring of Protein Synthesis in Vivo PloS One. 2009 | Pubmed ID: 19234598 Autophagy in Caenorhabditis Elegans Biochimica Et Biophysica Acta. Sep, 2009 | Pubmed ID: 19150634 A Synaptic DEG/ENaC Ion Channel Mediates Learning in C. Elegans by Facilitating Dopamine Signalling The EMBO Journal. Dec, 2008 | Pubmed ID: 19037257 The Effects of P53 on Whole Organism Longevity Are Mediated by Autophagy Autophagy. Oct, 2008 | Pubmed ID: 18728385 Ageing and the Regulation of Protein Synthesis: a Balancing Act? Trends in Cell Biology. May, 2008 | Pubmed ID: 18346894 Protein Synthesis and Aging: EIF4E and the Soma Vs. Germline Distinction Cell Cycle (Georgetown, Tex.). May, 2007 | Pubmed ID: 17495543 Functional and Physical Interaction Between Bcl-X(L) and a BH3-like Domain in Beclin-1 The EMBO Journal. May, 2007 | Pubmed ID: 17446862 Cardiomyocyte Necrosis: Alternative Mechanisms, Effective Interventions Biochimica Et Biophysica Acta. Apr, 2007 | Pubmed ID: 17320988 Imaging of Caenorhabditis Elegans Neurons by Second-harmonic Generation and Two-photon Excitation Fluorescence Journal of Biomedical Optics. Mar-Apr, 2005 | Pubmed ID: 15910089 Assessment of de novo Protein Synthesis Rates in Caenorhabditis elegans Margarita Elena Papandreou*1,2, Konstantinos Palikaras*1,2, Nektarios Tavernarakis1,2 1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Greece, 2Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion, 70013, Crete, Greece JoVE 61170 Biología Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans Konstantinos Palikaras1,2, Nektarios Tavernarakis1,2 1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Greece, 2Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion, 70013, Crete, Greece JoVE 61169 Biología In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice Evandro F. Fang1,6, Konstantinos Palikaras2, Nuo Sun3, Elayne M. Fivenson1, Ryan D. Spangler4, Jesse S. Kerr1, Stephanie A. Cordonnier1, Yujun Hou1, Eszter Dombi5, Henok Kassahun6, Nektarios Tavernarakis2,7, Joanna Poulton5, Hilde Nilsen6, Vilhelm A. Bohr1,8 1Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 2Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, 3Center for Molecular Medicine, National Heart Lung and Blood Institute, National Institutes of Health, 4Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, 5Nuffield Department of Obstetrics and Gynaecology, University of Oxford, 6Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 7Department of Basic Sciences, Faculty of Medicine, University of Crete, 8Danish Center for Healthy Aging, University of Copenhagen JoVE 56301 Medicina
Assessment of de novo Protein Synthesis Rates in Caenorhabditis elegans Margarita Elena Papandreou*1,2, Konstantinos Palikaras*1,2, Nektarios Tavernarakis1,2 1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Greece, 2Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion, 70013, Crete, Greece JoVE 61170 Biología
Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans Konstantinos Palikaras1,2, Nektarios Tavernarakis1,2 1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Greece, 2Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion, 70013, Crete, Greece JoVE 61169 Biología
In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice Evandro F. Fang1,6, Konstantinos Palikaras2, Nuo Sun3, Elayne M. Fivenson1, Ryan D. Spangler4, Jesse S. Kerr1, Stephanie A. Cordonnier1, Yujun Hou1, Eszter Dombi5, Henok Kassahun6, Nektarios Tavernarakis2,7, Joanna Poulton5, Hilde Nilsen6, Vilhelm A. Bohr1,8 1Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 2Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, 3Center for Molecular Medicine, National Heart Lung and Blood Institute, National Institutes of Health, 4Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, 5Nuffield Department of Obstetrics and Gynaecology, University of Oxford, 6Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 7Department of Basic Sciences, Faculty of Medicine, University of Crete, 8Danish Center for Healthy Aging, University of Copenhagen JoVE 56301 Medicina