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Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector
 

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector

Article DOI: 10.3791/53670-v • 08:33 min • February 28th, 2016
February 28th, 2016 •
1, 2, 2, 3,4, 1,4, 1
1Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, 2Division of Nuclear Medicine, Leuven University Hospital - KU Leuven, 3Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 4Leuven Viral Vector Core, KU Leuven

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This manuscript describes how viral vector-mediated local gene delivery provides an attractive way to express transgenes in the central nervous system. The protocol outlines all crucial steps to perform a viral vector injection in the substantia nigra of the rat to develop a viral vector-based animal model for Parkinson's disease.

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Alpha-synuclein Rat Model Parkinson's Disease Stereotactic Injection Recombinant Adeno-associated Viral Vector Animal Model Pre-clinical Drug Testing Molecular Mechanism Neurodegenerative Disorders Brain Regions Vector System Gene Expression Bio-safety Issues Anesthesia Wistar Rat
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