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Startle Assay for Toxicity Evaluation in Zebrafish Embryo

January 12th, 2024
1, 1,2, 1, 1, 1,3, 4, 5, 1, 1, 6, 1
1Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology - Campus Nord, 2DITABIS AG - Digital Biomedical Imaging Systems AG, 3Centre for Organismal Studies, Heidelberg University, 4School of Biosciences, University of Birmingham, 5Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology - Campus Nord, 6Department of Bioanalytical Ecotoxicology, Helmholtz-Centre for Environmental Research - UFZ

Summary
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Vi beskriver et screeningssystems arbejdsgang og dataanalyse til evaluering af kemisk sammensat toksicitet baseret på zebrafiskens embryo vibration startle response. Systemet registrerer zebrafiskembryoners bevægelser efter eksponering for en vibrationsstimulus og giver mulighed for en integreret evaluering af generel toksicitet/dødelighed og neuromuskulær toksicitet.

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