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Chapter 5

タンパク質の構造

Chapter 5

Protein Structure

Proteins are polymers of amino acids linked together by peptide bonds. Proteins and polypeptides are interchangeably used to refer to long chains of amino …
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular …
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to …
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein …
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally …
Many proteins can be classified into two distinct subtypes – globular or fibrous. These two types differ in their shapes and solubilities. Globular …
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows …
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes …
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with …
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or …
NEMO is a scaffolding protein which plays an essential role in the NF-κB pathway by assembling the IKK-complex with the kinases IKKα and …
Hydroxyl Radical Protein Footprinting (HRPF) is an emerging and promising higher order structural analysis technique that provides information on changes …
Protein aggregation is a hallmark of neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s …