Robert P. Mecham Department of Cell Biology & Physiology Washington University School of Medicine Biography Publications Institution JoVE Articles Robert P. Mecham has not added a biography. If you are Robert P. Mecham and would like to personalize this page please email our Author Liaison for assistance. Publications Loss of Angiotensin II Type 2 Receptor Improves Blood Pressure in Elastin Insufficiency Frontiers in Cardiovascular Medicine. 2021 | Pubmed ID: 34790711 Deletion of Type VIII Collagen Reduces Blood Pressure, Increases Carotid Artery Functional Distensibility and Promotes Elastin Deposition Matrix Biology Plus. Dec, 2021 | Pubmed ID: 34693248 Vascular Smooth Muscle Cell Subpopulations and Neointimal Formation in Mouse Models of Elastin Insufficiency Arteriosclerosis, Thrombosis, and Vascular Biology. 12, 2021 | Pubmed ID: 34587758 Tissue-specific Smooth Muscle Cell Subtypes Identified by Transcriptional Profiling The International Journal of Biochemistry & Cell Biology. 10, 2021 | Pubmed ID: 34411694 JNK2 Gene Silencing for Elastic Matrix Regenerative Repair Tissue Engineering. Part A. Aug, 2021 | Pubmed ID: 34409851 Inhibition of NOX1 Mitigates Blood Pressure Increases in Elastin Insufficiency Function (Oxford, England). 2021 | Pubmed ID: 34223172 SVEP1 is a Human Coronary Artery Disease Locus That Promotes Atherosclerosis Science Translational Medicine. 03, 2021 | Pubmed ID: 33762433 Complex Consequences of Cantu Syndrome SUR2 Variant R1154Q in Genetically Modified Mice JCI Insight. 03, 2021 | Pubmed ID: 33529173 RNA Vaccines for COVID-19: 5 Things Every Cardiologist Should Know JACC. Basic to Translational Science. Dec, 2020 | Pubmed ID: 33251385 A Matricellular Protein Fibulin-4 is Essential for the Activation of Lysyl Oxidase Science Advances. Nov, 2020 | Pubmed ID: 33239290 Whole Exome Sequencing in Patients with Williams-Beuren Syndrome Followed by Disease Modeling in Mice Points to Four Novel Pathways That May Modify Stenosis Risk Human Molecular Genetics. May, 2020 | Pubmed ID: 32412588 Identification of the Growth Factor-binding Sequence in the Extracellular Matrix Protein MAGP-1 The Journal of Biological Chemistry. 02, 2020 | Pubmed ID: 31988245 Elastic Fiber Ultrastructure and Assembly Matrix Biology : Journal of the International Society for Matrix Biology. 11, 2019 | Pubmed ID: 31669522 Sodium-activated Potassium Channels Moderate Excitability in Vascular Smooth Muscle The Journal of Physiology. 10, 2019 | Pubmed ID: 31444905 Intracellular Retention of Mutant Lysyl Oxidase Leads to Aortic Dilation in Response to Increased Hemodynamic Stress JCI Insight. 06, 2019 | Pubmed ID: 31211696 Decreased Lysyl Oxidase Level Protects Against Development of Retinal Vascular Lesions in Diabetic Retinopathy Experimental Eye Research. 07, 2019 | Pubmed ID: 31022398 Cardiovascular Consequences of KATP Overactivity in Cantu Syndrome JCI Insight. 08, 2018 | Pubmed ID: 30089727 Extracellular Determinants of Arterial Morphogenesis, Growth, and Homeostasis Current Topics in Developmental Biology. 2018 | Pubmed ID: 29853177 Spatial and Temporal Changes in Extracellular Elastin and Laminin Distribution During Lung Alveolar Development Scientific Reports. 05, 2018 | Pubmed ID: 29844468 Requisite Endothelial Reactivation and Effective SiRNA Nanoparticle Targeting of Etv2/Er71 in Tumor Angiogenesis JCI Insight. 04, 2018 | Pubmed ID: 29669933 Microfibril-associated Glycoproteins MAGP-1 and MAGP-2 in Disease Matrix Biology : Journal of the International Society for Matrix Biology. 10, 2018 | Pubmed ID: 29524629 Contribution of Metabolic Disease to Bone Fragility in MAGP1-deficient Mice Matrix Biology : Journal of the International Society for Matrix Biology. 04, 2018 | Pubmed ID: 29519758 Elastin in Lung Development and Disease Pathogenesis Matrix Biology : Journal of the International Society for Matrix Biology. 11, 2018 | Pubmed ID: 29331337 Elastin Purification and Solubilization Methods in Cell Biology. 2018 | Pubmed ID: 29310779 Measurement of Elastin, Collagen, and Total Protein Levels in Tissues Methods in Cell Biology. 2018 | Pubmed ID: 29310774 FGF Receptors Control Alveolar Elastogenesis Development (Cambridge, England). 12, 2017 | Pubmed ID: 29122839 Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose-Induced Apoptosis Investigative Ophthalmology & Visual Science. 05, 2017 | Pubmed ID: 28538980 Fibulin-4 is Essential for Maintaining Arterial Wall Integrity in Conduit but Not Muscular Arteries Science Advances. May, 2017 | Pubmed ID: 28508064 Inhibition of MAPK-Erk Pathway In vivo Attenuates Aortic Valve Disease Processes in Emilin1-deficient Mouse Model Physiological Reports. Mar, 2017 | Pubmed ID: 28270590 Deficient Circumferential Growth Is the Primary Determinant of Aortic Obstruction Attributable to Partial Elastin Deficiency Arteriosclerosis, Thrombosis, and Vascular Biology. 05, 2017 | Pubmed ID: 28254817 Marrow Adipose Tissue Expansion Coincides with Insulin Resistance in MAGP1-Deficient Mice Frontiers in Endocrinology. 2016 | Pubmed ID: 27445989 Loss of Function Mutation in LOX Causes Thoracic Aortic Aneurysm and Dissection in Humans Proceedings of the National Academy of Sciences of the United States of America. 08, 2016 | Pubmed ID: 27432961 Albumin Contributes to Kidney Disease Progression in Alport Syndrome American Journal of Physiology. Renal Physiology. 07, 2016 | Pubmed ID: 27147675 Characterization of Metabolic Health in Mouse Models of Fibrillin-1 Perturbation Matrix Biology : Journal of the International Society for Matrix Biology. 09, 2016 | Pubmed ID: 26902431 Chronic Antihypertensive Treatment Improves Pulse Pressure but Not Large Artery Mechanics in a Mouse Model of Congenital Vascular Stiffness American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2015 | Pubmed ID: 26232234 Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with Both Elastic Fiber and Collagen Fibril Abnormalities The Journal of Biological Chemistry. Aug, 2015 | Pubmed ID: 26178373 The Microfibril-associated Glycoproteins (MAGPs) and the Microfibrillar Niche Matrix Biology : Journal of the International Society for Matrix Biology. Sep, 2015 | Pubmed ID: 25963142 Adamtsl2 Deletion Results in Bronchial Fibrillin Microfibril Accumulation and Bronchial Epithelial Dysplasia--a Novel Mouse Model Providing Insights into Geleophysic Dysplasia Disease Models & Mechanisms. May, 2015 | Pubmed ID: 25762570 Fibroblast Growth Factor 2 is Required for Epithelial Recovery, but Not for Pulmonary Fibrosis, in Response to Bleomycin American Journal of Respiratory Cell and Molecular Biology. Jan, 2015 | Pubmed ID: 24988442 The Extracellular Matrix Protein MAGP1 Supports Thermogenesis and Protects Against Obesity and Diabetes Through Regulation of TGF-β Diabetes. Jun, 2014 | Pubmed ID: 24458361 Altered Reactivity of Resistance Vasculature Contributes to Hypertension in Elastin Insufficiency American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2014 | Pubmed ID: 24414067 Nonselective Assembly of Fibrillin 1 and Fibrillin 2 in the Rodent Ocular Zonule and in Cultured Cells: Implications for Marfan Syndrome Investigative Ophthalmology & Visual Science. Dec, 2013 | Pubmed ID: 24265020 Ocular Phenotype of Fbn2-null Mice Investigative Ophthalmology & Visual Science. Nov, 2013 | Pubmed ID: 24130178 Hypotension Due to Kir6.1 Gain-of-function in Vascular Smooth Muscle Journal of the American Heart Association. Aug, 2013 | Pubmed ID: 23974906 Microfibril-associated Glycoprotein 2 (MAGP2) Loss of Function Has Pleiotropic Effects in Vivo The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 23963447 Zap70 Inhibits Syk-mediated Osteoclast Function Journal of Cellular Biochemistry. Aug, 2013 | Pubmed ID: 23494777 Development, Composition, and Structural Arrangements of the Ciliary Zonule of the Mouse Investigative Ophthalmology & Visual Science. Apr, 2013 | Pubmed ID: 23493297 A Fiber-based Constitutive Model Predicts Changes in Amount and Organization of Matrix Proteins with Development and Disease in the Mouse Aorta Biomechanics and Modeling in Mechanobiology. Jun, 2013 | Pubmed ID: 22790326 Overview of Extracellular Matrix Current Protocols in Cell Biology. Dec, 2012 | Pubmed ID: 23208544 Paxillin Contracts the Osteoclast Cytoskeleton Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Dec, 2012 | Pubmed ID: 22807029 Alternative Splicing and Tissue-specific Elastin Misassembly Act As Biological Modifiers of Human Elastin Gene Frameshift Mutations Associated with Dominant Cutis Laxa The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22573328 Oophorectomy-induced Bone Loss is Attenuated in MAGP1-deficient Mice Journal of Cellular Biochemistry. Jan, 2012 | Pubmed ID: 21898536 Inhibition of MicroRNA-29 Enhances Elastin Levels in Cells Haploinsufficient for Elastin and in Bioengineered Vessels Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2011 | Pubmed ID: 22095981 Genetic Modifiers of Cardiovascular Phenotype Caused by Elastin Haploinsufficiency Act by Extrinsic Noncomplementation The Journal of Biological Chemistry. Dec, 2011 | Pubmed ID: 22049077 Pathogenesis of Aortic Dilatation in Mucopolysaccharidosis VII Mice May Involve Complement Activation Molecular Genetics and Metabolism. Dec, 2011 | Pubmed ID: 21944884 Characterization of Erectile Function in Elastin Haploinsufficicent Mice The Journal of Sexual Medicine. Nov, 2011 | Pubmed ID: 21883953 Decreased Aortic Diameter and Compliance Precedes Blood Pressure Increases in Postnatal Development of Elastin-insufficient Mice American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2011 | Pubmed ID: 21536846 Oxidative Modifications of the C-terminal Domain of Tropoelastin Prevent Cell Binding The Journal of Biological Chemistry. Apr, 2011 | Pubmed ID: 21321118 New Insights into the Pathogenesis of Autosomal-dominant Cutis Laxa with Report of Five ELN Mutations Human Mutation. Apr, 2011 | Pubmed ID: 21309044 Evidence for Heterozygous Abnormalities of the Elastin Gene (ELN) Affecting the Quantity of Vocal Fold Elastic Fibers: a Pilot Study Journal of Voice : Official Journal of the Voice Foundation. Mar, 2011 | Pubmed ID: 20926252 Oxidative and Nitrosative Modifications of Tropoelastin Prevent Elastic Fiber Assembly in Vitro The Journal of Biological Chemistry. Nov, 2010 | Pubmed ID: 20847053 The Matrix-binding Domain of Microfibril-associated Glycoprotein-1 Targets Active Connective Tissue Growth Factor to a Fibroblast-produced Extracellular Matrix Macromolecular Bioscience. Nov, 2010 | Pubmed ID: 20799254 Mechanisms of Emphysema in Autosomal Dominant Cutis Laxa Matrix Biology : Journal of the International Society for Matrix Biology. Sep, 2010 | Pubmed ID: 20600892 Microfibril-associated Glycoprotein-1, an Extracellular Matrix Regulator of Bone Remodeling The Journal of Biological Chemistry. Jul, 2010 | Pubmed ID: 20501659 Discrete Contributions of Elastic Fiber Components to Arterial Development and Mechanical Compliance Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2009 | Pubmed ID: 19850904 Vascular Extracellular Matrix and Arterial Mechanics Physiological Reviews. Jul, 2009 | Pubmed ID: 19584318 Effects of Chronic Treatment with a Low Dose of Nicorandil on the Function of the Rat Aorta During Ageing Clinical and Experimental Pharmacology & Physiology. Oct, 2009 | Pubmed ID: 19473347 Reduced Vessel Elasticity Alters Cardiovascular Structure and Function in Newborn Mice Circulation Research. May, 2009 | Pubmed ID: 19372465 Fibrillins, Fibulins, and Matrix-associated Glycoprotein Modulate the Kinetics and Morphology of in Vitro Self-assembly of a Recombinant Elastin-like Polypeptide Biochemistry. Nov, 2008 | Pubmed ID: 18973305 Essential Role for Fibrillin-2 in Zebrafish Notochord and Vascular Morphogenesis Developmental Dynamics : an Official Publication of the American Association of Anatomists. Oct, 2008 | Pubmed ID: 18816837 Elastin Insufficiency Predisposes to Elevated Pulmonary Circulatory Pressures Through Changes in Elastic Artery Structure Journal of Applied Physiology (Bethesda, Md. : 1985). Nov, 2008 | Pubmed ID: 18772328 Deficiency in Microfibril-associated Glycoprotein-1 Leads to Complex Phenotypes in Multiple Organ Systems The Journal of Biological Chemistry. Sep, 2008 | Pubmed ID: 18625713 Modification and Functional Inactivation of the Tropoelastin Carboxy-terminal Domain in Cross-linked Elastin Matrix Biology : Journal of the International Society for Matrix Biology. Sep, 2008 | Pubmed ID: 18602002 Upregulation of Elastase Proteins Results in Aortic Dilatation in Mucopolysaccharidosis I Mice Molecular Genetics and Metabolism. Jul, 2008 | Pubmed ID: 18479957 Methods in Elastic Tissue Biology: Elastin Isolation and Purification Methods (San Diego, Calif.). May, 2008 | Pubmed ID: 18442703 Mice Lacking the Extracellular Matrix Protein MAGP1 Display Delayed Thrombotic Occlusion Following Vessel Injury Blood. Apr, 2008 | Pubmed ID: 18281502 Neutrophil Elastase Cleaves Laminin-332 (laminin-5) Generating Peptides That Are Chemotactic for Neutrophils The Journal of Biological Chemistry. Apr, 2008 | Pubmed ID: 18178964 Elastin Haploinsufficiency Induces Alternative Aging Processes in the Aorta Rejuvenation Research. Feb, 2008 | Pubmed ID: 18173368 Fibulin-2 is Dispensable for Mouse Development and Elastic Fiber Formation Molecular and Cellular Biology. Feb, 2008 | Pubmed ID: 18070922 New Insights into Elastic Fiber Assembly Birth Defects Research. Part C, Embryo Today : Reviews. Dec, 2007 | Pubmed ID: 18228265 The Intracellular Form of Human MAGP1 Elicits a Complex and Specific Transcriptional Response The International Journal of Biochemistry & Cell Biology. 2007 | Pubmed ID: 17692555 Functional Rescue of Elastin Insufficiency in Mice by the Human Elastin Gene: Implications for Mouse Models of Human Disease Circulation Research. Aug, 2007 | Pubmed ID: 17626896 Elastin-insufficient Mice Show Normal Cardiovascular Remodeling in 2K1C Hypertension Despite Higher Baseline Pressure and Unique Cardiovascular Architecture American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2007 | Pubmed ID: 17400710 Elastin Protein Levels Are a Vital Modifier Affecting Normal Lung Development and Susceptibility to Emphysema American Journal of Physiology. Lung Cellular and Molecular Physiology. Mar, 2007 | Pubmed ID: 17142349 Domains 16 and 17 of Tropoelastin in Elastic Fibre Formation The Biochemical Journal. Feb, 2007 | Pubmed ID: 17037986 Fibulin-5 Mutations: Mechanisms of Impaired Elastic Fiber Formation in Recessive Cutis Laxa Human Molecular Genetics. Dec, 2006 | Pubmed ID: 17035250 The Stumbling Block in Lung Repair of Emphysema: Elastic Fiber Assembly Proceedings of the American Thoracic Society. Jul, 2006 | Pubmed ID: 16799087 Specific Sequence Motifs Direct the Oxygenation and Chlorination of Tryptophan by Myeloperoxidase Biochemistry. Mar, 2006 | Pubmed ID: 16548523 Elastin Fragments Drive Disease Progression in a Murine Model of Emphysema The Journal of Clinical Investigation. Mar, 2006 | Pubmed ID: 16470245 Elastic Fiber Formation: a Dynamic View of Extracellular Matrix Assembly Using Timer Reporters Journal of Cellular Physiology. Apr, 2006 | Pubmed ID: 16261592 Tropoelastin Interacts with Cell-surface Glycosaminoglycans Via Its COOH-terminal Domain The Journal of Biological Chemistry. Dec, 2005 | Pubmed ID: 16192266 A Functional Mutation in the Terminal Exon of Elastin in Severe, Early-onset Chronic Obstructive Pulmonary Disease American Journal of Respiratory Cell and Molecular Biology. Oct, 2005 | Pubmed ID: 16081882 Effects of Elastin Haploinsufficiency on the Mechanical Behavior of Mouse Arteries American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2005 | Pubmed ID: 15863465 Altered Vascular Remodeling in Fibulin-5-deficient Mice Reveals a Role of Fibulin-5 in Smooth Muscle Cell Proliferation and Migration Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15710889 TGF-beta-dependent Pathogenesis of Mitral Valve Prolapse in a Mouse Model of Marfan Syndrome The Journal of Clinical Investigation. Dec, 2004 | Pubmed ID: 15546004 Vascular Extracellular Matrix and Aortic Development Current Topics in Developmental Biology. 2004 | Pubmed ID: 15522742 Deposition of Tropoelastin into the Extracellular Matrix Requires a Competent Elastic Fiber Scaffold but Not Live Cells Matrix Biology : Journal of the International Society for Matrix Biology. Apr, 2004 | Pubmed ID: 15172035 Neutrophil Serine Proteinases Inactivate Surfactant Protein D by Cleaving Within a Conserved Subregion of the Carbohydrate Recognition Domain The Journal of Biological Chemistry. Jun, 2004 | Pubmed ID: 15078883 Identification of a Major Microfibril-associated Glycoprotein-1-binding Domain in Fibrillin-2 The Journal of Biological Chemistry. May, 2004 | Pubmed ID: 15044481 Developmental Adaptation of the Mouse Cardiovascular System to Elastin Haploinsufficiency The Journal of Clinical Investigation. Nov, 2003 | Pubmed ID: 14597767 Dexamethasone Induction of Hypertension and Diabetes is PPAR-alpha Dependent in LDL Receptor-null Mice Nature Medicine. Aug, 2003 | Pubmed ID: 12847522 Fibrillin-1 and -2 Contain Heparin-binding Sites Important for Matrix Deposition and That Support Cell Attachment The Biochemical Journal. Oct, 2003 | Pubmed ID: 12837131 A Site on Laminin Alpha 5, AQARSAASKVKVSMKF, Induces Inflammatory Cell Production of Matrix Metalloproteinase-9 and Chemotaxis Journal of Immunology (Baltimore, Md. : 1950). Jul, 2003 | Pubmed ID: 12817023 Domains in Tropoelastin That Mediate Elastin Deposition in Vitro and in Vivo The Journal of Biological Chemistry. May, 2003 | Pubmed ID: 12626514 Hypertension and Prolonged Vasoconstrictor Signaling in RGS2-deficient Mice The Journal of Clinical Investigation. Feb, 2003 | Pubmed ID: 12588882 Lysyl Oxidase is Required for Vascular and Diaphragmatic Development in Mice The Journal of Biological Chemistry. Apr, 2003 | Pubmed ID: 12473682 The Microfibrillar Proteins MAGP-1 and Fibrillin-1 Form a Ternary Complex with the Chondroitin Sulfate Proteoglycan Decorin Molecular Biology of the Cell. May, 2000 | Pubmed ID: 10793130 Characterization of an in Vitro Model of Elastic Fiber Assembly Molecular Biology of the Cell. Nov, 1999 | Pubmed ID: 10564258 Identification of Tropoelastin As a Ligand for the 65-kD FK506-binding Protein, FKBP65, in the Secretory Pathway The Journal of Cell Biology. Jan, 1998 | Pubmed ID: 9442105 Chlamydomonas Agglutinin is a Hydroxyproline-rich Glycoprotein Proceedings of the National Academy of Sciences of the United States of America. Oct, 1983 | Pubmed ID: 16593377 Biologisk forberedelse og mekanisk teknikk for å bestemme viskoelastiske egenskaper til zonulære fibre Juan Rodriguez1,2, Matthew Reilly3, Robert P. Mecham4, Steven Bassnett2,4 1Department of Basic Sciences, University of Health Sciences and Pharmacy, 2Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, 3Department of Biomedical Engineering, The Ohio State University, 4Department of Cell Biology & Physiology, Washington University School of Medicine JoVE 63171 Medicina
Biologisk forberedelse og mekanisk teknikk for å bestemme viskoelastiske egenskaper til zonulære fibre Juan Rodriguez1,2, Matthew Reilly3, Robert P. Mecham4, Steven Bassnett2,4 1Department of Basic Sciences, University of Health Sciences and Pharmacy, 2Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, 3Department of Biomedical Engineering, The Ohio State University, 4Department of Cell Biology & Physiology, Washington University School of Medicine JoVE 63171 Medicina