Melinda K. Duncan Department of Biological Sciences University of Delaware Biography Publications Institution JoVE Articles Melinda K. Duncan has not added a biography. If you are Melinda K. Duncan and would like to personalize this page please email our Author Liaison for assistance. Publications ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment Cells. Nov, 2023 | Pubmed ID: 37998373 The Immediate Early Response of Lens Epithelial Cells to Lens Injury Cells. Nov, 2022 | Pubmed ID: 36359852 αVβ8 Integrin Targeting to Prevent Posterior Capsular Opacification JCI Insight. Nov, 2021 | Pubmed ID: 34554928 The Effect of Sex on the Mouse Lens Transcriptome Experimental Eye Research. Aug, 2021 | Pubmed ID: 34146586 The Aging Mouse Lens Transcriptome Experimental Eye Research. Aug, 2021 | Pubmed ID: 34119483 A Simple Method for Quantitating Confocal Fluorescent Images Biochemistry and Biophysics Reports. Mar, 2021 | Pubmed ID: 33553685 Morphometric Analysis of the Lens in Human Aniridia and Mouse Small Eye Experimental Eye Research. 02, 2021 | Pubmed ID: 33248069 Fibronectin Has Multifunctional Roles in Posterior Capsular Opacification (PCO) Matrix Biology : Journal of the International Society for Matrix Biology. Aug, 2020 | Pubmed ID: 32173580 A New Transgenic Reporter Line Reveals Wnt-dependent Snai2 Re-expression and Cranial Neural Crest Differentiation in Xenopus Scientific Reports. Aug, 2019 | Pubmed ID: 31371771 Cataract Surgeon Viewpoints on the Need for Novel Preventative Anti-inflammatory and Anti-posterior Capsular Opacification Therapies Current Medical Research and Opinion. Nov, 2019 | Pubmed ID: 31328581 Lens Epithelial Cells Initiate an Inflammatory Response Following Cataract Surgery Investigative Ophthalmology & Visual Science. Oct, 2018 | Pubmed ID: 30326070 Spatiotemporal Dynamics of Canonical Wnt Signaling During Embryonic Eye Development and Posterior Capsular Opacification (PCO) Experimental Eye Research. Oct, 2018 | Pubmed ID: 29932883 β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis Investigative Ophthalmology & Visual Science. Aug, 2017 | Pubmed ID: 28763805 The Molecular Mechanisms Underlying Lens Fiber Elongation Experimental Eye Research. Mar, 2017 | Pubmed ID: 27015931 Intravitreal Methotrexate Infusion for Proliferative Vitreoretinopathy Clinical Ophthalmology (Auckland, N.Z.). 2016 | Pubmed ID: 27698550 β1-integrin Controls Cell Fate Specification in Early Lens Development Differentiation; Research in Biological Diversity. 2016 | Pubmed ID: 27596755 Prox1 and Fibroblast Growth Factor Receptors Form a Novel Regulatory Loop Controlling Lens Fiber Differentiation and Gene Expression Development (Cambridge, England). Jan, 2016 | Pubmed ID: 26657765 Unfolded-protein Response-associated Stabilization of P27(Cdkn1b) Interferes with Lens Fiber Cell Denucleation, Leading to Cataract FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2016 | Pubmed ID: 26590164 Development of Novel Filtering Criteria to Analyze RNA-sequencing Data Obtained from the Murine Ocular Lens During Embryogenesis Genomics Data. Dec, 2014 | Pubmed ID: 25478318 The Zeb Proteins δEF1 and Sip1 May Have Distinct Functions in Lens Cells Following Cataract Surgery Investigative Ophthalmology & Visual Science. Jul, 2014 | Pubmed ID: 25082886 Beta-1 Integrin is Important for the Structural Maintenance and Homeostasis of Differentiating Fiber Cells The International Journal of Biochemistry & Cell Biology. May, 2014 | Pubmed ID: 24607497 Lens Extrusion from Laminin Alpha 1 Mutant Zebrafish TheScientificWorldJournal. 2014 | Pubmed ID: 24526906 The Roles of αV Integrins in Lens EMT and Posterior Capsular Opacification Journal of Cellular and Molecular Medicine. Apr, 2014 | Pubmed ID: 24495224 Loss of Sip1 Leads to Migration Defects and Retention of Ectodermal Markers During Lens Development Mechanisms of Development. Oct, 2013 | Pubmed ID: 24161570 Junctional Adhesion Molecule-A Regulates Vascular Endothelial Growth Factor Receptor-2 Signaling-dependent Mouse Corneal Wound Healing PloS One. 2013 | Pubmed ID: 23667656 The Unfolded Protein Response is Activated in Connexin 50 Mutant Mouse Lenses Experimental Eye Research. Sep, 2012 | Pubmed ID: 22713599 AV Integrins and TGF-β-induced EMT: a Circle of Regulation Journal of Cellular and Molecular Medicine. Mar, 2012 | Pubmed ID: 21883891 Focus on Molecules: Smad Interacting Protein 1 (Sip1, ZEB2, ZFHX1B) Experimental Eye Research. Aug, 2012 | Pubmed ID: 20868684 Development. A New Focus on RNA in the Lens Science (New York, N.Y.). Mar, 2011 | Pubmed ID: 21436425 Expression of βA3/A1-crystallin in the Developing and Adult Rat Eye Journal of Molecular Histology. Feb, 2011 | Pubmed ID: 21203897 Unfolded Protein Response (UPR) is Activated During Normal Lens Development Gene Expression Patterns : GEP. 2011 | Pubmed ID: 21044701 Characterizing Molecular Diffusion in the Lens Capsule Matrix Biology : Journal of the International Society for Matrix Biology. Apr, 2010 | Pubmed ID: 20026402 CD44 Expression is Developmentally Regulated in the Mouse Lens and Increases in the Lens Epithelium After Injury Differentiation; Research in Biological Diversity. Feb, 2010 | Pubmed ID: 19853364 Abnormal Expression of Collagen IV in Lens Activates Unfolded Protein Response Resulting in Cataract The Journal of Biological Chemistry. Dec, 2009 | Pubmed ID: 19858219 The Lens Capsule Experimental Eye Research. Feb, 2009 | Pubmed ID: 18773892 PCNA Interacts with Prox1 and Represses Its Transcriptional Activity Molecular Vision. 2008 | Pubmed ID: 19023449 Contributions of Mouse Genetic Background and Age on Anterior Lens Capsule Thickness Anatomical Record (Hoboken, N.J. : 2007). Dec, 2008 | Pubmed ID: 18951502 Differential Expression of the HMGN Family of Chromatin Proteins During Ocular Development Gene Expression Patterns : GEP. Jul, 2008 | Pubmed ID: 18502697 Dual Roles for Prox1 in the Regulation of the Chicken BetaB1-crystallin Promoter Investigative Ophthalmology & Visual Science. Apr, 2008 | Pubmed ID: 18385074 Attenuation of Junctional Adhesion Molecule-A is a Contributing Factor for Breast Cancer Cell Invasion Cancer Research. Apr, 2008 | Pubmed ID: 18381425 Genetic and Epigenetic Mechanisms of Gene Regulation During Lens Development Progress in Retinal and Eye Research. Nov, 2007 | Pubmed ID: 17905638 Conditional Deletion of Beta1-integrin from the Developing Lens Leads to Loss of the Lens Epithelial Phenotype Developmental Biology. Jun, 2007 | Pubmed ID: 17493607 Subfertility in Mice Harboring a Mutation in BetaB2-crystallin Molecular Vision. Mar, 2007 | Pubmed ID: 17392687 Deletion of JAM-A Causes Morphological Defects in the Corneal Epithelium The International Journal of Biochemistry & Cell Biology. 2007 | Pubmed ID: 17118692 Inbred FVB/N Mice Are Mutant at the Cp49/Bfsp2 Locus and Lack Beaded Filament Proteins in the Lens Investigative Ophthalmology & Visual Science. Nov, 2006 | Pubmed ID: 17065509 Regulation of AlphaA-crystallin Via Pax6, C-Maf, CREB and a Broad Domain of Lens-specific Chromatin The EMBO Journal. May, 2006 | Pubmed ID: 16675956 Production of Monoclonal Antibodies Against Prox1 Hybridoma (2005). Feb, 2006 | Pubmed ID: 16475879 Expression of Tissue Plasminogen Activator During Eye Development Experimental Eye Research. Jul, 2005 | Pubmed ID: 15978259 JAM-A Expression During Embryonic Development Developmental Dynamics : an Official Publication of the American Association of Anatomists. Aug, 2005 | Pubmed ID: 15977176 Palm is Expressed in Both Developing and Adult Mouse Lens and Retina BMC Ophthalmology. Jun, 2005 | Pubmed ID: 15969763 Ectopic Pax6 Expression Disturbs Lens Fiber Cell Differentiation Investigative Ophthalmology & Visual Science. Oct, 2004 | Pubmed ID: 15452066 OptiRNAi, an RNAi Design Tool Computer Methods and Programs in Biomedicine. Jul, 2004 | Pubmed ID: 15158049 Chromosomal Proteins HMGN3a and HMGN3b Regulate the Expression of Glycine Transporter 1 Molecular and Cellular Biology. May, 2004 | Pubmed ID: 15082770 Developmental Expression of Pop1/Bves The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Mar, 2004 | Pubmed ID: 14966204 Mafs, Prox1, and Pax6 Can Regulate Chicken BetaB1-crystallin Gene Expression The Journal of Biological Chemistry. Mar, 2004 | Pubmed ID: 14707122 Protein Expression Patterns for Ubiquitous and Tissue Specific Calpains in the Developing Mouse Lens Experimental Eye Research. Apr, 2003 | Pubmed ID: 12634108 A Comparative CDNA Microarray Analysis Reveals a Spectrum of Genes Regulated by Pax6 in Mouse Lens Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Dec, 2002 | Pubmed ID: 12485166 Collagen IV in the Developing Lens Capsule Matrix Biology : Journal of the International Society for Matrix Biology. Aug, 2002 | Pubmed ID: 12225806 General Utility of the Chicken BetaB1-crystallin Promoter to Drive Protein Expression in Lens Fiber Cells of Transgenic Mice Transgenic Research. Aug, 2002 | Pubmed ID: 12212842 Prox1 is Differentially Localized During Lens Development Mechanisms of Development. Mar, 2002 | Pubmed ID: 11850194 Overexpression of PAX6(5a) in Lens Fiber Cells Results in Cataract and Upregulation of (alpha)5(beta)1 Integrin Expression Journal of Cell Science. Sep, 2000 | Pubmed ID: 10954416 Truncated Forms of Pax-6 Disrupt Lens Morphology in Transgenic Mice Investigative Ophthalmology & Visual Science. Feb, 2000 | Pubmed ID: 10670477 Dual Roles for Pax-6: a Transcriptional Repressor of Lens Fiber Cell-specific Beta-crystallin Genes Molecular and Cellular Biology. Sep, 1998 | Pubmed ID: 9710641 Unraveling Molecular Mechanisms in PCO and Fibrosis Following Cataract Surgery Leah M. O'Neill1, Yan Wang1, Melinda K. Duncan1 1Department of Biological Sciences, University of Delaware JoVE 66050 Biologie
Unraveling Molecular Mechanisms in PCO and Fibrosis Following Cataract Surgery Leah M. O'Neill1, Yan Wang1, Melinda K. Duncan1 1Department of Biological Sciences, University of Delaware JoVE 66050 Biologie