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Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
 

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Article DOI: 10.3791/50418-v • 08:22 min • July 21st, 2013
July 21st, 2013 •
*1,2, *1,2,3, 1,2,3,4
1Department of Neurobiology & Behavior, University of California, Irvine, 2The Center for the Neurobiology of Learning and Memory, University of California, Irvine, 3The Center for Hearing Research, University of California, Irvine, 4Department of Biomedical Engineering, University of California, Irvine
* These authors contributed equally

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We describe a highly reproducible method for the permanent occlusion of a rodent major cerebral blood vessel. This technique can be accomplished with very little peripheral damage, minimal blood loss, a high rate of long-term survival, and consistent infarct volume commensurate with the human clinical population.

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Permanent Cerebral Vessel Occlusion Double Ligature Transection Stroke Ischemia Middle Cerebral Artery (MCA) Blood Flow Interruption Cortical Surface Blood Vessel Occlusion Ischemic Stroke Motor Capabilities Loss Sensory Deficits Animal Models Of Ischemia Permanent Middle Cerebral Artery Occlusion (pMCAO) Adult Rat Surgical Exposure Proximal Cortical Branch Occlusion Focal Ischemia Targeting
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