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Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
 

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Article DOI: 10.3791/52675-v • 09:48 min • May 4th, 2015
May 4th, 2015 •
1, 1, 1, 1, 1, 2, 1
1Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 2Department of Neurological Surgery, Washington University School of Medicine

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This protocol describes repetitive hypoxic preconditioning, or brief exposures to systemic hypoxia that reduce infarct volumes and blood-brain barrier disruption following transient middle cerebral artery occlusion in mice. It also details dual quantification of infarct volume and blood-brain barrier disruption after stroke to assess the efficacy of neurovascular protection.

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Quantification Neurovascular Protection Repetitive Hypoxic Preconditioning Transient Middle Cerebral Artery Occlusion Mice Experimental Animal Models Stroke Pathology Treatment Strategies RHP CNS Injury Focal Ischemic Stroke Infarct Volumes Blood-brain Barrier Disruption Post-stroke Inflammatory Response Endogenous CNS-protective Phenotype Dual Quantification Infarct Volume BBB Disruption Neurovascular Protection Swiss Webster Mice TMCAo (transient Middle Cerebral Artery Occlusion) Evans Blue (EB) Isoflurane Overdose
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