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JoVE Journal Neuroscience
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
 

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Article DOI: 10.3791/61006-v • 08:55 min • April 24th, 2020
April 24th, 2020 •
1, 1, 2, 3
1North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 2Mechanical Engineer Consultant, 3Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin

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Automatic Translation

We describe and detail the use of the translaminar autonomous system. This system utilizes the human posterior segment to independently regulate the pressure inside the segment (intraocular) and surrounding the optic nerve (intracranial) to generate a translaminar pressure gradient that mimics features of glaucomatous optic neuropathy.

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Translaminar Autonomous System Model Intraocular Pressure Modulation Intracranial Pressure Modulation Human Posterior Segment Translaminar Pressure Gradient TAS Model Glaucoma Traumatic Brain Injury Idiopathic Intracranial Hypertension Spaceflight-associated Neuro-ocular Syndrome Inflow Syringes Perfusion Fluid Hydrophilic Filter Luer Stub Adapter ICP IOP Outflow Syringes Infusion Medium Whole Eye Globe Sample
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