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JoVE Journal Cancer Research
Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions
 

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions

Article DOI: 10.3791/62748-v • 07:39 min • November 17th, 2021
November 17th, 2021 •
1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 1, 1, 1,3, 1, 1,4
1Team Tumoral signaling and therapeutic targets, UMR CNRS 7021 - Laboratory of Bioimaging and Pathologies, 2NETRI, 3Centre de Ressources Biologiques, Pathology department, University Hospital of Strasbourg, 4Pediatric Oncohematology unit, University Hospital of Strasbourg

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Recent works uncover the neuronal impact on high-grade pediatric glioma (pHGG) cells and their reciprocal interactions. The present work shows the development of an in vitro model co-culturing pHGG cells and glutamatergic neurons and recorded their electrophysiological interactions to mimic those interactivities.

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Co-culture Glutamatergic Neurons Pediatric High-grade Glioma Cells Microfluidic Devices Electrical Interactions In Vitro Model Multielectrode Arrays Functional Studies Mechanistic Studies Pharmacological Agents Cell Migration Cell Interaction IPS-derived Cortical Glutamatergic Neurons Medium Replacement
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