Warren M. Zapol Department of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital and Harvard Medical School Biography Publications Institution JoVE Articles Warren M. Zapol has not added a biography. If you are Warren M. Zapol and would like to personalize this page please email our Author Liaison for assistance. Publications Hypoxia Ameliorates Brain Hyperoxia and NAD Deficiency in a Murine Model of Leigh Syndrome Molecular Genetics and Metabolism. 05, 2021 | Pubmed ID: 33752971 Airway Stem Cells Sense Hypoxia and Differentiate into Protective Solitary Neuroendocrine Cells Science (New York, N.Y.). 01, 2021 | Pubmed ID: 33384370 Antimicrobial Effects of Nitric Oxide in Murine Models of Klebsiella Pneumonia Redox Biology. 02, 2021 | Pubmed ID: 33352464 Rescue Treatment With High-Dose Gaseous Nitric Oxide in Spontaneously Breathing Patients With Severe Coronavirus Disease 2019 Critical Care Explorations. Nov, 2020 | Pubmed ID: 33225304 Ideation and Assessment of a Nitric Oxide Delivery System for Spontaneously Breathing Subjects Nitric Oxide : Biology and Chemistry. 11, 2020 | Pubmed ID: 32835810 Intratracheal Injection of Nitric Oxide, Generated from Air by Pulsed Electrical Discharge, for the Treatment of Pulmonary Hypertension in Awake Ambulatory Lambs Nitric Oxide : Biology and Chemistry. 04, 2020 | Pubmed ID: 31982629 Phototherapy and Extracorporeal Membrane Oxygenation Facilitate Removal of Carbon Monoxide in Rats Science Translational Medicine. 10, 2019 | Pubmed ID: 31597752 Leigh Syndrome Mouse Model Can Be Rescued by Interventions That Normalize Brain Hyperoxia, but Not HIF Activation Cell Metabolism. 10, 2019 | Pubmed ID: 31402314 Low Guanylyl Cyclase Activity in Weddell Seals: Implications for Peripheral Vasoconstriction and Perfusion of the Brain During Diving American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 06, 2019 | Pubmed ID: 30892912 Impaired Hypoxic Pulmonary Vasoconstriction in a Mouse Model of Leigh Syndrome American Journal of Physiology. Lung Cellular and Molecular Physiology. 02, 2019 | Pubmed ID: 30520688 Pharmacological Preconditioning with Inhaled Nitric Oxide (NO): Organ-specific Differences in the Lifetime of Blood and Tissue NO Metabolites Nitric Oxide : Biology and Chemistry. 11, 2018 | Pubmed ID: 30114529 Design, Synthesis, and Biological Evaluation of Allosteric Effectors That Enhance CO Release from Carboxyhemoglobin ACS Medicinal Chemistry Letters. Jul, 2018 | Pubmed ID: 30034606 A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells Molecular Pharmaceutics. 05, 2018 | Pubmed ID: 29634905 Targeting βCys93 in Hemoglobin S with an Antisickling Agent Possessing Dual Allosteric and Antioxidant Effects Metallomics : Integrated Biometal Science. 09, 2017 | Pubmed ID: 28770911 Sensitivity to Sevoflurane Anesthesia is Decreased in Mice with a Congenital Deletion of Guanylyl Cyclase-1 Alpha BMC Anesthesiology. 06, 2017 | Pubmed ID: 28615047 Hypoxia Treatment Reverses Neurodegenerative Disease in a Mouse Model of Leigh Syndrome Proceedings of the National Academy of Sciences of the United States of America. 05, 2017 | Pubmed ID: 28483998 Endothelial Dysfunction Inhibits the Ability of Haptoglobin to Prevent Hemoglobin-induced Hypertension American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2017 | Pubmed ID: 28314763 Pulmonary Phototherapy to Treat Carbon Monoxide Poisoning in Rats Shock (Augusta, Ga.). 06, 2017 | Pubmed ID: 27861257 Soluble Epoxide Hydrolase Deficiency or Inhibition Enhances Murine Hypoxic Pulmonary Vasoconstriction After Lipopolysaccharide Challenge American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2016 | Pubmed ID: 27815261 Detection and Removal of Impurities in Nitric Oxide Generated from Air by Pulsed Electrical Discharge Nitric Oxide : Biology and Chemistry. 11, 2016 | Pubmed ID: 27592386 Exposure of Stored Packed Erythrocytes to Nitric Oxide Prevents Transfusion-associated Pulmonary Hypertension Anesthesiology. 11, 2016 | Pubmed ID: 27517645 Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red Cells Circulation. 09, 2016 | Pubmed ID: 27515135 BMP Type I Receptor ALK2 is Required for Angiotensin II-induced Cardiac Hypertrophy American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2016 | Pubmed ID: 26873969 Pulmonary Phototherapy for Treating Carbon Monoxide Poisoning American Journal of Respiratory and Critical Care Medicine. Nov, 2015 | Pubmed ID: 26214119 Producing Nitric Oxide by Pulsed Electrical Discharge in Air for Portable Inhalation Therapy Science Translational Medicine. Jul, 2015 | Pubmed ID: 26136478 Pulmonary Hypertension After Prolonged Hypoxic Exposure in Mice with a Congenital Deficiency of Cyp2j American Journal of Respiratory Cell and Molecular Biology. May, 2015 | Pubmed ID: 25233285 Identification of a Small Molecule That Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling ACS Chemical Biology. Oct, 2014 | Pubmed ID: 25061917 Adverse Effects of Hemorrhagic Shock Resuscitation with Stored Blood Are Ameliorated by Inhaled Nitric Oxide in Lambs* Critical Care Medicine. Nov, 2013 | Pubmed ID: 23887236 Hemoglobin Infusion Does Not Alter Murine Pulmonary Vascular Tone Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Apr, 2013 | Pubmed ID: 23313572 Pulmonary Hypertension in Lambs Transfused with Stored Blood is Prevented by Breathing Nitric Oxide Anesthesiology. Mar, 2012 | Pubmed ID: 22293717 Inhibition of Bone Morphogenetic Protein Signaling Reduces Vascular Calcification and Atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2012 | Pubmed ID: 22223731 Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung Injury Anesthesiology. Nov, 2011 | Pubmed ID: 21912243 Administration of Hydrogen Sulfide Via Extracorporeal Membrane Lung Ventilation in Sheep with Partial Cardiopulmonary Bypass Perfusion: a Proof of Concept Study on Metabolic and Vasomotor Effects Critical Care (London, England). 2011 | Pubmed ID: 21299857 Soluble Guanylate Cyclase-α1 is Required for the Cardioprotective Effects of Inhaled Nitric Oxide American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2011 | Pubmed ID: 21257915 Nitric Oxide Synthase 3 Contributes to Ventilator-induced Lung Injury American Journal of Physiology. Lung Cellular and Molecular Physiology. Aug, 2010 | Pubmed ID: 20453164 Brief Periods of Nitric Oxide Inhalation Protect Against Myocardial Ischemia-reperfusion Injury Anesthesiology. Oct, 2008 | Pubmed ID: 18813047 In Vivo Characterization of Murine Myocardial Perfusion with Myocardial Contrast Echocardiography: Validation and Application in Nitric Oxide Synthase 3 Deficient Mice Circulation. Sep, 2007 | Pubmed ID: 17709634 Inhaled NO As a Therapeutic Agent Cardiovascular Research. Jul, 2007 | Pubmed ID: 17544387 A Selective Inducible NOS Dimerization Inhibitor Prevents Systemic, Cardiac, and Pulmonary Hemodynamic Dysfunction in Endotoxemic Mice American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2003 | Pubmed ID: 12907425 Um novo sistema de máscara de inalação para fornecer altas concentrações de gás óxido nítrico em sujeitos de respiração espontânea Riccardo Pinciroli1, Lisa Traeger1, Anna Fischbach1, Stefano Gianni1, Caio Cesar Araujo Morais1, Bijan Safaee Fakhr1, Raffaele Di Fenza1, Dianna Robinson3, Ryan Carroll2, Warren M. Zapol1, Lorenzo Berra1 1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 2Division of Pediatric Critical Care Medicine, Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, 3Respiratory Care, Massachusetts General Hospital JoVE 61769 Medicina
Um novo sistema de máscara de inalação para fornecer altas concentrações de gás óxido nítrico em sujeitos de respiração espontânea Riccardo Pinciroli1, Lisa Traeger1, Anna Fischbach1, Stefano Gianni1, Caio Cesar Araujo Morais1, Bijan Safaee Fakhr1, Raffaele Di Fenza1, Dianna Robinson3, Ryan Carroll2, Warren M. Zapol1, Lorenzo Berra1 1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 2Division of Pediatric Critical Care Medicine, Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, 3Respiratory Care, Massachusetts General Hospital JoVE 61769 Medicina