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Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures
 

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures

Article DOI: 10.3791/56856-v • 10:01 min • March 12th, 2018
March 12th, 2018 •
1,2, 1, 3, 1, 1
1Department for Biomedical Research, University of Bern, 2Graduate School for Cellular and Biomedical Sciences, University of Bern, 3Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)

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Here we demonstrate a protocol to standardize sampling procedures of an established porcine model of acute myocardial infarction in order to increase its translational value in the understanding of the pathophysiology of myocardial ischemia/reperfusion injury and to test novel drug candidates.

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Porcine Closed Chest Myocardial Infarction Model Myocardial Ischemia Reperfusion Injury Cardiovascular Research Infarct Size Determination Precise Sampling Technique Anesthetics Carotid Arteries Venous Blood Sampling Blood Collection Tubes Citrated Plasma Collecting Tubes EDTA Plasma Collecting Tubes Serum Tube Pressure Catheter Fluoroscopic Guidance
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