René Hen Division of Systems Neuroscience New York State Psychiatric Institute Biography Publications Institution JoVE Articles René Hen has not added a biography. If you are René Hen and would like to personalize this page please email our Author Liaison for assistance. Publications Protocol for In vivo Imaging and Analysis of Brainstem Neuronal Activity in the Dorsal Raphe Nucleus of Freely Behaving Mice STAR Protocols. Jan, 2023 | Pubmed ID: 36853724 Enduring Effects of Early-life Adversity on Reward Processes: A Systematic Review and Meta-analysis of Animal Studies Neuroscience and Biobehavioral Reviews. Nov, 2022 | Pubmed ID: 36116576 Integrative Multi-omics Landscape of Fluoxetine Action Across 27 Brain Regions Reveals Global Increase in Energy Metabolism and Region-specific Chromatin Remodelling Molecular Psychiatry. Nov, 2022 | Pubmed ID: 36056172 Contribution of the Opioid System to the Antidepressant Effects of Fluoxetine Biological Psychiatry. Dec, 2022 | Pubmed ID: 35977861 Delineating a Serotonin 1B Receptor Circuit for Appetite Suppression in Mice The Journal of Experimental Medicine. Aug, 2022 | Pubmed ID: 35796804 Single-cell Activity and Network Properties of Dorsal Raphe Nucleus Serotonin Neurons During Emotionally Salient Behaviors Neuron. Aug, 2022 | Pubmed ID: 35700737 Dysregulation of Adult Hippocampal Neuroplasticity in Major Depression: Pathogenesis and Therapeutic Implications Molecular Psychiatry. Jun, 2022 | Pubmed ID: 35354926 Parallel Processing of Sensory Cue and Spatial Information in the Dentate Gyrus Cell Reports. Jan, 2022 | Pubmed ID: 35045280 Mu Opioid Receptors on Hippocampal GABAergic Interneurons Are Critical for the Antidepressant Effects of Tianeptine Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jun, 2022 | Pubmed ID: 34593976 Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression Cells. Apr, 2021 | Pubmed ID: 33919292 Adult Neurogenesis and Antidepressant Treatment: The Surprise Finding by Ron Duman and the Field 20 Years Later Biological Psychiatry. Jul, 2021 | Pubmed ID: 33771348 Adult Neurogenesis Augmentation Attenuates Anhedonia and HPA Axis Dysregulation in a Mouse Model of Chronic Stress and Depression Psychoneuroendocrinology. Feb, 2021 | Pubmed ID: 33302237 Contextual Fear Memory Retrieval by Correlated Ensembles of Ventral CA1 Neurons Nature Communications. Jul, 2020 | Pubmed ID: 32661319 A Distributed Neural Code in the Dentate Gyrus and in CA1 Neuron. Aug, 2020 | Pubmed ID: 32521223 Rapid Anxiolytic Effects of RS67333, a Serotonin Type 4 Receptor Agonist, and Diazepam, a Benzodiazepine, Are Mediated by Projections From the Prefrontal Cortex to the Dorsal Raphe Nucleus Biological Psychiatry. Mar, 2020 | Pubmed ID: 31623825 Contributions of Adult Neurogenesis to Dentate Gyrus Network Activity and Computations Behavioural Brain Research. Nov, 2019 | Pubmed ID: 31377252 Adult-born Hippocampal Neurons Bidirectionally Modulate Entorhinal Inputs into the Dentate Gyrus Science (New York, N.Y.). May, 2019 | Pubmed ID: 31073064 Resilience Is Associated With Larger Dentate Gyrus, While Suicide Decedents With Major Depressive Disorder Have Fewer Granule Neurons Biological Psychiatry. May, 2019 | Pubmed ID: 30819514 Functional Interrogation of a Depression-Related Serotonergic Single Nucleotide Polymorphism, Rs6295, Using a Humanized Mouse Model ACS Chemical Neuroscience. Jul, 2019 | Pubmed ID: 30694044 Loss of Adult 5-HT1A Autoreceptors Results in a Paradoxical Anxiogenic Response to Antidepressant Treatment The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2019 | Pubmed ID: 30552180 Hippocampal Neurogenesis Confers Stress Resilience by Inhibiting the Ventral Dentate Gyrus Nature. Jul, 2018 | Pubmed ID: 29950730 Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects Against Chronic Stress-Induced Impairments in Dendritic Spines and Fear Responses Cell Reports. Jun, 2018 | Pubmed ID: 29898391 Optimization of Immunolabeling and Clearing Techniques for Indelibly Labeled Memory Traces Hippocampus. Jul, 2018 | Pubmed ID: 29663578 Loss of MeCP2 in Adult 5-HT Neurons Induces 5-HT1A Autoreceptors, with Opposite Sex-dependent Anxiety and Depression Phenotypes Scientific Reports. Apr, 2018 | Pubmed ID: 29636529 Efficient and Accurate Extraction of in Vivo Calcium Signals from Microendoscopic Video Data ELife. Feb, 2018 | Pubmed ID: 29469809 Anxiety Cells in a Hippocampal-Hypothalamic Circuit Neuron. Feb, 2018 | Pubmed ID: 29397273 Optogenetic Activation of Granule Cells in the Dorsal Dentate Gyrus Enhances Dopaminergic Neurotransmission in the Nucleus Accumbens Neuroscience Research. Sep, 2018 | Pubmed ID: 29246683 A Novel Method for Chronic Social Defeat Stress in Female Mice Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2018 | Pubmed ID: 29090682 Treatment Resistant Depression: A Multi-scale, Systems Biology Approach Neuroscience and Biobehavioral Reviews. Jan, 2018 | Pubmed ID: 28859997 Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2017 | Pubmed ID: 29101244 Increasing Adult Hippocampal Neurogenesis in Mice After Exposure to Unpredictable Chronic Mild Stress May Counteract Some of the Effects of Stress Neuropharmacology. Nov, 2017 | Pubmed ID: 28890366 Gambling Disorder: an Integrative Review of Animal and Human Studies Annals of the New York Academy of Sciences. Apr, 2017 | Pubmed ID: 28486792 Adult Hippocampal Neurogenesis and Cognitive Flexibility - Linking Memory and Mood Nature Reviews. Neuroscience. Jun, 2017 | Pubmed ID: 28469276 The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Sep, 2017 | Pubmed ID: 28303899 Serotonin Receptors in Depression: from A to B F1000Research. 2017 | Pubmed ID: 28232871 S 38093, a Histamine H Antagonist/inverse Agonist, Promotes Hippocampal Neurogenesis and Improves Context Discrimination Task in Aged Mice Scientific Reports. Feb, 2017 | Pubmed ID: 28218311 Genetic and Modeling Approaches Reveal Distinct Components of Impulsive Behavior Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2017 | Pubmed ID: 27976680 Retinal Neuroprotective Effects of Flibanserin, an FDA-Approved Dual Serotonin Receptor Agonist-Antagonist PloS One. 2016 | Pubmed ID: 27447833 A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Nov, 2016 | Pubmed ID: 27353308 Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding Neuron. Apr, 2016 | Pubmed ID: 26971949 Activation of Local Inhibitory Circuits in the Dentate Gyrus by Adult-born Neurons Hippocampus. Jun, 2016 | Pubmed ID: 26662922 Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies Molecular Neurobiology. Dec, 2016 | Pubmed ID: 26660328 Neuroanatomic Differences Associated With Stress Susceptibility and Resilience Biological Psychiatry. May, 2016 | Pubmed ID: 26422005 Ketamine As a Prophylactic Against Stress-Induced Depressive-like Behavior Biological Psychiatry. May, 2016 | Pubmed ID: 26037911 Serotonin 1A and Serotonin 4 Receptors: Essential Mediators of the Neurogenic and Behavioral Actions of Antidepressants The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. Feb, 2016 | Pubmed ID: 25488850 Regulation of Hippocampal Memory Traces by Neurogenesis Neurogenesis (Austin, Tex.). 2015 | Pubmed ID: 27604158 Genetic Pharmacotherapy As an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice Frontiers in Systems Neuroscience. 2015 | Pubmed ID: 26778975 5-HT1A Receptors on Mature Dentate Gyrus Granule Cells Are Critical for the Antidepressant Response Nature Neuroscience. Nov, 2015 | Pubmed ID: 26389840 Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice Neuron. Sep, 2015 | Pubmed ID: 26335644 Running Rescues a Fear-based Contextual Discrimination Deficit in Aged Mice Frontiers in Systems Neuroscience. 2015 | Pubmed ID: 26321926 Functional Differentiation of Adult-born Neurons Along the Septotemporal Axis of the Dentate Gyrus Cold Spring Harbor Perspectives in Biology. Aug, 2015 | Pubmed ID: 26238355 Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity Neuron. May, 2015 | Pubmed ID: 25892302 Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Sep, 2015 | Pubmed ID: 25833129 Hippocampal Subfields and Major Depressive Disorder Biological Psychiatry. Feb, 2015 | Pubmed ID: 25542516 Suppression of Adult Neurogenesis Increases the Acute Effects of Kainic Acid Experimental Neurology. Feb, 2015 | Pubmed ID: 25476494 The Current State of the Neurogenic Theory of Depression and Anxiety Current Opinion in Neurobiology. Feb, 2015 | Pubmed ID: 25240202 From Psychiatric Disorders to Animal Models: a Bidirectional and Dimensional Approach Biological Psychiatry. Jan, 2015 | Pubmed ID: 24650688 Serotonin/dopamine Interactions in a Hyperactive Mouse: Reduced Serotonin Receptor 1B Activity Reverses Effects of Dopamine Transporter Knockout PloS One. 2014 | Pubmed ID: 25514162 The Participation of Cortical Amygdala in Innate, Odour-driven Behaviour Nature. Nov, 2014 | Pubmed ID: 25383519 Hippocampal Memory Traces Are Differentially Modulated by Experience, Time, and Adult Neurogenesis Neuron. Jul, 2014 | Pubmed ID: 24991962 Benzodiazepines and the Potential Trophic Effect of Antidepressants on Dentate Gyrus Cells in Mood Disorders The International Journal of Neuropsychopharmacology. Dec, 2014 | Pubmed ID: 24969726 Dendritic Inhibition in the Hippocampus Supports Fear Learning Science (New York, N.Y.). Feb, 2014 | Pubmed ID: 24558155 Functional Dissociation of Adult-born Neurons Along the Dorsoventral Axis of the Dentate Gyrus Hippocampus. Jul, 2014 | Pubmed ID: 24550158 Impact of Social Status and Antidepressant Treatment on Neurogenesis in the Baboon Hippocampus Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jul, 2014 | Pubmed ID: 24518288 Rapid Anxiolytic Effects of a 5-HT₄ Receptor Agonist Are Mediated by a Neurogenesis-independent Mechanism Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2014 | Pubmed ID: 24287720 Developmental Effects of Serotonin 1A Autoreceptors on Anxiety and Social Behavior Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jan, 2014 | Pubmed ID: 23907404 Adult Neurogenesis in the Mammalian Hippocampus: Why the Dentate Gyrus? Learning & Memory (Cold Spring Harbor, N.Y.). Nov, 2013 | Pubmed ID: 24255101 (Radio)active Neurogenesis in the Human Hippocampus Cell. Jun, 2013 | Pubmed ID: 23746833 Repeated Cortico-striatal Stimulation Generates Persistent OCD-like Behavior Science (New York, N.Y.). Jun, 2013 | Pubmed ID: 23744948 Differential Control of Learning and Anxiety Along the Dorsoventral Axis of the Dentate Gyrus Neuron. Mar, 2013 | Pubmed ID: 23473324 The Young and the Restless: Regulation of Adult Neurogenesis by Wnt Signaling Cell Stem Cell. Feb, 2013 | Pubmed ID: 23395437 Genetic Approaches for Understanding the Role of Serotonin Receptors in Mood and Behavior Current Opinion in Neurobiology. Jun, 2013 | Pubmed ID: 23385115 Hippocampal Granule Neuron Number and Dentate Gyrus Volume in Antidepressant-treated and Untreated Major Depression Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. May, 2013 | Pubmed ID: 23303074 Neurogenesis and Generalization: a New Approach to Stratify and Treat Anxiety Disorders Nature Neuroscience. Dec, 2012 | Pubmed ID: 23187693 NR2B-dependent Plasticity of Adult-born Granule Cells is Necessary for Context Discrimination The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2012 | Pubmed ID: 22723709 Hippocampal Angiogenesis and Progenitor Cell Proliferation Are Increased with Antidepressant Use in Major Depression Biological Psychiatry. Oct, 2012 | Pubmed ID: 22652019 Adult-born Hippocampal Neurons Promote Cognitive Flexibility in Mice Hippocampus. Sep, 2012 | Pubmed ID: 22431384 4- to 6-week-old Adult-born Hippocampal Neurons Influence Novelty-evoked Exploration and Contextual Fear Conditioning Hippocampus. May, 2012 | Pubmed ID: 21739523 Effects of Adult-generated Granule Cells on Coordinated Network Activity in the Dentate Gyrus Hippocampus. Jan, 2012 | Pubmed ID: 20882540 Experience Dictates Stem Cell Fate in the Adult Hippocampus Neuron. Jun, 2011 | Pubmed ID: 21658584 Pattern Separation: a Common Function for New Neurons in Hippocampus and Olfactory Bulb Neuron. May, 2011 | Pubmed ID: 21609817 Necessity of Hippocampal Neurogenesis for the Therapeutic Action of Antidepressants in Adult Nonhuman Primates PloS One. Apr, 2011 | Pubmed ID: 21525974 Serotonin-1A Autoreceptors Are Necessary and Sufficient for the Normal Formation of Circuits Underlying Innate Anxiety The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2011 | Pubmed ID: 21508226 Increasing Adult Hippocampal Neurogenesis is Sufficient to Improve Pattern Separation Nature. Apr, 2011 | Pubmed ID: 21460835 Modeling Treatment-resistant Depression Neuropharmacology. Sep, 2011 | Pubmed ID: 21356220 Functional Connectome of the Striatal Medium Spiny Neuron The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2011 | Pubmed ID: 21273403 Dorsal Vs Ventral Hippocampal Neurogenesis: Implications for Cognition and Mood Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jan, 2011 | Pubmed ID: 21116266 Krüppel-like Factor 9 is Necessary for Late-phase Neuronal Maturation in the Developing Dentate Gyrus and During Adult Hippocampal Neurogenesis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2009 | Pubmed ID: 19657039 Antidepressants Increase Neural Progenitor Cells in the Human Hippocampus Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Oct, 2009 | Pubmed ID: 19606083 Glutaminase-deficient Mice Display Hippocampal Hypoactivity, Insensitivity to Pro-psychotic Drugs and Potentiated Latent Inhibition: Relevance to Schizophrenia Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Sep, 2009 | Pubmed ID: 19516252 Antidepressant-induced Neurogenesis in the Hippocampus of Adult Nonhuman Primates The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2007 | Pubmed ID: 17475797 Neurodevelopmental Origins of Depressive Disorders Current Opinion in Pharmacology. Feb, 2007 | Pubmed ID: 17188022 Cortical 5-HT2A Receptor Signaling Modulates Anxiety-like Behaviors in Mice Science (New York, N.Y.). Jul, 2006 | Pubmed ID: 16873667 Hippocampal Neurogenesis: Regulation by Stress and Antidepressants Biological Psychiatry. Jun, 2006 | Pubmed ID: 16797263 Genetic Approaches to the Study of Anxiety Annual Review of Neuroscience. 2004 | Pubmed ID: 15217331 The Serotonergic System and Anxiety Neuromolecular Medicine. 2004 | Pubmed ID: 15001810 Resistance of Alpha -synuclein Null Mice to the Parkinsonian Neurotoxin MPTP Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12376616 Serotonin Receptor 1A Knockout: an Animal Model of Anxiety-related Disorder Proceedings of the National Academy of Sciences of the United States of America. Nov, 1998 | Pubmed ID: 9826725 An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice Clay Lacefield1,2, Hongtao Cai1, Huong Ho1, Carla Dias1, Hannah Chung1, René Hen1,2, Gergely F. Turi1,2 1Division of Systems Neuroscience, New York State Psychiatric Institute, 2Department of Psychiatry, Columbia University JoVE 64863 Neurosciences
An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice Clay Lacefield1,2, Hongtao Cai1, Huong Ho1, Carla Dias1, Hannah Chung1, René Hen1,2, Gergely F. Turi1,2 1Division of Systems Neuroscience, New York State Psychiatric Institute, 2Department of Psychiatry, Columbia University JoVE 64863 Neurosciences