Darren H. Freed Department of Surgery University of Alberta Biography Publications Institution JoVE Articles Darren H. Freed has not added a biography. If you are Darren H. Freed and would like to personalize this page please email our Author Liaison for assistance. Publications A Low-Cost Perfusate Alternative for Ex Vivo Lung Perfusion Transplantation Proceedings. Jul, 2020 | Pubmed ID: 32624230 Immunity and Stress Responses Are Induced During Ex Situ Heart Perfusion Circulation. Heart Failure. Jun, 2020 | Pubmed ID: 32498623 The Effects of Body Mass Index on Outcomes for Patients Undergoing Surgical Aortic Valve Replacement BMC Cardiovascular Disorders. May, 2020 | Pubmed ID: 32471345 Current Techniques and the Future of Lung Preservation Cryobiology. Jun, 2020 | Pubmed ID: 32361000 Addressing Organ Shortages: Progress in Donation After Circulatory Death for Liver Transplantation Canadian Journal of Surgery. Journal Canadien De Chirurgie. Mar, 2020 | Pubmed ID: 32195556 Maintaining the Permanence Principle for Death During in Situ Normothermic Regional Perfusion for Donation After Circulatory Death Organ Recovery: A United Kingdom and Canadian Proposal American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Jan, 2020 | Pubmed ID: 31922653 Valve-Sparing Aortic Root Replacement 3 Decades After Repair of Aortico-Left Ventricular Tunnel The Annals of Thoracic Surgery. 01, 2020 | Pubmed ID: 31228410 Cryopreservation Timing is a Critical Process Parameter in a Thymic Regulatory T-cell Therapy Manufacturing Protocol Cytotherapy. 12, 2019 | Pubmed ID: 31810768 End-Stage Liver Disease Models and Outcomes in Pediatric Patients Supported With Short-Term Continuous-Flow Ventricular Assist Devices ASAIO Journal (American Society for Artificial Internal Organs : 1992). Sep, 2019 | Pubmed ID: 31567409 Outcomes Following Bioprosthetic Valve Replacement in Prior Non-cardiac Transplant Recipients Clinical Transplantation. 11, 2019 | Pubmed ID: 31556148 Mimicking "J-Shaped" and Anisotropic Stress-Strain Behavior of Human and Porcine Aorta by Fabric-Reinforced Elastomer Composites ACS Applied Materials & Interfaces. Sep, 2019 | Pubmed ID: 31464413 Total Parenteral Nutrition in Ex Vivo Lung Perfusion: Addressing Metabolism Improves Both Inflammation and Oxygenation American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 12, 2019 | Pubmed ID: 31420938 Avoiding Initial Hypothermia Does Not Improve Liver Graft Quality in a Porcine Donation After Circulatory Death (DCD) Model of Normothermic Perfusion PloS One. 2019 | Pubmed ID: 31386697 Continuous Hemodialysis Does Not Improve Graft Function During Ex Vivo Lung Perfusion Over 24 Hours Transplantation Proceedings. Jul - Aug, 2019 | Pubmed ID: 31303418 Clearance of Transaminases During Normothermic Ex Situ Liver Perfusion PloS One. 2019 | Pubmed ID: 31017974 Heart Transplantation With Donation After Circulatory Death Circulation. Heart Failure. 04, 2019 | Pubmed ID: 30998395 Myocardial Functional Decline During Prolonged Ex Situ Heart Perfusion The Annals of Thoracic Surgery. 08, 2019 | Pubmed ID: 30872100 Enhanced Myocardial Protection in Cardiac Donation After Circulatory Death Using Intralipid Postconditioning in a Porcine Model Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie. 06, 2019 | Pubmed ID: 30790198 Preoperative Predictors of Mortality in Short-Term Continuous-Flow Ventricular Assist Devices ASAIO Journal (American Society for Artificial Internal Organs : 1992). Nov/Dec, 2019 | Pubmed ID: 30325847 Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts Journal of the American Heart Association. 10, 2018 | Pubmed ID: 30371322 Ex Vivo Perfusion Induces a Time- and Perfusate-dependent Molecular Repair Response in Explanted Porcine Lungs American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Sep, 2018 | Pubmed ID: 30230229 Normothermic Ex Vivo Machine Perfusion for Liver Grafts Recovered from Donors After Circulatory Death: A Systematic Review and Meta-Analysis HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery. 2018 | Pubmed ID: 29849531 Ex Situ Liver Perfusion: Organ Preservation into the Future Transplantation Reviews (Orlando, Fla.). 07, 2018 | Pubmed ID: 29691119 Advanced Dilated Cardiomyopathy in a Patient With Hutterite Limb-Girdle Muscular Dystrophy: Use of a Left Ventricular Assist Device Circulation. Heart Failure. 04, 2018 | Pubmed ID: 29626101 Transplantation of Hearts Donated After Circulatory Death Frontiers in Cardiovascular Medicine. 2018 | Pubmed ID: 29487855 Coronary Artery Bypass Surgery Improves Outcomes in Patients With Diabetes and Left Ventricular Dysfunction Journal of the American College of Cardiology. Feb, 2018 | Pubmed ID: 29471931 Steroids Limit Myocardial Edema During Ex Vivo Perfusion of Hearts Donated After Circulatory Death The Annals of Thoracic Surgery. Jun, 2018 | Pubmed ID: 29382512 Negative Pressure Ventilation Decreases Inflammation and Lung Edema During Normothermic Ex-vivo Lung Perfusion The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Apr, 2018 | Pubmed ID: 29103845 Driveline Site Is Not a Predictor of Infection After Ventricular Assist Device Implantation ASAIO Journal (American Society for Artificial Internal Organs : 1992). Sep/Oct, 2018 | Pubmed ID: 29035899 New Answers to Old Conundrums: What Antibodies, Exosomes and Inflammasomes Bring to the Conversation. Canadian National Transplant Research Program International Summit Report Transplantation. Feb, 2018 | Pubmed ID: 28731910 Corrigendum to "Preservation of Myocardial Perfusion and Function by Keeping Hypertrophied Heart Empty and Beating for Valve Surgery: An In Vivo MR Study of Pig Hearts" BioMed Research International. 2017 | Pubmed ID: 29457032 Inhibition of Pyruvate Dehydrogenase Kinase Improves Pulmonary Arterial Hypertension in Genetically Susceptible Patients Science Translational Medicine. Oct, 2017 | Pubmed ID: 29070699 Hypoxia Enhances the Therapeutic Potential of Superparamagnetic Iron Oxide-labeled Adipose-derived Stem Cells for Myocardial Infarction Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban. Aug, 2017 | Pubmed ID: 28786062 Extended Bridge to Heart and Lung Transplantation Using Pumpless Extracorporeal Lung Assist The Canadian Journal of Cardiology. 07, 2017 | Pubmed ID: 28579162 Preservation of Myocardial Perfusion and Function by Keeping Hypertrophied Heart Empty and Beating for Valve Surgery: An In Vivo MR Study of Pig Hearts BioMed Research International. 2017 | Pubmed ID: 28409155 A Leukocyte Filter Does Not Provide Further Benefit During Ex Vivo Lung Perfusion ASAIO Journal (American Society for Artificial Internal Organs : 1992). Sep/Oct, 2017 | Pubmed ID: 28234641 Impact of Reperfusion Calcium and PH on the Resuscitation of Hearts Donated After Circulatory Death The Annals of Thoracic Surgery. Jan, 2017 | Pubmed ID: 27526656 Basic and Clinical Observations of Mevalonate Depletion on the Mevalonate Signaling Pathway Current Molecular Pharmacology. 2017 | Pubmed ID: 26758946 Functional Assessment and Transplantation of the Donor Heart After Circulatory Death The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. 12, 2016 | Pubmed ID: 27916176 Externally Applied Static Magnetic Field Enhances Cardiac Retention and Functional Benefit of Magnetically Iron-Labeled Adipose-Derived Stem Cells in Infarcted Hearts Stem Cells Translational Medicine. 10, 2016 | Pubmed ID: 27400797 Inhibition of Viability, Proliferation, Cytokines Secretion, Surface Antigen Expression, and Adipogenic and Osteogenic Differentiation of Adipose-Derived Stem Cells by Seven-Day Exposure to 0.5 T Static Magnetic Fields Stem Cells International. 2016 | Pubmed ID: 26880984 Clinical and Angiographic Outcomes Associated with Surgical Revascularization of Angiographically Borderline 50-69% Coronary Artery Stenoses European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery. May, 2016 | Pubmed ID: 26825107 Donor Heart Preservation: Straight Up, or on the Rocks? Lancet (London, England). Jun, 2015 | Pubmed ID: 25888084 Successful Repair of Donation After Circulatory Death Lungs with Large Pulmonary Embolus Using the Lung Organ Care System for Ex Vivo Thrombolysis and Subsequent Clinical Transplantation Transplantation. Jan, 2015 | Pubmed ID: 25525922 A Whole Blood-based Perfusate Provides Superior Preservation of Myocardial Function During Ex Vivo Heart Perfusion The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Jan, 2015 | Pubmed ID: 25447577 Intermediate-term Outcomes of the Arterial Switch Operation for Transposition of Great Arteries in Neonates: Alive but Well? The Journal of Thoracic and Cardiovascular Surgery. Oct, 2006 | Pubmed ID: 17000296 A Novel Right Ventricular Volume and Pressure Loaded Piglet Heart Model for the Study of Tricuspid Valve Function. Lily Q. Lin1, Sanaz Hatami2, James Yashu Coe1, Timothy M. Colen1, Consolato Sergi3, Richard Thompson4, Elena S. Di Martino5, Walter Herzog6, Ziad Abu Sara6, Darren H. Freed2, Nee Scze Khoo1 1Division of Pediatric Cardiology, Department of Pediatrics, University of Alberta, 2Department of Surgery, University of Alberta, 3Department of Laboratory Medicine and Pathology, University of Alberta, 4Department of Biomedical Engineering, University of Alberta, 5Department of Civil Engineering, University of Calgary, 6Faculty of Kinesiology, University of Calgary JoVE 61251 Médecine
A Novel Right Ventricular Volume and Pressure Loaded Piglet Heart Model for the Study of Tricuspid Valve Function. Lily Q. Lin1, Sanaz Hatami2, James Yashu Coe1, Timothy M. Colen1, Consolato Sergi3, Richard Thompson4, Elena S. Di Martino5, Walter Herzog6, Ziad Abu Sara6, Darren H. Freed2, Nee Scze Khoo1 1Division of Pediatric Cardiology, Department of Pediatrics, University of Alberta, 2Department of Surgery, University of Alberta, 3Department of Laboratory Medicine and Pathology, University of Alberta, 4Department of Biomedical Engineering, University of Alberta, 5Department of Civil Engineering, University of Calgary, 6Faculty of Kinesiology, University of Calgary JoVE 61251 Médecine